Master the Basics of Selective Serotonin Reuptake Inhibitors (SSRIs) with this Q...

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Which of the following is the primary indication for antidepressant agents?

Treatment of schizophrenia

Treatment of anxiety disorders

Treatment of major depressive disorder (correct)

Treatment of bipolar disorder

According to the Centers for Disease Control and Prevention, what were the most commonly prescribed medications in the USA?

Antipsychotic drugs

Antidepressant drugs (correct)

Antibiotics

Antiepileptic drugs

What is the lifetime prevalence of major depression in the USA?

Around 5%

Around 25%

Around 10%

Around 17% (correct)

What is the point prevalence of major depression in the USA?

5% Signup and view all the answers

According to the learning objectives, which classes of antidepressant drugs are listed?

Tricyclic ADs, SSRIs, SNRIs, heterocyclic antidepressants, and MAO inhibitors Signup and view all the answers

What is the primary cellular target of antidepressant drugs?

Serotonin receptors Signup and view all the answers

Which of the following is a common side effect of tricyclic antidepressants (TCAs)?

Excessive sweating Signup and view all the answers

Which of the following is a characteristic of tertiary TCAs?

They have active metabolites Signup and view all the answers

Which of the following is a side effect of nefazodone?

Hepatotoxicity Signup and view all the answers

Which of the following is a characteristic of trazodone?

It can cause priapism Signup and view all the answers

Which of the following is an example of a heterocyclic tetracyclic antidepressant?

Mirtazapine Signup and view all the answers

Which of the following is a characteristic of amoxapine?

It is a metabolite of loxapine Signup and view all the answers

Which of the following is NOT a disorder for which antidepressants have received FDA approval?

Post-traumatic stress disorder Signup and view all the answers

Which hypothesis suggests that a deficit in function or amount of monoamines is central to the biology of depression?

Monoamine hypothesis Signup and view all the answers

Which mechanism is shared by almost all antidepressants?

Inhibition of the activity of serotonin transporter (SERT) Signup and view all the answers

Which class of antidepressant drugs inhibits the enzymatic degradation of monoamines?

MAO inhibitors (MAOIs) Signup and view all the answers

Which selective serotonin reuptake inhibitor (SSRI) has the longest half-life?

Fluoxetine Signup and view all the answers

Which antidepressant class has relatively long half-lives ranging from 18 to 70 hours?

Tricyclic Antidepressants (TCAs) Signup and view all the answers

Which of the following is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

Headache Signup and view all the answers

Which SSRI has a long half-life and a decreased incidence of discontinuation syndromes?

Fluoxetine Signup and view all the answers

Which of the following can be a disadvantage of fluoxetine due to its long half-life?

Induction of mania Signup and view all the answers

Which class of antidepressants inhibits both serotonin and noradrenergic reuptake?

Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs) Signup and view all the answers

Which SNRI has minimal drug interactions and almost no P450 activity?

Desvenlafaxine Signup and view all the answers

Which SNRI is indicated for major depressive disorder, diabetic peripheral neuropathic pain, and generalized anxiety disorder?

Duloxetine Signup and view all the answers

Which of the following is a characteristic of bupropion?

It lowers seizure threshold. Signup and view all the answers

What is the mechanism by which bupropion enhances the ability of patients to abstain from smoking?

Noradrenergic and/or dopaminergic mechanisms. Signup and view all the answers

Which of the following is a characteristic of mirtazapine?

It is a potent agonist of histamine (H1) receptors. Signup and view all the answers

What is a potential side effect of mirtazapine?

Increased sedation at higher doses. Signup and view all the answers

Which of the following is true about monoamine oxidase inhibitors (MAOIs)?

They cause a decrease in brain amine levels. Signup and view all the answers

What can happen if MAOIs are taken with tyramine-rich foods or sympathomimetics?

Orthostatic hypotension. Signup and view all the answers

Which of the following is NOT a major class of antidepressant drugs?

