Managing Critically Ill Patients with MDR S.maltophilia Infections
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Questions and Answers

What is the primary goal of the review regarding pan-drug resistant MDR S. maltophilia in critically ill patients with HAP/VAP?

  • To present strategies for effective antibiotic treatment (correct)
  • To discuss the risk factors associated with mortality rates
  • To investigate the genetic mechanisms of antibiotic resistance
  • To evaluate the efficacy of broad-spectrum agents
  • What type of bacteria is Stenotrophomonas (S.) spp?

  • Non-fermentative Gram-negative bacteria (correct)
  • Fermentative Gram-positive bacteria
  • Non-fermentative Gram-positive bacteria
  • Fermentative Gram-negative bacteria
  • Why has the clinical management of MDR GNB infections become more complex?

  • Due to the high levels of resistance expressed by the bacteria (correct)
  • Due to the decreased efficacy of broad-spectrum agents
  • Due to the increased occurrence of colonized patients
  • Due to the development of new antibiotic agents
  • What is a common characteristic of MDR GNB, including S. maltophilia?

    <p>Expression of high levels of resistance</p> Signup and view all the answers

    What was the cutoff date for the search of published studies in the review?

    <p>April 2019</p> Signup and view all the answers

    What is a common risk factor associated with HAP/VAP due to S. maltophilia?

    <p>Specific risk conditions</p> Signup and view all the answers

    What is the significance of Stenotrophomonas (S.) spp. in the context of nosocomial and community-acquired infections?

    <p>It is a noticeable microbe of nosocomial and community-acquired infections</p> Signup and view all the answers

    What is the consequence of the increasing resistance of S. maltophilia isolates?

    <p>Healthcare facilities experience an ingathering of colonized patients</p> Signup and view all the answers

    Study Notes

    Objectives of the Review

    • Discuss current data and outcomes for managing and treating critically ill patients with Hospital-Acquired Pneumonia (HAP) and Ventilator-Associated Pneumonia (VAP) caused by pan-drug resistant Multidrug-Resistant (MDR) Stenotrophomonas maltophilia.
    • Present strategies for effective antibiotic treatment against MDR S. maltophilia isolates.
    • Review mortality rates and common influencing risk factors for patients with pan-resistance.

    Background and Context

    • Multidrug-Resistant Gram-Negative Bacteria (MDR GNB) infections have limited therapeutic options.
    • Pan-resistant phenotypes make clinical management more complex and challenging.
    • Stenotrophomonas (S.) maltophilia is a non-fermentative Gram-Negative Bacteria (GNB) causing nosocomial and community-acquired infections.
    • Despite broad-spectrum agents, S. maltophilia isolates have increased resistance, leading to colonization and infections in patients with specific risk conditions.

    Methodology

    • Performed a major search of online databases until April 2019.
    • Reviewed experimental and observational studies, online journals, and expert opinions on VAP/HAP due to S. maltophilia.

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    Description

    This quiz reviews current data and outcomes for managing critically ill patients with HAP/VAP due to pan-drug resistant MDR S.maltophilia, including effective antibiotic treatment strategies and mortality rates.

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