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Macrocytic Anemias Overview

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Questions and Answers

What primary factors cause macrocytosis in megaloblastic anemias?

Vitamin B12 or folate deficiency (correct)
Iron deficiency and dehydration
Electrolyte imbalance and liver disease
Chronic inflammation and infection

Which of the following is not considered a drug that can cause macrocytosis?

Zidovudine
Hydroxyurea
Methotrexate
Acetaminophen (correct)

What type of anemia is characterized by macrocytosis due to abnormal DNA metabolism?

Megaloblastic anemia (correct)
Aplastic anemia
Hemolytic anemia
Sideroblastic anemia

Which vitamin deficiency is primarily associated with megaloblastic anemias?

<p>Vitamin B12 (B)</p> Signup and view all the answers

What is the main classification of macrocytic anemias?

<p>Megaloblastic and nonmegaloblastic (C)</p> Signup and view all the answers

Flashcards

Megaloblastic Anemia

A type of anemia characterized by abnormally large red blood cells (macrocytes) due to problems with DNA synthesis.

Macrocytosis

The presence of abnormally large red blood cells (macrocytes) in the blood.

Megaloblastic Anemia: Cause

Anemia caused by a deficiency of vitamin B12 or folate, leading to abnormal DNA synthesis and macrocytosis.

Drug-Induced Macrocytosis

Certain medications can disrupt DNA synthesis causing macrocytosis, resembling megaloblastic anemia.

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Nonmegaloblastic Anemia

A type of macrocytic anemia not related to issues with DNA synthesis, but caused by other factors.

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Study Notes

Macrocytic Anemias

Macrocytic anemias are categorized into megaloblastic and nonmegaloblastic types.
Megaloblastic anemias result in macrocytosis.
Macrocytosis in megaloblastic anemias stems from abnormal DNA metabolism due to vitamin B12 or folate deficiency.
Various drugs can also cause macrocytosis, including hydroxyurea, zidovudine, cytosine arabinoside, methotrexate, azathioprine, 6-mercaptopurine, and cladribine.

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Description

This quiz covers macrocytic anemias, focusing on their classification into megaloblastic and nonmegaloblastic types. Learn about the causes of macrocytosis, specifically the impact of vitamin B12 and folate deficiencies, as well as the influence of various medications. Test your knowledge on this key aspect of hematology.