Questions and Answers
What does the retrospective evaluation of children with Marfan syndrome suggest about beta-blocker treatment?
It was associated with a reduced aortic growth rate
What did randomized trials comparing an ARB to a beta blocker in patients with Marfan syndrome find?
No significant difference in aortic root growth rate or clinical events between the 2 treatment groups
What did multiple trials comparing the addition of an ARB to beta-blocker therapy in patients with Marfan syndrome show?
Reduction of aortic root growth rates over a 3- to 5-year follow-up
What was the outcome of losartan treatment in a small, nonrandomized open-label study of children with Marfan syndrome who had previously had rapid aortic root growth?
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What did a meta-analysis confirm about combination therapy of ARB and beta-blocker in patients with Marfan syndrome?
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What is the approximate reoperation rate over 20 years for adult patients with certain cardiac conditions?
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What should symptoms like dyspnea, fatigue, edema, or ascites in adult patients indicate?
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What is the likely consequence of recurrent stenosis in adult patients?
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What is the potential implication of ventricular dysfunction precluding further surgery in adult patients?
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What may preclude heart transplantation in adult patients?
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