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Questions and Answers
Which of the following antacids may cause constipation?
Which of the following antacids can cause hypercalcemia and milk-alkali syndrome?
Which of the following is not one of the four H2RAs approved in the US?
Which of the following is true about H2RAs?
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Which of the following is not a side effect of magnesium-containing antacids?
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Which of the following antacids has a short duration of action?
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Which of the following is not true about PPIs?
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Which of the following is a potential side effect of high doses of calcium carbonate in antacids?
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Which of the following antacids may cause osmotic diarrhea?
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Study Notes
- Antacids neutralize gastric acid and elevate intragastric pH, but have short duration of action.
- Magnesium-containing antacids may cause osmotic diarrhea and aluminum-containing antacids may cause constipation.
- High doses of calcium carbonate in antacids can cause hypercalcemia and milk-alkali syndrome.
- H2-receptor antagonists competitively inhibit histamine action, reducing gastric acid secretion.
- The four H2RAs approved in the US are cimetidine, ranitidine, famotidine, and nizatidine.
- H2RAs are safe with low frequency of severe adverse effects.
- PPIs irreversibly bind to the proton pump and are the most potent inhibitors of gastric acid secretion.
- PPIs inhibit both basal and stimulated gastric acid secretion in a sustained fashion.
- PPIs are prodrugs that require an acidic environment for conversion to the active sulfonamide.
- PPIs are absorbed in the small intestine and taken to the acidic secretory canaliculus of the parietal cell for protonation to the active form.
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Description
Test your knowledge on antacids, H2-receptor antagonists, and proton pump inhibitors with this informative quiz! Learn about the mechanisms of action, potential side effects, and safety profiles of these common medications used to treat acid-related disorders. Sharpen your understanding of hypercalcemia, milk-alkali syndrome, and the four H2RAs approved in the US. Challenge yourself to identify the prodrugs that require an acidic environment for conversion to the active sulfonamide and the medications
