Maternal Multiple Micronutrient Supplementation and Children's Cognition in Indonesia

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What was the effect of maternal multiple micronutrient (MMN) supplementation on procedural memory in children?

Improved procedural memory equivalent to half a year of schooling

What was the effect of maternal anemia in the MMN group on general intellectual ability in children?

Increased general intellectual ability equivalent to half a year of schooling

In the multiple regression models, what was the impact of socioenvironmental determinants compared to biomedical determinants on the outcomes?

Socioenvironmental determinants had larger and more consistent impact

How many tests showed a positive coefficient of MMN versus IFA?

18 out of 21 tests

What was the mean difference in general intellectual ability between MMN and IFA groups?

$0.11 SD (0.01–0.20)$

What was the primary focus of the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT) in Indonesia?

Improving maternal nutrition during pregnancy

What is the timeframe for the critical period of brain and cognitive development mentioned in the text?

First 1000 days from conception

What was the percentage of children re-enrolled for the follow-up study at age 9-12 years?

70%

Why were 574 children oversampled for the follow-up study?

Their mothers were anaemic or malnourished at SUMMIT enrolment

What is the need for an improved understanding of long-term influences of factors mentioned in the text?

To prioritize public health investments for optimizing human development

What was the impact of maternal multiple micronutrient (MMN) supplementation on general intellectual ability in children?

It resulted in a mean score increase of 0.11 SD in general intellectual ability compared to IFA

What was the effect of maternal anemia in the MMN group on procedural memory in children?

It resulted in a higher score in procedural memory compared to the IFA group

In the multiple regression models, what was the impact of socioenvironmental determinants compared to biomedical determinants on academic achievement?

Socioenvironmental determinants had a larger and more consistent impact than biomedical determinants

What was the mean difference in fine motor dexterity between children of mothers given MMN and those given IFA?

The mean difference was not significant between the two groups

How many tests showed a positive coefficient of MMN versus IFA, and what does this indicate?

18 tests showed a positive coefficient of MMN versus IFA, indicating a significant difference between the two groups

Explore the follow-up of the SUMMIT randomised trial in Indonesia, examining the influences of maternal multiple micronutrient supplementation and other biomedical and socioenvironmental factors on children’s cognition at age 9–12 years. Understand the impact on brain and cognitive development during early childhood.

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