Marfan Syndrome: TGF-β Signaling
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Questions and Answers

What is the main reason behind the overgrowth of bones in Marfan syndrome?

  • Genetic mutations in bone cells
  • Decreased production of fibrillin
  • Increased synthesis of TGF-β
  • Loss of microfibrils leading to abnormal activation of TGF-β (correct)

    • How do normal microfibrils affect the availability of TGF-β?

  • They sequester TGF-β, controlling its bioavailability (correct)
  • They have no impact on the availability of TGF-β
  • They degrade TGF-β molecules
  • They promote the release of TGF-β

    • Which system is primarily affected by excessive TGF-β in Marfan syndrome?

  • Vascular smooth muscle system (correct)
  • Digestive system
  • Respiratory system
  • Nervous system

    • What ocular abnormalities are commonly observed in individuals with Marfan syndrome?

    <p>Frequent myopia and detached lens</p> Signup and view all the answers

    Which cardiovascular diseases are associated with Marfan syndrome?

    <p>Mitral valve prolapse, aortic aneurysm, dilatation of ascending aorta</p> Signup and view all the answers

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