Master the Basics of Selective Serotonin Reuptake Inhibitors (SSRIs) with this Q...
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Questions and Answers

Which of the following is the primary indication for antidepressant agents?

  • Treatment of schizophrenia
  • Treatment of anxiety disorders
  • Treatment of major depressive disorder (correct)
  • Treatment of bipolar disorder

    • According to the Centers for Disease Control and Prevention, what were the most commonly prescribed medications in the USA?

  • Antipsychotic drugs
  • Antidepressant drugs (correct)
  • Antibiotics
  • Antiepileptic drugs

    • What is the lifetime prevalence of major depression in the USA?

  • Around 5%
  • Around 25%
  • Around 10%
  • Around 17% (correct)

    • What is the point prevalence of major depression in the USA?

    <p>5%</p> Signup and view all the answers

    According to the learning objectives, which classes of antidepressant drugs are listed?

    <p>Tricyclic ADs, SSRIs, SNRIs, heterocyclic antidepressants, and MAO inhibitors</p> Signup and view all the answers

    What is the primary cellular target of antidepressant drugs?

    <p>Serotonin receptors</p> Signup and view all the answers

    Which of the following is a common side effect of tricyclic antidepressants (TCAs)?

    <p>Excessive sweating</p> Signup and view all the answers

    Which of the following is a characteristic of tertiary TCAs?

    <p>They have active metabolites</p> Signup and view all the answers

    Which of the following is a side effect of nefazodone?

    <p>Hepatotoxicity</p> Signup and view all the answers

    Which of the following is a characteristic of trazodone?

    <p>It can cause priapism</p> Signup and view all the answers

    Which of the following is an example of a heterocyclic tetracyclic antidepressant?

    <p>Mirtazapine</p> Signup and view all the answers

    Which of the following is a characteristic of amoxapine?

    <p>It is a metabolite of loxapine</p> Signup and view all the answers

    Which of the following is NOT a disorder for which antidepressants have received FDA approval?

    <p>Post-traumatic stress disorder</p> Signup and view all the answers

    Which hypothesis suggests that a deficit in function or amount of monoamines is central to the biology of depression?

    <p>Monoamine hypothesis</p> Signup and view all the answers

    Which mechanism is shared by almost all antidepressants?

    <p>Inhibition of the activity of serotonin transporter (SERT)</p> Signup and view all the answers

    Which class of antidepressant drugs inhibits the enzymatic degradation of monoamines?

    <p>MAO inhibitors (MAOIs)</p> Signup and view all the answers

    Which selective serotonin reuptake inhibitor (SSRI) has the longest half-life?

    <p>Fluoxetine</p> Signup and view all the answers

    Which antidepressant class has relatively long half-lives ranging from 18 to 70 hours?

    <p>Tricyclic Antidepressants (TCAs)</p> Signup and view all the answers

    Which of the following is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

    <p>Headache</p> Signup and view all the answers

    Which SSRI has a long half-life and a decreased incidence of discontinuation syndromes?

    <p>Fluoxetine</p> Signup and view all the answers

    Which of the following can be a disadvantage of fluoxetine due to its long half-life?

    <p>Induction of mania</p> Signup and view all the answers

    Which class of antidepressants inhibits both serotonin and noradrenergic reuptake?

    <p>Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)</p> Signup and view all the answers

    Which SNRI has minimal drug interactions and almost no P450 activity?

    <p>Desvenlafaxine</p> Signup and view all the answers

    Which SNRI is indicated for major depressive disorder, diabetic peripheral neuropathic pain, and generalized anxiety disorder?

    <p>Duloxetine</p> Signup and view all the answers

    Which of the following is a characteristic of bupropion?

    <p>It lowers seizure threshold.</p> Signup and view all the answers

    What is the mechanism by which bupropion enhances the ability of patients to abstain from smoking?

    <p>Noradrenergic and/or dopaminergic mechanisms.</p> Signup and view all the answers

    Which of the following is a characteristic of mirtazapine?

    <p>It is a potent agonist of histamine (H1) receptors.</p> Signup and view all the answers

    What is a potential side effect of mirtazapine?

    <p>Increased sedation at higher doses.</p> Signup and view all the answers

    Which of the following is true about monoamine oxidase inhibitors (MAOIs)?

    <p>They cause a decrease in brain amine levels.</p> Signup and view all the answers

    What can happen if MAOIs are taken with tyramine-rich foods or sympathomimetics?

