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Questions and Answers
What is the primary purpose of size enlargement in industrial pharmacy?
Which of the following is NOT a method of size enlargement?
How does wet granulation primarily differ from dry granulation?
What is a significant advantage of increasing the bulk density of materials?
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Which type of granulation involves massing powder with a non-toxic solvent?
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What is the main disadvantage of high surface area in hygroscopic substances?
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In granulation by fusion, what is the key component used to agglomerate mixtures?
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Which method involves granulation by introducing a suitable spray of granulating liquid?
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What is the main advantage of dry granulation techniques like slugging compared to wet granulation?
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Which equipment is specifically used in spheronisation for producing spherical pellets?
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What does the roller compaction method utilize to form compressed sheets?
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Which statement about wet granulation is FALSE?
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What is slugs in the context of dry granulation?
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Which of the following is NOT a piece of equipment used in wet granulation?
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What characterizes the resultant granules produced in granulation techniques?
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Which of the following granulation methods is most applicable for active ingredients that are sensitive to moisture?
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Study Notes
Manufacturing Pharmacy (II) - PHCT 503
- Course is about Manufacturing Pharmacy (II)
- Professor Dr. Mohamed Farid El-Miligi is the "GOD Father of Industrial Pharmacy" from MUST University and Cairo University
- Size enlargement deals with making portions of matter larger than component particles
- Methods include granulation, flocculation, extrusion, compression, and coating
- Objectives of size enlargement include: -preventing air trapping in tableting and varying powder densities -increasing flowability in hoppers and dies -increasing bulk density for easier storage and transportation -preventing dust losses during drying, filling, or shipping -reducing dust nuisance and hazard -reducing surface area for hygroscopic or reactive substances to minimize water absorption and enhance stability
Granulation Methods
- Granulation methods are divided into two types: -Wet methods (using liquid) -Dry methods (no liquid)
A. Wet Granulation
- Involves massing powder mix using a non-toxic and volatile solvent
- Methods include: -Shear granulation (using a planetary mixer like Hobart Mixer) -Granulation by fusion (using suitable wax binders) -Spray granulation (by introducing granulating liquid and drying) -Granulation by extrusion (similar to mincing meat) -Granulation by spheronisation (using spheronising or pelletising equipment like Freund Granulator)
B. Dry Granulation
- Methods include: -Slugging by Tablet Presses (compressing powder into dies of a tablet press) -Roller Compaction (feeding the powder between rollers to form compressed sheets)
- Used when active ingredients are sensitive to moisture, heat, or both
Equipment
- A. Wet Granulators: -Oscillating Granulator -Reciprocating Horizontal Granulator -Perforated Roller Granulator -Perforated Basket Granulator -Fluidized-Bed Granulator -Extruder -Freund Granulator
- B. Dry Granulators: -Slugging Tablet Press -Chilsonator
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Description
Dive into the world of Manufacturing Pharmacy with this quiz, focusing on size enlargement techniques such as granulation and coating. Learn about methods that enhance powder properties to facilitate easier storage, transportation, and processing. Explore the detailed objectives and advantages of these methods in pharmaceutical manufacturing.
