Podcast
Questions and Answers
Which condition is characterized by generalized activation of the coagulation and fibrinolytic systems?
Which condition is characterized by generalized activation of the coagulation and fibrinolytic systems?
Which type of red blood cell is characterized by a crescent shape and long projections?
Which type of red blood cell is characterized by a crescent shape and long projections?
What is a common association for target cells?
What is a common association for target cells?
Which of the following statements is true regarding MAHA disorders?
Which of the following statements is true regarding MAHA disorders?
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Which test is NOT typically associated with diagnosing DIC?
Which test is NOT typically associated with diagnosing DIC?
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Study Notes
MAHAS
- Group of disorders characterized by RBC fragmentation and thrombocytopenia
- Major types include TTP, HELLP, HUS, and DIC
- Characterized by narrowing/obstruction of small blood vessels by fibrin/platelet aggregates
- Helmet cell is a helmet-shaped schistocyte that can appear in MAHA
Additional information about DIC
- Also known as defibrination syndrome or consumption coagulopathy
- Generalized over-activation of coagulation and fibrinolytic systems
- Not a disease, but a consequence
- Some tests include D-dimer and PF 1+2
- Related conditions: tissue trauma, obstetric complications, mucus-secreting tumors, acute infections (e.g., malaria, Gram-negative septicemia), and acute promyelocytic leukemia
DREPANOCYTE
- Also known as a sickle cell or meniscocyte
- Drepan = sickle
- RBCs
- Two forms of drepanocytes:
- Irreversible Sickle Cell:
- Crescent-shaped
- Long projections
- Fragment upon reoxygenation
- Oat-shaped cell:
- Less pronounced projections
- Return to biconcave disk shape upon reoxygenation
- Irreversible Sickle Cell:
TARGET CELL
- Also known as leptocyte/codocyte
- Platycyte, or Bull's eye cell
- Mexican hat cell or Greek helmet cell
- RBCs with centrally stained area and thin outer rim of hemoglobin
- Related conditions include liver disease, certain hemoglobinopathies (like thalassemia), hereditary leptocytosis, Mediterranean anemia, and LCAT (lecithin cholesterol acyltransferase) deficiency
RELATED INFORMATION
- Codocytes are RBCs with an increased cell membrane-to-volume ratio
- Appear bell-shaped on electron microscopy
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Description
Explore the group of disorders known as MAHAS, characterized by RBC fragmentation and thrombocytopenia. This quiz also delves into DIC, a critical condition linked with coagulation dysfunction, highlighting its causes, related tests, and implications. Test your knowledge on these important hematological topics.