Heterocyclics antidepressants Signup and view all the answers

Which of the following is a primary cellular target of antidepressant drugs?

Transporters Signup and view all the answers

Which of the following is a common therapeutic indication for antidepressant drugs?

Anxiety disorders Signup and view all the answers

Which of the following is a common adverse effect of classical antidepressants?

Insomnia Signup and view all the answers

Which of the following is a potential interaction of St. John's wort with other antidepressant drugs?

Decreased efficacy Signup and view all the answers

What is the prevalence of major depression in the USA?

17% Signup and view all the answers

Which of the following is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

Insomnia Signup and view all the answers

Which SNRI has minimal drug interactions and almost no P450 activity?

Desvenlafaxine Signup and view all the answers

What is a potential side effect of mirtazapine?

Nausea Signup and view all the answers

Which SSRI has a long half-life and a decreased incidence of discontinuation syndromes?

Fluoxetine Signup and view all the answers

Which of the following is a characteristic of bupropion?

Minimal drug interactions Signup and view all the answers

Which of the following is a characteristic of trazodone?

Causes sexual side effects Signup and view all the answers

Which of the following is a side effect of tricyclic antidepressants (TCAs)?

Dry mouth Signup and view all the answers

Which of the following is a potential serious side effect of tricyclic antidepressants (TCAs)?

Orthostatic hypotension Signup and view all the answers

Which of the following antidepressants is associated with priapism as a serious side effect?

Trazodone Signup and view all the answers

Which of the following antidepressants is a weak inhibitor of both serotonin and norepinephrine reuptake?

Nefazodone Signup and view all the answers

Which of the following antidepressants is a metabolite of Loxapine and retains some antipsychotic activity?

Amoxapine Signup and view all the answers

Which of the following antidepressants is primarily used for unipolar depression, anxiety disorder, and insomnia?

Trazodone Signup and view all the answers

Which of the following is a characteristic of selective serotonin reuptake inhibitors (SSRIs)?

They are metabolized to active products with longer half-lives Signup and view all the answers

Which of the following is NOT a mechanism of action for most antidepressants?

Inhibition of monoamine oxidase (MAO) Signup and view all the answers

Which class of antidepressant drugs has the highest potential for drug interactions?

Selective serotonin reuptake inhibitors (SSRIs) Signup and view all the answers

Which of the following is a characteristic of tricyclic antidepressants (TCAs)?

They are substrates of the CYP2D6 system Signup and view all the answers

Which hypothesis suggests that neurotrophic and endocrine factors play a major role in the pathophysiology of major depression?

Neurotrophic hypothesis Signup and view all the answers

Which of the following is a characteristic of monoamine oxidase inhibitors (MAOIs)?

They have extensive first-pass effects Signup and view all the answers

Which of the following is a characteristic of bupropion?

It reduces the severity of nicotine cravings and withdrawal symptoms. Signup and view all the answers

Which of the following is a characteristic of mirtazapine?

It is a potent antagonist of 5-HT2 and 5-HT3 receptors. Signup and view all the answers

What can happen if monoamine oxidase inhibitors (MAOIs) are taken with tyramine-rich foods or sympathomimetics?

Hypertensive crisis can develop. Signup and view all the answers

Which of the following is a side effect of mirtazapine?

Dry mouth Signup and view all the answers

Which of the following is a characteristic of tetracyclic antidepressants?

They resemble desipramine with less sedative and antimuscarinic side effects. Signup and view all the answers

Which of the following is a characteristic of selective serotonin reuptake inhibitors (SSRIs)?

They up-regulate or enhance post-synaptic transmission at 5HT1A receptors. Signup and view all the answers

Master the Basics of Selective Serotonin Reuptake Inhibitors (SSRIs) with this Q...

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Questions and Answers

Which of the following is the primary indication for antidepressant agents?

According to the Centers for Disease Control and Prevention, what were the most commonly prescribed medications in the USA?

