Podcast
Questions and Answers
What is the primary cause of macrocytosis in megaloblastic anemias?
What is the primary cause of macrocytosis in megaloblastic anemias?
Which vitamin deficiencies are most associated with megaloblastic anemias?
Which vitamin deficiencies are most associated with megaloblastic anemias?
What results from the interference with folic acid- and vitamin B12-interdependent nucleic acid synthesis?
What results from the interference with folic acid- and vitamin B12-interdependent nucleic acid synthesis?
Which of the following drugs can cause macrocytosis?
Which of the following drugs can cause macrocytosis?
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What occurs in erythrocytes during megaloblastosis?
What occurs in erythrocytes during megaloblastosis?
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Study Notes
Macrocytic Anemias
- Macrocytic anemias are classified into megaloblastic and nonmegaloblastic types.
- Megaloblastic anemias arise from abnormal DNA metabolism, often due to vitamin B12 or folate deficiency.
- Certain medications can also cause macrocytosis, including hydroxyurea, zidovudine, cytosine arabinoside, methotrexate, azathioprine, 6-mercaptopurine, and cladribine.
Megaloblastic Anemia
- Megaloblastic anemia is characterized by megaloblastosis.
- Megaloblastosis arises from impaired nucleic acid synthesis (folic acid and vitamin B12) in developing red blood cells (erythrocytes).
- The RNA and cytoplasm production in red blood cells outpaces DNA production.
- This imbalance leads to delayed maturation, resulting in large, immature red blood cells (macrocytosis).
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Description
Dive into the world of macrocytic anemias, focusing on the distinction between megaloblastic and nonmegaloblastic types. Learn about the causes, including vitamin deficiencies and medications that lead to macrocytosis. This quiz will help you understand the pathology and clinical implications of these conditions.
