Malaria: Overview and Fundamentals

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18 Questions

What is the origin of the term 'malaria'?

Medieval Italian

What is the type of malaria that is most likely to result in severe infections?

P. falciparum

What is the estimated number of malaria cases worldwide in 2020?

241 million

What is the incidence of malaria per 1000 population at risk in Pakistan in 2020?

8.4

What is the primary mode of transmission of malaria?

Mosquito bites

What is the estimated number of malaria deaths worldwide in 2020?

627 000

What is the type of malaria that is transmitted from animal to human?

P.knowlesi

What is the purpose of the expression of certain surface sticky proteins on infected RBCs?

To facilitate the attachment of infected RBCs to the walls of vessels

What is the result of the activation of endothelial cells by cytokines?

The attachment of infected RBCs to the walls of vessels

What is the outcome of the mechanisms employed by infected RBCs to avoid the immune response?

Vascular clotting problems and occlusion

What is the result of the occlusion of blood vessels in malaria?

Ischemia of multiple vital organs

What is the role of macrophages in the pathophysiology of malaria?

To secrete cytokines, especially INF-a and INF-y

What is the specificity of the Rapid Diagnostic Test (RDT) for diagnosing malaria?

96.7%

What is the primary goal of administering primaquine in the treatment of malaria?

To prevent relapses

Which of the following diagnostic tests is quantitative?

Thick blood smear

What is the primary indication for performing a lumbar puncture in a malaria patient?

To diagnose cerebral malaria

Which of the following laboratory tests is not typically used to monitor treatment response in malaria?

G6PD levels

What is the primary reason for administering blood transfusion in a malaria patient?

To correct anemia

Test your knowledge on the basics of malaria, including its history, epidemiology, etiology, life cycle, pathophysiology, treatment, and preventive measures. Learn about the vulnerable and immune populations, and how to combat this serious and sometimes fatal disease.

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