30 Questions
What diagnostic procedures can be used to render a diagnosis on minimal amounts of material?
Flow cytometry and/or molecular techniques
What is a characteristic of Hodgkin lymphoma?
Proliferation of cells is typically localized to a single group of nodes
In what stage is there lymph node involvement above and below the diaphragm?
Stage III
What is a characteristic of non-Hodgkin lymphomas?
Frequent involvement of multiple groups of nodes
What is the highest stage of lymphoma, characterized by widespread disease?
Stage IV
What is classified as stage III(s) in lymphoma staging?
Involvement of the spleen
What is a common way a patient with lymphoma may initially present?
With an isolated, enlarged superficial lymph node
What is the preferred method for diagnosing lymphoma?
Lymph node biopsy
What may be the first manifestation of a lymphoma?
Organ involvement
What is the importance of biopsying several lymph nodes?
Because the lymphoma may not be distributed evenly in all lymph nodes
What type of lymphoma may become symptomatic when there is cellular proliferation in the orbit?
Non-Hodgkin lymphoma
What may be an initial indicator of the presence of a lymphoma?
Involvement of the bone marrow and peripheral blood
Why may hairy cells be difficult to locate in the bone marrow aspirate?
Because the disorder is often accompanied by fibrosis
What is the characteristic appearance of leukemia cells in hairy cell leukemia?
A shaggy cytoplasmic border
What is the median age for presentation of plasma cell myeloma?
62 years
What is the most frequent presenting symptom of plasma cell myeloma?
Bone pain
What is the name of the condition that may result from the passage of free light chains into the urine?
Myeloma kidney
What is included in the initial workup of myeloma?
Skeletal survey
What is the median age at which CLL predominantly occurs?
70 years
What is the characteristic feature of CLL lymphocytes?
Small size and coarsely clumped chromatin
What is the ratio of male to female patients with CLL?
1.7:1
What is the term used to describe the appearance of CLL lymphocytes on peripheral blood smears?
Smudge cells
What is the significance of a low score of 1 or 2 in CLL diagnosis?
It is consistent with CLL
What has superseded bone marrow biopsies in establishing prognoses in CLL?
Genetic and biologic biomarkers
What is the primary characteristic of Refractory cytopenias with multilineage dysplasia (RCMD)?
Dysplasia in 2 or more lineages
What is the percentage of blasts in the bone marrow in Refractory anemia with excess blasts-1 (RAEB-1)?
5% to 9%
What is the characteristic of Myelodysplastic syndrome, unclassified (MDS-U)?
Dysplasia in 1 lineage other than erythroid
What is the characteristic feature of MDS associated with del(5q)?
Hypolobated megakaryocytes with del(5q)
What is the percentage of WBC blasts in the peripheral blood in RAEB-1?
Less than 5%
What is the characteristic of Refractory anemia with excess blasts-2 (RAEB-2)?
10% to 19% blasts in the bone marrow
Learn about the different types of lymphomas, their symptoms, and how they are classified. Understand the characteristics of Hodgkin lymphoma and non-Hodgkin lymphomas, and how they present in patients.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
