Podcast
Questions and Answers
What is the primary purpose of size enlargement in industrial pharmacy?
What is the primary purpose of size enlargement in industrial pharmacy?
- To reduce the cost of raw materials
- To facilitate faster chemical reactions
- To decrease the overall weight of the product
- To prevent dust losses in subsequent treatment steps (correct)
Which of the following is NOT a method of size enlargement?
Which of the following is NOT a method of size enlargement?
- Sintering (correct)
- Coating
- Compression
- Flocculation
How does wet granulation primarily differ from dry granulation?
How does wet granulation primarily differ from dry granulation?
- Wet granulation utilizes liquid in the process (correct)
- Wet granulation uses heat while dry does not
- Wet granulation is faster than dry granulation
- Wet granulation can only be done in large batches
What is a significant advantage of increasing the bulk density of materials?
What is a significant advantage of increasing the bulk density of materials?
Which type of granulation involves massing powder with a non-toxic solvent?
Which type of granulation involves massing powder with a non-toxic solvent?
What is the main disadvantage of high surface area in hygroscopic substances?
What is the main disadvantage of high surface area in hygroscopic substances?
In granulation by fusion, what is the key component used to agglomerate mixtures?
In granulation by fusion, what is the key component used to agglomerate mixtures?
Which method involves granulation by introducing a suitable spray of granulating liquid?
Which method involves granulation by introducing a suitable spray of granulating liquid?
What is the main advantage of dry granulation techniques like slugging compared to wet granulation?
What is the main advantage of dry granulation techniques like slugging compared to wet granulation?
Which equipment is specifically used in spheronisation for producing spherical pellets?
Which equipment is specifically used in spheronisation for producing spherical pellets?
What does the roller compaction method utilize to form compressed sheets?
What does the roller compaction method utilize to form compressed sheets?
Which statement about wet granulation is FALSE?
Which statement about wet granulation is FALSE?
What is slugs in the context of dry granulation?
What is slugs in the context of dry granulation?
Which of the following is NOT a piece of equipment used in wet granulation?
Which of the following is NOT a piece of equipment used in wet granulation?
What characterizes the resultant granules produced in granulation techniques?
What characterizes the resultant granules produced in granulation techniques?
Which of the following granulation methods is most applicable for active ingredients that are sensitive to moisture?
Which of the following granulation methods is most applicable for active ingredients that are sensitive to moisture?
Flashcards
Size Enlargement
Size Enlargement
Process of increasing the size of particles beyond their original components.
Granulation
Granulation
Method of forming granules (small lumps or pellets) from powder.
Wet Granulation
Wet Granulation
Granulation method using a liquid binder to stick particles together.
Dry Granulation
Dry Granulation
Signup and view all the flashcards
Shear Granulation
Shear Granulation
Signup and view all the flashcards
Granulation by Fusion
Granulation by Fusion
Signup and view all the flashcards
Spray Granulation
Spray Granulation
Signup and view all the flashcards
Objectives of Size Enlargement
Objectives of Size Enlargement
Signup and view all the flashcards
Granulation
Granulation
Signup and view all the flashcards
Wet Granulation
Wet Granulation
Signup and view all the flashcards
Dry Granulation
Dry Granulation
Signup and view all the flashcards
Slugging
Slugging
Signup and view all the flashcards
Roller Compaction
Roller Compaction
Signup and view all the flashcards
Extrusion Granulation
Extrusion Granulation
Signup and view all the flashcards
Spheronisation
Spheronisation
Signup and view all the flashcards
Equipment for Granulation
Equipment for Granulation
Signup and view all the flashcards
Study Notes
Manufacturing Pharmacy (II) - PHCT 503
- Course is about Manufacturing Pharmacy (II)
- Professor Dr. Mohamed Farid El-Miligi is the "GOD Father of Industrial Pharmacy" from MUST University and Cairo University
- Size enlargement deals with making portions of matter larger than component particles
- Methods include granulation, flocculation, extrusion, compression, and coating
- Objectives of size enlargement include: -preventing air trapping in tableting and varying powder densities -increasing flowability in hoppers and dies -increasing bulk density for easier storage and transportation -preventing dust losses during drying, filling, or shipping -reducing dust nuisance and hazard -reducing surface area for hygroscopic or reactive substances to minimize water absorption and enhance stability
Granulation Methods
- Granulation methods are divided into two types: -Wet methods (using liquid) -Dry methods (no liquid)
A. Wet Granulation
- Involves massing powder mix using a non-toxic and volatile solvent
- Methods include: -Shear granulation (using a planetary mixer like Hobart Mixer) -Granulation by fusion (using suitable wax binders) -Spray granulation (by introducing granulating liquid and drying) -Granulation by extrusion (similar to mincing meat) -Granulation by spheronisation (using spheronising or pelletising equipment like Freund Granulator)
B. Dry Granulation
- Methods include: -Slugging by Tablet Presses (compressing powder into dies of a tablet press) -Roller Compaction (feeding the powder between rollers to form compressed sheets)
- Used when active ingredients are sensitive to moisture, heat, or both
Equipment
- A. Wet Granulators: -Oscillating Granulator -Reciprocating Horizontal Granulator -Perforated Roller Granulator -Perforated Basket Granulator -Fluidized-Bed Granulator -Extruder -Freund Granulator
- B. Dry Granulators: -Slugging Tablet Press -Chilsonator
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Dive into the world of Manufacturing Pharmacy with this quiz, focusing on size enlargement techniques such as granulation and coating. Learn about methods that enhance powder properties to facilitate easier storage, transportation, and processing. Explore the detailed objectives and advantages of these methods in pharmaceutical manufacturing.
