10 Questions
Which of the following antacids may cause constipation?
Aluminum-containing antacids
Which of the following antacids can cause hypercalcemia and milk-alkali syndrome?
Calcium carbonate-containing antacids
Which of the following is not one of the four H2RAs approved in the US?
Omeprazole
Which of the following is true about H2RAs?
They inhibit both basal and stimulated gastric acid secretion in a sustained fashion.
Which of the following is not a side effect of magnesium-containing antacids?
Hypertension
Which of the following antacids has a short duration of action?
Sodium bicarbonate-containing antacids
Which of the following is not true about PPIs?
They are absorbed in the stomach and taken to the acidic secretory canaliculus of the parietal cell for protonation to the active form.
Which of the following is a potential side effect of high doses of calcium carbonate in antacids?
Hypercalcemia
Which of the following is not a H2RA approved in the US?
Omeprazole
Which of the following antacids may cause osmotic diarrhea?
Magnesium-containing antacids
Study Notes
- Antacids neutralize gastric acid and elevate intragastric pH, but have short duration of action.
- Magnesium-containing antacids may cause osmotic diarrhea and aluminum-containing antacids may cause constipation.
- High doses of calcium carbonate in antacids can cause hypercalcemia and milk-alkali syndrome.
- H2-receptor antagonists competitively inhibit histamine action, reducing gastric acid secretion.
- The four H2RAs approved in the US are cimetidine, ranitidine, famotidine, and nizatidine.
- H2RAs are safe with low frequency of severe adverse effects.
- PPIs irreversibly bind to the proton pump and are the most potent inhibitors of gastric acid secretion.
- PPIs inhibit both basal and stimulated gastric acid secretion in a sustained fashion.
- PPIs are prodrugs that require an acidic environment for conversion to the active sulfonamide.
- PPIs are absorbed in the small intestine and taken to the acidic secretory canaliculus of the parietal cell for protonation to the active form.
Test your knowledge on antacids, H2-receptor antagonists, and proton pump inhibitors with this informative quiz! Learn about the mechanisms of action, potential side effects, and safety profiles of these common medications used to treat acid-related disorders. Sharpen your understanding of hypercalcemia, milk-alkali syndrome, and the four H2RAs approved in the US. Challenge yourself to identify the prodrugs that require an acidic environment for conversion to the active sulfonamide and the medications
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