Mastering Heart Failure Treatment Strategies
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Questions and Answers

Which of the following is a strategy for the treatment of chronic heart failure?

  • Preventing acute exacerbations
  • Reducing exercise tolerance
  • Increasing blood volume
  • Inhibiting the Renin-Angiotensin-Aldosterone System (correct)
  • Which of the following is NOT a main drug used in chronic heart failure (HFrEF)?

  • Beta blockers (correct)
  • ACE inhibitors
  • Loop diuretics
  • Angiotensin II receptor blockers
  • What is the aim of treatment for heart failure?

  • Reduce exercise tolerance
  • Reduce mortality (correct)
  • Increase incidence of acute exacerbations
  • Increase symptoms
  • Which of the following is a lifestyle factor that can impact heart failure?

    <p>All of the above</p> Signup and view all the answers

    What is the mechanism of action of digoxin?

    <p>Increased myocardial contractility</p> Signup and view all the answers

    Which of the following is a non-pharmacological treatment for heart failure?

    <p>Pacing</p> Signup and view all the answers

    What is the main aim of using beta blockers in heart failure treatment?

    <p>Reduce symptoms</p> Signup and view all the answers

    Which of the following drugs inhibits the Renin-Angiotensin-Aldosterone System (RAAS)?

    <p>ACE inhibitors</p> Signup and view all the answers

    What is the term for heart failure with reduced ejection fraction?

    <p>Left Ventricular Systolic Dysfunction (LVSD)</p> Signup and view all the answers

    What are the main drugs used in the treatment of chronic heart failure?

    <p>ACE inhibitors and angiotensin II receptor blockers</p> Signup and view all the answers

    Which class of medications is recommended as step 1 treatment for chronic heart failure?

    <p>Diuretics</p> Signup and view all the answers

    Which class of medications is recommended as step 2 treatment for chronic heart failure?

    <p>Aldosterone receptor antagonists</p> Signup and view all the answers

    Which class of medications is recommended as step 3 treatment for chronic heart failure?

    <p>Beta-blockers</p> Signup and view all the answers

    Which class of medications is recommended as step 4 treatment for chronic heart failure?

    <p>ACE inhibitors</p> Signup and view all the answers

    Which class of medications is known to cause electrolyte disturbances, hypotension, and renal impairment as common side effects?

    <p>Diuretics</p> Signup and view all the answers

    Which class of medications is associated with a persistent dry cough and rare but serious angioedema as side effects?

    <p>ACE inhibitors</p> Signup and view all the answers

    Which class of medications is recommended for heart failure patients with reduced ejection fraction but stable NYHA class II-IV?

    <p>Beta-blockers</p> Signup and view all the answers

    Which class of medications can cause vasodilation through blockage of alpha-receptors and reduce renin release by the kidney?

    <p>Beta-blockers</p> Signup and view all the answers

    Which class of medications is less effective in African or Caribbean ethnicity and may require additional therapy with hydralazine and nitrate?

    <p>ACE inhibitors</p> Signup and view all the answers

    Which class of medications is recommended for heart failure patients with severe HF, current exacerbation of HF, heart block or bradycardia, persisting signs of fluid overload, or low blood pressure?

    <p>Beta-blockers</p> Signup and view all the answers

    Which of the following is a common cause of sudden ischaemia resulting in cardiac infarction?

    <p>Thrombosis</p> Signup and view all the answers

    What is the characteristic distribution of pain in angina pectoris?

    <p>Retrosternal, left side of chest, left arm, neck, jaw, and back</p> Signup and view all the answers

    Which of the following can cause angina pectoris?

    <p>Atherosclerosis</p> Signup and view all the answers

    What is the term for chest pain due to inadequate supply of oxygen to the heart?

    <p>Angina pectoris</p> Signup and view all the answers

    Which of the following can result in cell death and dysrhythmias due to cellular calcium overload?

    <p>Ischaemia</p> Signup and view all the answers

    What can shrink the window for coronary blood flow through the left ventricle?

    <p>All of the above</p> Signup and view all the answers

    Which class of medications is commonly used to prevent opening of voltage-gated L-type Ca2+ channels and mainly affects the heart and smooth muscle to inhibit calcium entry upon muscle cell depolarization?

    <p>Calcium channel blockers</p> Signup and view all the answers

    Which class of medications is used to reduce the metabolic demand of the muscle and can slow down the heart?

    <p>Beta-blockers</p> Signup and view all the answers

    Which class of medications is primarily responsible for dilating constricted coronary vessels, improving distribution of coronary blood flow towards ischemic areas, and is particularly beneficial in variant angina?

