10 Questions
Which of the following clinical features is NOT associated with hypomagnesemia?
Bradycardia
What is the main treatment approach for hypomagnesemia?
Oral magnesium replacement
Which medication can contribute to the development of hypomagnesemia?
Furosemide
Why do people with kidney disease have a higher risk of magnesium toxicity?
Their kidneys are unable to remove excess magnesium properly
What is a sign of magnesium toxicity according to the text?
Nausea, vomiting
In the body, what is the distribution of magnesium like?
55% in the skeleton, 45% intracellular in soft tissues
What effect does Aldosterone have on plasma magnesium levels?
Decreases plasma magnesium levels by increasing excretion
How does Parathyroid Hormone (PTH) affect plasma magnesium levels?
Mobilizes magnesium from bones to increase plasma levels
What is a major cause of hypermagnesemia according to the text?
Renal failure
What are symptoms associated with hypermagnesemia according to the text?
Hypotension, respiratory depression, cardiac arrest
Study Notes
Hypomagnesemia
- Hypomagnesemia is not associated with alkalosis
- Main treatment approach for hypomagnesemia is magnesium supplementation
- Diuretics, proton pump inhibitors, and aminoglycosides can contribute to the development of hypomagnesemia
Magnesium Toxicity
- People with kidney disease have a higher risk of magnesium toxicity due to impaired excretion
- A sign of magnesium toxicity is cardiac arrest
- In the body, magnesium is primarily distributed in bones (50-60%) and muscles (20-30%)
Hormonal Effects
- Aldosterone increases plasma magnesium levels by decreasing magnesium excretion
- Parathyroid Hormone (PTH) decreases plasma magnesium levels by increasing magnesium excretion
Hypermagnesemia
- A major cause of hypermagnesemia is excessive magnesium intake, especially in individuals with kidney disease
- Symptoms associated with hypermagnesemia include hypotension, respiratory depression, and cardiac arrest
Learn about how magnesium absorption works in the body and how magnesium homeostasis is maintained through the roles of the intestine, bone, and kidneys. Discover the distribution of magnesium in the body and the significance of its storage and excretion processes.
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