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Questions and Answers
What is the main reason behind the overgrowth of bones in Marfan syndrome?
What is the main reason behind the overgrowth of bones in Marfan syndrome?
- Genetic mutations in bone cells
- Decreased production of fibrillin
- Increased synthesis of TGF-β
- Loss of microfibrils leading to abnormal activation of TGF-β (correct)
How do normal microfibrils affect the availability of TGF-β?
How do normal microfibrils affect the availability of TGF-β?
- They sequester TGF-β, controlling its bioavailability (correct)
- They have no impact on the availability of TGF-β
- They degrade TGF-β molecules
- They promote the release of TGF-β
Which system is primarily affected by excessive TGF-β in Marfan syndrome?
Which system is primarily affected by excessive TGF-β in Marfan syndrome?
- Vascular smooth muscle system (correct)
- Digestive system
- Respiratory system
- Nervous system
What ocular abnormalities are commonly observed in individuals with Marfan syndrome?
What ocular abnormalities are commonly observed in individuals with Marfan syndrome?
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Which cardiovascular diseases are associated with Marfan syndrome?
Which cardiovascular diseases are associated with Marfan syndrome?
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