Master the Replication Cycle of HIV
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Questions and Answers

Which protein undergoes a conformational change after binding to the CD4 molecule?

  • DC-SIGN
  • CXCR4
  • gp120 (correct)
  • CCR5

What is the function of the pre-integration complex?

  • Fusion with the host cell membrane
  • Facilitating reverse transcription (correct)
  • Formation of the pre-integration complex
  • Uncoating the capsid protein shell

Which molecule facilitates cell-to-cell spread of HIV?

  • CXCR4
  • CCR5
  • CD4
  • DC-SIGN (correct)

What is the role of the gp41 molecule during fusion with the host cell membrane?

<p>Coiling upon itself (D)</p> Signup and view all the answers

What are the two major co-receptors that the gp120 protein can bind to?

<p>CCR5 and CXCR4 (C)</p> Signup and view all the answers

Which gene in the HIV-1 genome encodes the proteins responsible for forming the core of the virion?

<p>GAG gene (A)</p> Signup and view all the answers

What is the main function of the POL gene in the HIV-1 genome?

<p>Processing viral proteins (A)</p> Signup and view all the answers

Which gene in the HIV-1 genome encodes the envelope glycoproteins?

<p>ENV gene (D)</p> Signup and view all the answers

Which regulatory genes are present in HIV-1?

<p>tat, rev, nef, vif, vpr, and vpu (C)</p> Signup and view all the answers

Which gene is lacking in HIV-2 compared to HIV-1?

<p>vpu gene (C)</p> Signup and view all the answers

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