12 Questions
Which genes code for molecules involved in immune responses in the human and mouse MHC?
Class II genes
What are the products of some of the genes involved in antigen processing in the MHC?
DM and proteasome components
Which genes encode molecules other than peptide display molecules in the MHC?
Complement protein genes and cytokines
Which region in the human and mouse MHC includes genes coding for D P, D M, proteasome genes, D Q, and D R?
Class II MHC locus region
What is the structure of class I MHC molecule?
Consists of an α chain noncovalently associated with a protein called β2-microglobulin
What makes up the peptide-binding cleft of the class I MHC molecule?
Amino-terminal α1 and α2 domains of the α chain
Where are the polymorphic residues of class I MHC molecules located?
α1 and α2 domains of the α chain
What do the polymorphic residues of class I MHC molecules influence?
The ability to bind distinct sets of peptides
Which genes code for the H-2 M and proteasome genes in class 2 MHC locus?
H-2 M and proteasome genes
In which domain do the polymorphic residues of class I MHC molecules contribute to variations?
Floor of the peptide-binding cleft
What part of the class I MHC molecule makes contact with the T cell receptor?
Tops of the cleft walls
What length of peptides can be accommodated by the peptide-binding cleft of class I MHC molecule?
8 to 11 amino acids long
Explore the schematic maps of the human leukocyte antigen (HLA) complex and the mouse H-2 complex to understand the major genes involved in immune responses, including the α and β chains of Class II genes. Learn about the genetic organization of the MHC and its significance in immune function.
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