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Antidepressant Drugs: Mode of Action and Indications Quiz

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Antidepressant Drugs: Mode of Action and Indications Quiz

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Questions and Answers

What is the mode of action of antidepressants?

Increasing the production of dopamine

Blocking the action of GABA receptors

Inhibiting the reuptake of neurotransmitters (correct)

Stimulating the release of serotonin and norepinephrine

What is a potential indication for using antidepressants?

Depression with anxiety and panic disorders (correct)

Moderate to severe depression only

Bipolar disorders only

Mild depression only

What is a potential pharmacokinetic characteristic of antidepressants?

Poor absorption when taken orally

Low lipid solubility leading to poor BBB penetration

Short half-life and rapid excretion in urine

Metabolism by CYP450 enzymes (correct)

What is a potential side effect of antidepressants related to their anticholinergic activity?

Blurred vision and dry mouth Signup and view all the answers

What is a notable contraindication for using antidepressants?

Prostate hyperplasia Signup and view all the answers

What is a potential effect of abrupt discontinuation of high doses of antidepressants?

Occasional withdrawal syndrome Signup and view all the answers

Which class of drugs is known for blocking norepinephrine and serotonin reuptake into the presynaptic neuron?

Tricyclic antidepressants (TCAs) Signup and view all the answers

What is the main mode of action of selective serotonin reuptake inhibitors (SSRIs)?

Increase concentration of serotonin in the synaptic cleft Signup and view all the answers

Which side effect is associated with tricyclic antidepressants (TCAs)?

Inappropriate antidiuretic hormone (ADH) secretion (SIADH) Signup and view all the answers

What is the pharmacokinetic characteristic of new generation drugs used for depression?

Do not require monitoring due to low toxicity Signup and view all the answers

Which neurotransmitters are mainly affected by monoamine oxidase inhibitors (MAOIs)?

Norepinephrine and serotonin Signup and view all the answers

What is the primary indication for new generation drugs used in depression?

Depression and anxiety disorders Signup and view all the answers

What is the effect of tricyclic antidepressants (TCAs) on neurotransmitter concentration in the synaptic cleft?

Increase concentration of norepinephrine and serotonin Signup and view all the answers

Which class of drugs is known for down-regulating %-HT1 autoreceptors to increase brain-derived neurotrophic factor (BDNF)?

Selective serotonin reuptake inhibitors (SSRIs) Signup and view all the answers

What is a potential side effect of selective serotonin reuptake inhibitors (SSRIs) that may lead to easy bruising and bleeding?

Decreased platelet function Signup and view all the answers