    <p>Orthostatic hypotension.</p> Signup and view all the answers

    Which of the following is NOT a major class of antidepressant drugs?

    <p>Heterocyclics antidepressants</p> Signup and view all the answers

    Which of the following is a primary cellular target of antidepressant drugs?

    <p>Transporters</p> Signup and view all the answers

    Which of the following is a common therapeutic indication for antidepressant drugs?

    <p>Anxiety disorders</p> Signup and view all the answers

    Which of the following is a common adverse effect of classical antidepressants?

    <p>Insomnia</p> Signup and view all the answers

    Which of the following is a potential interaction of St. John's wort with other antidepressant drugs?

    <p>Decreased efficacy</p> Signup and view all the answers

    What is the prevalence of major depression in the USA?

    <p>17%</p> Signup and view all the answers

    Which of the following is a common side effect of Selective Serotonin Reuptake Inhibitors (SSRIs)?

    <p>Insomnia</p> Signup and view all the answers

    Which SNRI has minimal drug interactions and almost no P450 activity?

    <p>Desvenlafaxine</p> Signup and view all the answers

    What is a potential side effect of mirtazapine?

    <p>Nausea</p> Signup and view all the answers

    Which SSRI has a long half-life and a decreased incidence of discontinuation syndromes?

    <p>Fluoxetine</p> Signup and view all the answers

    Which of the following is a characteristic of bupropion?

    <p>Minimal drug interactions</p> Signup and view all the answers

    Which of the following is a characteristic of trazodone?

    <p>Causes sexual side effects</p> Signup and view all the answers

    Which of the following is a side effect of tricyclic antidepressants (TCAs)?

    <p>Dry mouth</p> Signup and view all the answers

    Which of the following is a potential serious side effect of tricyclic antidepressants (TCAs)?

    <p>Orthostatic hypotension</p> Signup and view all the answers

    Which of the following antidepressants is associated with priapism as a serious side effect?

    <p>Trazodone</p> Signup and view all the answers

    Which of the following antidepressants is a weak inhibitor of both serotonin and norepinephrine reuptake?

    <p>Nefazodone</p> Signup and view all the answers

    Which of the following antidepressants is a metabolite of Loxapine and retains some antipsychotic activity?

    <p>Amoxapine</p> Signup and view all the answers

    Which of the following antidepressants is primarily used for unipolar depression, anxiety disorder, and insomnia?

    <p>Trazodone</p> Signup and view all the answers

    Which of the following is a characteristic of selective serotonin reuptake inhibitors (SSRIs)?

    <p>They are metabolized to active products with longer half-lives</p> Signup and view all the answers

    Which of the following is NOT a mechanism of action for most antidepressants?

    <p>Inhibition of monoamine oxidase (MAO)</p> Signup and view all the answers

    Which class of antidepressant drugs has the highest potential for drug interactions?

    <p>Selective serotonin reuptake inhibitors (SSRIs)</p> Signup and view all the answers

    Which of the following is a characteristic of tricyclic antidepressants (TCAs)?

    <p>They are substrates of the CYP2D6 system</p> Signup and view all the answers

    Which hypothesis suggests that neurotrophic and endocrine factors play a major role in the pathophysiology of major depression?

    <p>Neurotrophic hypothesis</p> Signup and view all the answers

    Which of the following is a characteristic of monoamine oxidase inhibitors (MAOIs)?

    <p>They have extensive first-pass effects</p> Signup and view all the answers

    Which of the following is a characteristic of bupropion?

    <p>It reduces the severity of nicotine cravings and withdrawal symptoms.</p> Signup and view all the answers

    Which of the following is a characteristic of mirtazapine?

    <p>It is a potent antagonist of 5-HT2 and 5-HT3 receptors.</p> Signup and view all the answers

    What can happen if monoamine oxidase inhibitors (MAOIs) are taken with tyramine-rich foods or sympathomimetics?

    <p>Hypertensive crisis can develop.</p> Signup and view all the answers

    Which of the following is a side effect of mirtazapine?

    <p>Dry mouth</p> Signup and view all the answers

    Which of the following is a characteristic of tetracyclic antidepressants?

    <p>They resemble desipramine with less sedative and antimuscarinic side effects.</p> Signup and view all the answers

    Which of the following is a characteristic of selective serotonin reuptake inhibitors (SSRIs)?

    <p>They up-regulate or enhance post-synaptic transmission at 5HT1A receptors.</p> Signup and view all the answers

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