Podcast
Questions and Answers
What is the mode of action of antidepressants?
What is the mode of action of antidepressants?
- Increasing the production of dopamine
- Blocking the action of GABA receptors
- Inhibiting the reuptake of neurotransmitters (correct)
- Stimulating the release of serotonin and norepinephrine
What is a potential indication for using antidepressants?
What is a potential indication for using antidepressants?
- Depression with anxiety and panic disorders (correct)
- Moderate to severe depression only
- Bipolar disorders only
- Mild depression only
What is a potential pharmacokinetic characteristic of antidepressants?
What is a potential pharmacokinetic characteristic of antidepressants?
- Poor absorption when taken orally
- Low lipid solubility leading to poor BBB penetration
- Short half-life and rapid excretion in urine
- Metabolism by CYP450 enzymes (correct)
What is a potential side effect of antidepressants related to their anticholinergic activity?
What is a potential side effect of antidepressants related to their anticholinergic activity?
What is a notable contraindication for using antidepressants?
What is a notable contraindication for using antidepressants?
What is a potential effect of abrupt discontinuation of high doses of antidepressants?
What is a potential effect of abrupt discontinuation of high doses of antidepressants?
Which class of drugs is known for blocking norepinephrine and serotonin reuptake into the presynaptic neuron?
Which class of drugs is known for blocking norepinephrine and serotonin reuptake into the presynaptic neuron?
What is the main mode of action of selective serotonin reuptake inhibitors (SSRIs)?
What is the main mode of action of selective serotonin reuptake inhibitors (SSRIs)?
Which side effect is associated with tricyclic antidepressants (TCAs)?
Which side effect is associated with tricyclic antidepressants (TCAs)?
What is the pharmacokinetic characteristic of new generation drugs used for depression?
What is the pharmacokinetic characteristic of new generation drugs used for depression?
Which neurotransmitters are mainly affected by monoamine oxidase inhibitors (MAOIs)?
Which neurotransmitters are mainly affected by monoamine oxidase inhibitors (MAOIs)?
What is the primary indication for new generation drugs used in depression?
What is the primary indication for new generation drugs used in depression?
What is the effect of tricyclic antidepressants (TCAs) on neurotransmitter concentration in the synaptic cleft?
What is the effect of tricyclic antidepressants (TCAs) on neurotransmitter concentration in the synaptic cleft?
Which class of drugs is known for down-regulating %-HT1 autoreceptors to increase brain-derived neurotrophic factor (BDNF)?
Which class of drugs is known for down-regulating %-HT1 autoreceptors to increase brain-derived neurotrophic factor (BDNF)?
What is a potential side effect of selective serotonin reuptake inhibitors (SSRIs) that may lead to easy bruising and bleeding?
What is a potential side effect of selective serotonin reuptake inhibitors (SSRIs) that may lead to easy bruising and bleeding?
Flashcards
How do antidepressants work?
How do antidepressants work?
Antidepressants work by preventing the reuptake of neurotransmitters, which increases their levels in the synapse.
What are some common uses for antidepressants?
What are some common uses for antidepressants?
Depression, anxiety, and panic disorders are common conditions where antidepressants are used.
How are antidepressants processed in the body?
How are antidepressants processed in the body?
Many antidepressants are metabolized by the CYP450 enzymes, which are involved in breaking down drugs in the liver.
What are some possible side effects of antidepressants?
What are some possible side effects of antidepressants?
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When should antidepressants be avoided?
When should antidepressants be avoided?
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What happens if you stop taking antidepressants suddenly?
What happens if you stop taking antidepressants suddenly?
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How do tricyclic antidepressants work?
How do tricyclic antidepressants work?
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How do SSRIs work?
How do SSRIs work?
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What is a notable side effect of TCAs?
What is a notable side effect of TCAs?
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What is special about newer antidepressants?
What is special about newer antidepressants?
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How do MAOIs work?
How do MAOIs work?
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What are new generation antidepressants used for?
What are new generation antidepressants used for?
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How do TCAs affect neurotransmitter levels?
How do TCAs affect neurotransmitter levels?
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How do SSRIs affect brain growth?
How do SSRIs affect brain growth?
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What is a potential side effect of SSRIs related to bleeding?
What is a potential side effect of SSRIs related to bleeding?
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