Questions and Answers
What is the primary goal of the review regarding pan-drug resistant MDR S. maltophilia in critically ill patients with HAP/VAP?
What type of bacteria is Stenotrophomonas (S.) spp?
Why has the clinical management of MDR GNB infections become more complex?
What is a common characteristic of MDR GNB, including S. maltophilia?
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What was the cutoff date for the search of published studies in the review?
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What is a common risk factor associated with HAP/VAP due to S. maltophilia?
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What is the significance of Stenotrophomonas (S.) spp. in the context of nosocomial and community-acquired infections?
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What is the consequence of the increasing resistance of S. maltophilia isolates?
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Study Notes
Objectives of the Review
- Discuss current data and outcomes for managing and treating critically ill patients with Hospital-Acquired Pneumonia (HAP) and Ventilator-Associated Pneumonia (VAP) caused by pan-drug resistant Multidrug-Resistant (MDR) Stenotrophomonas maltophilia.
- Present strategies for effective antibiotic treatment against MDR S. maltophilia isolates.
- Review mortality rates and common influencing risk factors for patients with pan-resistance.
Background and Context
- Multidrug-Resistant Gram-Negative Bacteria (MDR GNB) infections have limited therapeutic options.
- Pan-resistant phenotypes make clinical management more complex and challenging.
- Stenotrophomonas (S.) maltophilia is a non-fermentative Gram-Negative Bacteria (GNB) causing nosocomial and community-acquired infections.
- Despite broad-spectrum agents, S. maltophilia isolates have increased resistance, leading to colonization and infections in patients with specific risk conditions.
Methodology
- Performed a major search of online databases until April 2019.
- Reviewed experimental and observational studies, online journals, and expert opinions on VAP/HAP due to S. maltophilia.
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Description
This quiz reviews current data and outcomes for managing critically ill patients with HAP/VAP due to pan-drug resistant MDR S.maltophilia, including effective antibiotic treatment strategies and mortality rates.