Male Hypogonadism Objectives Review
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Questions and Answers

What is the proposed mechanism behind idiopathic central hypogonadism?

  • Decreased activity of the GnRH pulse generator (correct)
  • Dysfunction of the hypothalamic-pituitary-adrenal axis
  • Damage to the testicular axis
  • Increased activity of the GnRH pulse generator

At what time of day should serum testosterone concentrations be measured for diagnosing hypogonadism?

  • Evening (6-8 pm)
  • Any time of day
  • Morning (8-10 am) (correct)
  • Afternoon (2-4 pm)

What is the main goal of testosterone replacement therapy (TRT) in hypogonadal males?

  • To improve fertility
  • To treat osteoporosis
  • To improve symptoms and restore hormone levels to a normal range (correct)
  • To increase muscle mass

What is measured in addition to total serum testosterone in cases where sex hormone-binding globulin (SHBG) is suspected to be elevated?

<p>Free testosterone (C)</p> Signup and view all the answers

What is the range of normal testosterone levels in males?

<p>300-1000 ng/dL (B)</p> Signup and view all the answers

What is the treatment of choice for secondary hypogonadism to improve fertility?

<p>GnRH treatment (B)</p> Signup and view all the answers

What is the primary function of GnRH in the hypothalamic-pituitary-testicular axis?

<p>Stimulates the gonadotroph cells of the pituitary to secrete LH and FSH (A)</p> Signup and view all the answers

What is the main difference between primary and secondary hypogonadism?

<p>Primary hypogonadism affects the testes, while secondary affects the pituitary gland (A)</p> Signup and view all the answers

What is the function of the anterior pituitary gland in the hypothalamic-pituitary-testicular axis?

<p>Stimulates the production of FSH and LH (B)</p> Signup and view all the answers

What is the primary function of the hypothalamus in the hypothalamic-pituitary-testicular axis?

<p>Produces GnRH and regulates the pituitary gland (B)</p> Signup and view all the answers

What is the main cause of primary hypogonadism?

<p>Klinefelter's syndrome (D)</p> Signup and view all the answers

What is the role of FSH in the testes?

<p>Regulates spermatogenesis (C)</p> Signup and view all the answers

What is the primary function of LH in the testes?

<p>Stimulates the production of testosterone (B)</p> Signup and view all the answers

What is the role of the pituitary gland in the hypothalamic-pituitary-testicular axis?

<p>Produces FSH and LH and regulates the testes (D)</p> Signup and view all the answers

What is the primary treatment option for infertility secondary to hypogonadism?

<p>Assisted reproduction technology (D)</p> Signup and view all the answers

What is the primary parameter to monitor during testosterone replacement therapy?

<p>Testosterone levels (C)</p> Signup and view all the answers

What is the primary mechanism by which hyperprolactinemia leads to hypogonadism?

<p>Suppression of GnRH synthesis and secretion (D)</p> Signup and view all the answers

What is the most common genetic cause of isolated congenital gonadotropin deficiency?

<p>Kallmann's syndrome (C)</p> Signup and view all the answers

Which of the following medications is known to suppress GnRH synthesis?

<p>All of the above (D)</p> Signup and view all the answers

What is the effect of testicular torsion on the testes?

<p>It leads to interruption of testicular perfusion (C)</p> Signup and view all the answers

What is the relationship between testosterone concentrations and the severity of illness?

<p>Testosterone concentrations are inversely related to the severity of illness (D)</p> Signup and view all the answers

What is the effect of varicocele on the testes?

<p>It leads to decreased spermatogenesis and testosterone production (C)</p> Signup and view all the answers

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