Male Hypogonadism Objectives Review

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What is the proposed mechanism behind idiopathic central hypogonadism?

Decreased activity of the GnRH pulse generator (correct)

Dysfunction of the hypothalamic-pituitary-adrenal axis

Damage to the testicular axis

Increased activity of the GnRH pulse generator

At what time of day should serum testosterone concentrations be measured for diagnosing hypogonadism?

Evening (6-8 pm)

Any time of day

Morning (8-10 am) (correct)

Afternoon (2-4 pm)

What is the main goal of testosterone replacement therapy (TRT) in hypogonadal males?

To improve fertility

To treat osteoporosis

To improve symptoms and restore hormone levels to a normal range (correct)

To increase muscle mass

What is measured in addition to total serum testosterone in cases where sex hormone-binding globulin (SHBG) is suspected to be elevated?

Free testosterone Signup and view all the answers

What is the range of normal testosterone levels in males?

300-1000 ng/dL Signup and view all the answers

What is the treatment of choice for secondary hypogonadism to improve fertility?

GnRH treatment Signup and view all the answers

What is the primary function of GnRH in the hypothalamic-pituitary-testicular axis?

Stimulates the gonadotroph cells of the pituitary to secrete LH and FSH Signup and view all the answers

What is the main difference between primary and secondary hypogonadism?

Primary hypogonadism affects the testes, while secondary affects the pituitary gland Signup and view all the answers

What is the function of the anterior pituitary gland in the hypothalamic-pituitary-testicular axis?

Stimulates the production of FSH and LH Signup and view all the answers

What is the primary function of the hypothalamus in the hypothalamic-pituitary-testicular axis?

Produces GnRH and regulates the pituitary gland Signup and view all the answers

What is the main cause of primary hypogonadism?

Klinefelter's syndrome Signup and view all the answers

What is the role of FSH in the testes?

Regulates spermatogenesis Signup and view all the answers

What is the primary function of LH in the testes?

Stimulates the production of testosterone Signup and view all the answers

What is the role of the pituitary gland in the hypothalamic-pituitary-testicular axis?

Produces FSH and LH and regulates the testes Signup and view all the answers

What is the primary treatment option for infertility secondary to hypogonadism?

Assisted reproduction technology Signup and view all the answers

What is the primary parameter to monitor during testosterone replacement therapy?

Testosterone levels Signup and view all the answers

What is the primary mechanism by which hyperprolactinemia leads to hypogonadism?

Suppression of GnRH synthesis and secretion Signup and view all the answers

What is the most common genetic cause of isolated congenital gonadotropin deficiency?

Kallmann's syndrome Signup and view all the answers

Which of the following medications is known to suppress GnRH synthesis?

All of the above Signup and view all the answers

What is the effect of testicular torsion on the testes?

It leads to interruption of testicular perfusion Signup and view all the answers

What is the relationship between testosterone concentrations and the severity of illness?

Testosterone concentrations are inversely related to the severity of illness Signup and view all the answers

What is the effect of varicocele on the testes?

It leads to decreased spermatogenesis and testosterone production Signup and view all the answers