Podcast
Questions and Answers
What is the annual incidence of the disease in the UK?
What is the annual incidence of the disease in the UK?
- 4.7 / 100,000
- 1.7 / 100,000
- 2.7 / 100,000 (correct)
- 3.7 / 100,000
What is the primary purpose of PET-CT in the initial work-up of the disease?
What is the primary purpose of PET-CT in the initial work-up of the disease?
- Detecting bone involvement
- Determining disease staging (correct)
- Assessing liver function
- Identifying histological subtypes
What is required for a favourable prognosis according to GHSG?
What is required for a favourable prognosis according to GHSG?
- Elevated ESR
- Liver dysfunction
- No large mediastinal mass (correct)
- Presence of a large mediastinal mass
What is the primary reason for considering fertility preservation prior to treatment?
What is the primary reason for considering fertility preservation prior to treatment?
What is the purpose of performing a biopsy in the initial work-up of the disease?
What is the purpose of performing a biopsy in the initial work-up of the disease?
Which of the following age groups does not have a peak incidence of the disease?
Which of the following age groups does not have a peak incidence of the disease?
Which of the following tests is not required for staging?
Which of the following tests is not required for staging?
What is the primary difference between the 4 histological subtypes of the disease?
What is the primary difference between the 4 histological subtypes of the disease?
What is the primary reason for performing an HIV test in the initial work-up?
What is the primary reason for performing an HIV test in the initial work-up?
Which of the following laboratory results is not required for the initial work-up?
Which of the following laboratory results is not required for the initial work-up?
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Study Notes
Epidemiology of Hodgkin Lymphoma
- Annual incidence of Hodgkin Lymphoma in the UK is 2.7 per 100,000 people
- Two incidence peaks occur at ages 20-34 and over 70
Initial Work-Up
- Blood tests: FBC, ESR, U&E, LFT, Bone profile, HIV, Hep B, Hep C
- Biopsy is necessary to determine histological subtype
- 4 histological subtypes of Hodgkin Lymphoma: Nodular sclerosis, Mixed cellularity, Lymphocyte-rich, Lymphocyte-depleted
- No difference in outcomes among histological subtypes
Imaging and Staging
- PET-CT is used for staging and detects bone involvement
- BM biopsy is not required
- Fertility preservation should be considered prior to treatment
Staging
- Early stages: Stage I and II
- Favourable prognosis (GHSG) requires:
- No large mediastinal mass
- Normal ESR
Epidemiology of Hodgkin Lymphoma
- Annual incidence of Hodgkin Lymphoma in the UK is 2.7 per 100,000 people
- Two incidence peaks occur at ages 20-34 and over 70
Initial Work-Up
- Blood tests: FBC, ESR, U&E, LFT, Bone profile, HIV, Hep B, Hep C
- Biopsy is necessary to determine histological subtype
- 4 histological subtypes of Hodgkin Lymphoma: Nodular sclerosis, Mixed cellularity, Lymphocyte-rich, Lymphocyte-depleted
- No difference in outcomes among histological subtypes
Imaging and Staging
- PET-CT is used for staging and detects bone involvement
- BM biopsy is not required
- Fertility preservation should be considered prior to treatment
Staging
- Early stages: Stage I and II
- Favourable prognosis (GHSG) requires:
- No large mediastinal mass
- Normal ESR
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