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Questions and Answers
What is the default sexual differentiation in human embryos?
What is the default sexual differentiation in human embryos?
- Ambiguous
- Intersex
- Female (correct)
- Male
Which gene on the Y chromosome encodes for the development of the testes?
Which gene on the Y chromosome encodes for the development of the testes?
- Sex-determining region (SRY) gene (correct)
- Leydig gene
- Wolffian gene
- MIS gene
What do Sertoli cells produce to induce regression of the Mullerian ducts?
What do Sertoli cells produce to induce regression of the Mullerian ducts?
- Estrogen
- Testosterone
- Progesterone
- MIS (Mullerian inhibiting substance) (correct)
Which cells in the testes produce testosterone?
Which cells in the testes produce testosterone?
What does testosterone stimulate the development of in the male fetus?
What does testosterone stimulate the development of in the male fetus?
What defines differentiation into the male phenotype and the male reproductive system?
What defines differentiation into the male phenotype and the male reproductive system?
Which cells produce MIS to induce regression of the Mullerian ducts?
Which cells produce MIS to induce regression of the Mullerian ducts?
What is responsible for stimulating the development of the Wolffian ducts in the male fetus?
What is responsible for stimulating the development of the Wolffian ducts in the male fetus?
What is the major driver of male reproductive development?
What is the major driver of male reproductive development?
Where do the testes lie at maturity?
Where do the testes lie at maturity?
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Study Notes
Default Sexual Differentiation
- Human embryos initially follow a default female pathway before any sexual differentiation occurs.
Testes Development
- The SRY gene located on the Y chromosome is crucial for the development of testes.
Sertoli Cells
- Sertoli cells produce Müllerian Inhibiting Substance (MIS), which causes the regression of Müllerian ducts.
Testosterone Production
- Leydig cells within the testes are responsible for the production of testosterone.
Fetal Development
- Testosterone stimulates the development of male internal and external genitalia in the male fetus.
Male Phenotype Determination
- Differentiation into the male phenotype and formation of the male reproductive system are driven by the presence of testosterone and MIS.
MIS Production
- Sertoli cells are responsible for the production of Müllerian Inhibiting Substance (MIS), which leads to the regression of the Müllerian ducts.
Wolffian Duct Development
- The development of the Wolffian ducts in the male fetus is stimulated by testosterone.
Key Driver of Male Development
- Testosterone serves as the primary driver for male reproductive development during fetal maturation.
Location of Testes
- At maturity, the testes are located within the scrotum outside the body cavity.
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