Podcast
Questions and Answers
Mastocytosis is caused by the clonal proliferation of erythrocytes.
Mastocytosis is caused by the clonal proliferation of erythrocytes.
False (B)
Only a quarter of patients with mastocytosis report experiencing bone pains.
Only a quarter of patients with mastocytosis report experiencing bone pains.
True (A)
Symptoms of mastocytosis can include flushing and sweating due to histamine release.
Symptoms of mastocytosis can include flushing and sweating due to histamine release.
True (A)
Hepatosplenomegaly is a symptom commonly associated with mastocytosis.
Hepatosplenomegaly is a symptom commonly associated with mastocytosis.
Mastocytosis primarily affects the skin with no impact on the skeleton.
Mastocytosis primarily affects the skin with no impact on the skeleton.
Flashcards
What is mastocytosis?
What is mastocytosis?
A disease caused by an overgrowth of mast cells, often leading to symptoms like skin flushing, sweating, diarrhea, and abdominal cramps.
Does mastocytosis always cause bone pain?
Does mastocytosis always cause bone pain?
Around 25% of patients report experiencing pain in their bones due to the disease.
How can mastocytosis affect the skeleton?
How can mastocytosis affect the skeleton?
In mastocytosis, bone involvement can present as localized growths in the spine or as a general increase in bone density.
What are some other possible signs of mastocytosis?
What are some other possible signs of mastocytosis?
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What is the main culprit behind the symptoms of mastocytosis?
What is the main culprit behind the symptoms of mastocytosis?
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Study Notes
Mastocytosis Overview
- Mastocytosis is a disease caused by the clonal proliferation of mast cells.
- Symptoms often include histamine-related effects like flushing, sweating, diarrhea, and abdominal pain.
- Bone pain is reported by about a quarter of patients.
- Skeletal involvement can be focal (typically in the spine) or widespread, with increased bone density.
- Other potential features are hepatosplenomegaly and lymph node enlargement (retroperitoneal, mesenteric, periportal).
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