    <p>Organic nitrates</p> Signup and view all the answers

    Which class of medications is recommended as the first-line treatment for stable angina, but a calcium channel blocker (CCB) can be considered if control by beta-blockers is not optimal?

    <p>Beta-blockers</p> Signup and view all the answers

    Which class of medications is commonly used in the prevention and treatment of stable and unstable angina, and reduces cardiac oxygen consumption by slowing the heart?

    <p>Beta-blockers</p> Signup and view all the answers

    Which class of medications is known for their powerful vasodilator effects, works by being metabolized to nitric oxide (NO), and acts on veins to reduce cardiac preload?

    <p>Organic nitrates</p> Signup and view all the answers

    Which calcium channel blocker is contraindicated in patients with heart failure, bradycardia, AV block, or in the presence of a Beta-Blocker?

    <p>Verapamil</p> Signup and view all the answers

    Which calcium channel blocker is mainly used as an antidysrhythmic and can slow ventricular rate in rapid atrial fibrillation?

    <p>Verapamil</p> Signup and view all the answers

    Which potassium channel activator combines activation of potassium K+ATP channels with nitrovasodilator actions?

    <p>Nicorandil</p> Signup and view all the answers

    Which potassium channel activator is used for patients who remain symptomatic despite optimal management with other drugs, and can cause headaches, flushing, and dizziness?

    <p>Ranolazine</p> Signup and view all the answers

    Which drug inhibits funny “f”-type channels in the heart and reduces cardiac pacemaker activity?

    <p>Ivabradine</p> Signup and view all the answers

    Which drug is a unique anti-anginal used as a last resort?

    <p>Ranolazine</p> Signup and view all the answers

    Which calcium channel blocker is safe to use in patients with heart failure and can be used instead of a Beta-Blocker in Prinzmetal angina or alongside beta-blockers in most angina?

    <p>Amlodipine</p> Signup and view all the answers

    Which calcium channel blocker has a vasodilator effect mainly on resistance vessels, reduces afterload, and dilates coronary vessels (important in variant angina)?

    <p>Verapamil</p> Signup and view all the answers

    What are the indications for intravenous therapy?

    <p>Medicine is not available in another form</p> Signup and view all the answers

    What are the disadvantages of intravenous administration?

    <p>Requires volume of fluid to dilute the medicine</p> Signup and view all the answers

    What are the types of intravascular devices (IVDs)?

    <p>Peripheral venous catheters and central venous catheters</p> Signup and view all the answers

    What is the purpose of safe administration of intravenous drugs?

    <p>To prevent hazards and complications</p> Signup and view all the answers

    What are the reasons for using intravenous therapy?

    <p>To achieve a rapid onset of effect</p> Signup and view all the answers

    What is the main advantage of intravenous drug administration?

    <p>Rapid onset of action</p> Signup and view all the answers

    What are the risks associated with intravenous therapy?

    <p>High risk of infection</p> Signup and view all the answers

    What are the pharmacokinetic parameters that can affect the plasma concentration of IV drugs?

    <p>Distribution and elimination</p> Signup and view all the answers

    When should the oral route be used instead of intravenous administration?

    <p>When the medicine cannot be taken orally</p> Signup and view all the answers

    What is a potential advantage of intravenous therapy?

    <p>Constant or high blood level of medicine is needed</p> Signup and view all the answers

    What is the purpose of continuous infusion for intravenous medications?

    <p>To administer unstable drugs with long half-life</p> Signup and view all the answers

    What is the main advantage of intermittent infusion for intravenous medications?

    <p>To administer stable drugs with short half-life</p> Signup and view all the answers

    What are the hazards and complications associated with intravenous therapy?

    <p>All of the above</p> Signup and view all the answers

    What is the Visual Infusion Phlebitis Score (VIPS) used for?

    <p>To assess the severity of phlebitis during infusion</p> Signup and view all the answers

    How can the incidence of Red man syndrome be reduced during vancomycin infusion?

    <p>All of the above</p> Signup and view all the answers

    What is the bioavailability of a drug when administered through intravenous injection?

    <p>100%</p> Signup and view all the answers

    How does the plasma drug concentration change during intravenous infusion without drug elimination?

    <p>Remains constant over time</p> Signup and view all the answers

    What happens to the plasma drug concentration during intravenous infusion when drug elimination occurs?

    <p>Decreases linearly over time</p> Signup and view all the answers

    What is the term for the point at which the rate of drug input equals the rate of drug output during intravenous infusion?

    <p>Steady state</p> Signup and view all the answers

    What is clearance (CL) in the context of intravenous drug administration?

    <p>The volume of blood or plasma cleared of drug in a unit time</p> Signup and view all the answers

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