Podcast
Questions and Answers
Which drug inhibits dihydrofolate reductase, retarding DNA/RNA synthesis and protein synthesis?
Which drug inhibits dihydrofolate reductase, retarding DNA/RNA synthesis and protein synthesis?
Which drug is used as a topical treatment for actinic keratosis by blocking thymidykate synthase?
Which drug is used as a topical treatment for actinic keratosis by blocking thymidykate synthase?
Which drug binds tubulin and prevents mitotic spindle formation?
Which drug binds tubulin and prevents mitotic spindle formation?
Which drug induces microtubule stabilization, preventing anaphase?
Which drug induces microtubule stabilization, preventing anaphase?
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Which drug causes irreversible changes in DNA, RNA, and protein?
Which drug causes irreversible changes in DNA, RNA, and protein?
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Which drug forms intra-/interstrand crosslinks in DNA?
Which drug forms intra-/interstrand crosslinks in DNA?
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Which drug intercalates in DNA, leading to DNA breakage and inhibition of transcription?
Which drug intercalates in DNA, leading to DNA breakage and inhibition of transcription?
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Which drug inhibits topoisomerase I, leading to single-strand breaks in DNA and blocking DNA replication and transcription?
Which drug inhibits topoisomerase I, leading to single-strand breaks in DNA and blocking DNA replication and transcription?
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Which drug targets specific receptors like BCR ABL and HER2 for certain cancers like CML and breast cancer?
Which drug targets specific receptors like BCR ABL and HER2 for certain cancers like CML and breast cancer?
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Which drug is a nuclear hormone receptor targeted for hormone-related cancers like breast and prostate cancer?
Which drug is a nuclear hormone receptor targeted for hormone-related cancers like breast and prostate cancer?
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Which drug blocks thymidykate synthase after activation to 5-FDUMP and is used as a topical treatment for actinic keratosis?
Which drug blocks thymidykate synthase after activation to 5-FDUMP and is used as a topical treatment for actinic keratosis?
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Which drug inhibits dihydrofolate reductase, retarding DNA/RNA synthesis and protein synthesis?
Which drug inhibits dihydrofolate reductase, retarding DNA/RNA synthesis and protein synthesis?
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Study Notes
Cancer Drugs Overview
- Methotrexate is a folic acid analog that inhibits dihydrofolate reductase, retarding DNA/RNA synthesis and protein synthesis.
- 5-fluorouracil (5-Fu) blocks thymidykate synthase after activation to 5-FDUMP and is used as a topical treatment for actinic keratosis.
- Cytarabine (ara-C) is a cytosine analog that stalls DNA synthesis upon incorporation and inhibits DNA and RNA polymerase.
- Topoisomerase II inhibitors, such as Etoposide and Teniposide, lead to double-stranded DNA breaks and eventually apoptosis.
- Vinca alkaloids like Vinblastine and Vincristine bind tubulin and prevent mitotic spindle formation.
- Taxoids/Taxanes, like Paclitaxel, induce microtubule stabilization, preventing anaphase.
- Alkylating agents, like Cyclophosphamide, cause irreversible changes in DNA, RNA, and protein.
- Platinum compounds, like Cisplatin, form intra-/interstrand crosslinks in DNA.
- Antitumor antibiotics, such as Doxorubicin, intercalate in DNA, leading to DNA breakage and inhibition of transcription.
- Camptothecins, like Topotecan and Ironotecan, inhibit topoisomerase I, leading to single-strand breaks in DNA and blocking DNA replication and transcription.
- Nuclear hormone receptors, like Tamoxifen and Enzalutamide, are targeted for hormone-related cancers like breast and prostate cancer.
- Novel therapies, such as Tyrosine kinase inhibitors (e.g., Imatinib), target specific receptors like BCR ABL and HER2 for certain cancers like CML and breast cancer.
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Description
Test your knowledge of cancer drugs with this comprehensive overview of the mechanisms and uses of various chemotherapy agents. From methotrexate to novel therapies like tyrosine kinase inhibitors, this quiz covers the essential details of cancer drug action and application.
