15 Questions
What is the mode of action of antidepressants?
Inhibiting the reuptake of neurotransmitters
What is a potential indication for using antidepressants?
Depression with anxiety and panic disorders
What is a potential pharmacokinetic characteristic of antidepressants?
Metabolism by CYP450 enzymes
What is a potential side effect of antidepressants related to their anticholinergic activity?
Blurred vision and dry mouth
What is a notable contraindication for using antidepressants?
Prostate hyperplasia
What is a potential effect of abrupt discontinuation of high doses of antidepressants?
Occasional withdrawal syndrome
Which class of drugs is known for blocking norepinephrine and serotonin reuptake into the presynaptic neuron?
Tricyclic antidepressants (TCAs)
What is the main mode of action of selective serotonin reuptake inhibitors (SSRIs)?
Increase concentration of serotonin in the synaptic cleft
Which side effect is associated with tricyclic antidepressants (TCAs)?
Inappropriate antidiuretic hormone (ADH) secretion (SIADH)
What is the pharmacokinetic characteristic of new generation drugs used for depression?
Do not require monitoring due to low toxicity
Which neurotransmitters are mainly affected by monoamine oxidase inhibitors (MAOIs)?
Norepinephrine and serotonin
What is the primary indication for new generation drugs used in depression?
Depression and anxiety disorders
What is the effect of tricyclic antidepressants (TCAs) on neurotransmitter concentration in the synaptic cleft?
Increase concentration of norepinephrine and serotonin
Which class of drugs is known for down-regulating %-HT1 autoreceptors to increase brain-derived neurotrophic factor (BDNF)?
Selective serotonin reuptake inhibitors (SSRIs)
What is a potential side effect of selective serotonin reuptake inhibitors (SSRIs) that may lead to easy bruising and bleeding?
Decreased platelet function
Test your knowledge of antidepressant drugs by taking this quiz about their mode of action, indications, contraindications, pharmacokinetics, and side effects. Explore topics such as drug interactions, prescription requirements, and specific conditions for which antidepressants are used.
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