What is the lifetime prevalence of major depression in the USA?

What is the point prevalence of major depression in the USA?

According to the learning objectives, which classes of antidepressant drugs are listed?

What is the primary cellular target of antidepressant drugs?

Which of the following is a common side effect of tricyclic antidepressants (TCAs)?

Which of the following is a characteristic of tertiary TCAs?

Which of the following is a side effect of nefazodone?

Which of the following is a characteristic of trazodone?

Which of the following is an example of a heterocyclic tetracyclic antidepressant?

Which of the following is a characteristic of amoxapine?

Which of the following is NOT a disorder for which antidepressants have received FDA approval?

Which hypothesis suggests that a deficit in function or amount of monoamines is central to the biology of depression?

Which mechanism is shared by almost all antidepressants?

Which class of antidepressant drugs inhibits the enzymatic degradation of monoamines?

Which selective serotonin reuptake inhibitor (SSRI) has the longest half-life?

Which antidepressant class has relatively long half-lives ranging from 18 to 70 hours?

Which of the following is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

Which SSRI has a long half-life and a decreased incidence of discontinuation syndromes?

Which of the following can be a disadvantage of fluoxetine due to its long half-life?

Which class of antidepressants inhibits both serotonin and noradrenergic reuptake?

Which SNRI has minimal drug interactions and almost no P450 activity?

Which SNRI is indicated for major depressive disorder, diabetic peripheral neuropathic pain, and generalized anxiety disorder?

Which of the following is a characteristic of bupropion?

What is the mechanism by which bupropion enhances the ability of patients to abstain from smoking?

Which of the following is a characteristic of mirtazapine?

What is a potential side effect of mirtazapine?

Which of the following is true about monoamine oxidase inhibitors (MAOIs)?

What can happen if MAOIs are taken with tyramine-rich foods or sympathomimetics?

Which of the following is NOT a major class of antidepressant drugs?

Which of the following is a primary cellular target of antidepressant drugs?

Which of the following is a common therapeutic indication for antidepressant drugs?

Which of the following is a common adverse effect of classical antidepressants?

Which of the following is a potential interaction of St. John's wort with other antidepressant drugs?

What is the prevalence of major depression in the USA?

Which of the following is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

Which SNRI has minimal drug interactions and almost no P450 activity?

What is a potential side effect of mirtazapine?

Which SSRI has a long half-life and a decreased incidence of discontinuation syndromes?

Which of the following is a characteristic of bupropion?

Which of the following is a characteristic of trazodone?

Which of the following is a side effect of tricyclic antidepressants (TCAs)?

Which of the following is a potential serious side effect of tricyclic antidepressants (TCAs)?

Which of the following antidepressants is associated with priapism as a serious side effect?

Which of the following antidepressants is a weak inhibitor of both serotonin and norepinephrine reuptake?

Which of the following antidepressants is a metabolite of Loxapine and retains some antipsychotic activity?

Which of the following antidepressants is primarily used for unipolar depression, anxiety disorder, and insomnia?

Which of the following is a characteristic of selective serotonin reuptake inhibitors (SSRIs)?

Which of the following is NOT a mechanism of action for most antidepressants?

Which class of antidepressant drugs has the highest potential for drug interactions?

Which of the following is a characteristic of tricyclic antidepressants (TCAs)?

Which hypothesis suggests that neurotrophic and endocrine factors play a major role in the pathophysiology of major depression?

Which of the following is a characteristic of monoamine oxidase inhibitors (MAOIs)?

Which of the following is a characteristic of bupropion?

Which of the following is a characteristic of mirtazapine?

What can happen if monoamine oxidase inhibitors (MAOIs) are taken with tyramine-rich foods or sympathomimetics?

Which of the following is a side effect of mirtazapine?

Which of the following is a characteristic of tetracyclic antidepressants?

Which of the following is a characteristic of selective serotonin reuptake inhibitors (SSRIs)?

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