Mastering Nitroprusside
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Questions and Answers

Which of the following is a characteristic of calcium channel blockers (CCBs) on cardiac muscle?

  • Increase peripheral vascular resistance
  • Decrease AV node conduction (correct)
  • Increase SA node automaticity
  • Increase cardiac contractility
  • Which type of calcium channel blockers (CCBs) may cause a baroreceptor-mediated tachycardia?

  • Neither dihydropyridines nor non-dihydropyridines
  • Both dihydropyridines and non-dihydropyridines
  • Non-dihydropyridines
  • Dihydropyridines (correct)
  • Which type of smooth muscle is more sensitive to calcium channel blockers (CCBs)?

  • GI smooth muscle
  • Bronchiolar smooth muscle
  • Uterine smooth muscle
  • Arterial smooth muscle (correct)
  • Which type of CCBs cause constipation and have many drug interactions?

    <p>Non-dihydropyridine CCBs</p> Signup and view all the answers

    Which drug can cause Systemic Lupus Erythematosus (SLE)?

    <p>Hydralazine</p> Signup and view all the answers

    Which drug promotes hair growth?

    <p>Minoxidil</p> Signup and view all the answers

    Which of the following is NOT a symptom of toxicity of Nitroprusside?

    <p>Hypotension</p> Signup and view all the answers

    Which of the following is the correct onset and duration of action for Nitroglycerin spray?

    <p>Onset 2 min, Duration 25 min</p> Signup and view all the answers

    Which enzyme is most important for the activation of Nitroglycerin?

    <p>Aldehyde dehydrogenase isoform 2 (ALDH2)</p> Signup and view all the answers

    Which of the following is a potential mechanism for the development of tolerance to Nitroglycerin?

    <p>Systemic compensation</p> Signup and view all the answers

    Which of the following is a characteristic of all oral calcium channel blockers (CCBs)?

    <p>They come in long-acting products</p> Signup and view all the answers

    Which of the following adverse effects is associated with non-dihydropyridine CCBs?

    <p>Gingival hyperplasia</p> Signup and view all the answers

    Which of the following drugs is a potent arteriolar vasodilator and often coadministered with beta-blockers to prevent reflex tachycardia?

    <p>Hydralazine</p> Signup and view all the answers

    Which of the following is a common adverse effect of minoxidil?

    <p>Peripheral edema</p> Signup and view all the answers

    Which of the following is a characteristic of dihydropyridine calcium channel blockers (CCBs)?

    <p>They cause a baroreceptor-mediated tachycardia</p> Signup and view all the answers

    Which type of smooth muscle is more sensitive to calcium channel blockers (CCBs)?

    <p>Arterial smooth muscle</p> Signup and view all the answers

    Which of the following is a characteristic of non-dihydropyridine calcium channel blockers (CCBs)?

    <p>They slow AV conduction</p> Signup and view all the answers

    Which of the following calcium channel blockers (CCBs) causes peripheral edema and gastroesophageal reflux disease (GERD)?

    <p>Nifedipine</p> Signup and view all the answers

    Which of the following drugs is associated with thiocyanate poisoning?

    <p>Nitroprusside</p> Signup and view all the answers

    Which of the following calcium channel blockers (CCBs) is commonly coadministered with beta-blockers to prevent reflex tachycardia?

    <p>Nifedipine</p> Signup and view all the answers

    Which of the following calcium channel blockers (CCBs) is available in both oral and IV formulations?

    <p>Nicardipine</p> Signup and view all the answers

    Which of the following adverse effects is associated with dihydropyridine CCBs?

    <p>Peripheral edema</p> Signup and view all the answers

    Which of the following drugs is a substrate and inhibitor of 3A4 enzyme?

    <p>Verapamil</p> Signup and view all the answers

    Which of the following drugs is a potent arteriolar vasodilator and may cause hypertrichosis?

    <p>Minoxidil</p> Signup and view all the answers

    Which of the following drugs is a non-selective vasodilator that dilates both arterial and venous vessels?

    <p>Nitroprusside</p> Signup and view all the answers

    Which of the following drugs does NOT develop tolerance unlike nitroglycerin?

    <p>Nitroprusside</p> Signup and view all the answers

    Which of the following drugs causes only a modest increase in heart rate with a net decrease in myocardial oxygen consumption?

    <p>Nitroprusside</p> Signup and view all the answers

    Which of the following enzymes is most important for the activation of nitroglycerin?

    <p>Aldehyde dehydrogenase isoform 2 (ALDH2)</p> Signup and view all the answers

    Which of the following drugs is commonly coadministered with beta-blockers to prevent reflex tachycardia?

    <p>Nifedipine</p> Signup and view all the answers

    Which type of calcium channel blockers (CCBs) cause constipation and have many drug interactions?

    <p>Non-dihydropyridine CCBs</p> Signup and view all the answers

    Which of the following drugs is a potent arteriolar vasodilator and may cause hypertrichosis?

    <p>Minoxidil</p> Signup and view all the answers

    Which of the following is a characteristic of dihydropyridine calcium channel blockers (CCBs)?

    <p>They have a greater effect on arterial smooth muscle than venous smooth muscle.</p> Signup and view all the answers

    Which of the following calcium channel blockers (CCBs) causes peripheral edema and gastroesophageal reflux disease (GERD)?

    <p>Nifedipine</p> Signup and view all the answers

    Which type of smooth muscle is more sensitive to calcium channel blockers (CCBs) than bronchiolar, GI, and uterine smooth muscle?

    <p>Arterial smooth muscle</p> Signup and view all the answers

    Which of the following drugs is a non-selective vasodilator that dilates both arterial and venous vessels?

    <p>Nitroprusside</p> Signup and view all the answers

    Which of the following drugs does NOT develop tolerance unlike nitroglycerin?

    <p>Nitroprusside</p> Signup and view all the answers

    Which enzyme is most important for the activation of Nitroglycerin?

    <p>Aldehyde dehydrogenase isoform 2 (ALDH2)</p> Signup and view all the answers

    Which of the following adverse effects is associated with non-dihydropyridine CCBs?

    <p>Peripheral edema</p> Signup and view all the answers

    Which of the following drugs directly acts on the vasculature by releasing nitric oxide (NO)?

    <p>Nitroprusside</p> Signup and view all the answers

    Which of the following calcium channel blockers (CCBs) is commonly coadministered with beta-blockers to prevent reflex tachycardia?

    <p>Verapamil</p> Signup and view all the answers

    Which of the following drugs is a potent arteriolar vasodilator and may cause hypertrichosis?

    <p>Minoxidil</p> Signup and view all the answers

    Which of the following adverse effects is associated with non-dihydropyridine calcium channel blockers (CCBs)?

    <p>Peripheral edema</p> Signup and view all the answers

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