Podcast
Questions and Answers
Which enzyme catalyzes the first reaction in the TCA cycle?
Which enzyme catalyzes the first reaction in the TCA cycle?
- Citrate synthase (correct)
- Isocitrate dehydrogenase
- Succinate dehydrogenase
- Aconitase
What inhibits the activity of citrate synthase?
What inhibits the activity of citrate synthase?
- Citrate
- NADH
- Succinyl CoA
- All of the above (correct)
What is the rate limiting step in the formation of α-ketoglutarate from isocitrate?
What is the rate limiting step in the formation of α-ketoglutarate from isocitrate?
- Isocitrate dehydrogenase activity (correct)
- Aconitase activity
- Citrate synthase activity
- Fumarase activity
Which enzyme catalyzes the formation of succinyl CoA in the TCA cycle?
Which enzyme catalyzes the formation of succinyl CoA in the TCA cycle?
What is the final product of the TCA cycle?
What is the final product of the TCA cycle?
What activates the production of the first two NADH in the TCA cycle?
What activates the production of the first two NADH in the TCA cycle?
Which of the following is NOT a role of the TCA cycle in energy metabolism?
Which of the following is NOT a role of the TCA cycle in energy metabolism?
What is the key irreversible step in the conversion of pyruvate to acetyl-CoA?
What is the key irreversible step in the conversion of pyruvate to acetyl-CoA?
Which coenzymes are required for the activity of pyruvate dehydrogenase complex?
Which coenzymes are required for the activity of pyruvate dehydrogenase complex?
What is the mechanism of arsenic poisoning?
What is the mechanism of arsenic poisoning?
Which of the following is an allosteric effector of pyruvate dehydrogenase?
Which of the following is an allosteric effector of pyruvate dehydrogenase?
What is the major cause of congenital lactic acidemia?
What is the major cause of congenital lactic acidemia?
Which of the following is an anaplerotic reaction in the TCA cycle?
Which of the following is an anaplerotic reaction in the TCA cycle?
Which molecule is required for the activation of pyruvate carboxylase, the major anaplerotic enzyme?
Which molecule is required for the activation of pyruvate carboxylase, the major anaplerotic enzyme?
Which of the following can be formed from succinyl CoA in the liver and bone marrow?
Which of the following can be formed from succinyl CoA in the liver and bone marrow?
Which TCA cycle intermediate is converted to neurotransmitters GABA and glutamate in the brain?
Which TCA cycle intermediate is converted to neurotransmitters GABA and glutamate in the brain?
Which of the following is true about the efflux of intermediates of the TCA cycle?
Which of the following is true about the efflux of intermediates of the TCA cycle?
Which TCA cycle intermediate is used in gluconeogenesis during fasting?
Which TCA cycle intermediate is used in gluconeogenesis during fasting?
Which of the following can lead to lactic acidosis?
Which of the following can lead to lactic acidosis?
What happens when there is a depletion of oxaloacetate in the TCA cycle?
What happens when there is a depletion of oxaloacetate in the TCA cycle?
