9 Questions
Which infection is associated with the development of gastric lymphoma?
Helicobacter pylori
Which chromosome translocation is associated with dysregulated expression of the BCL-2 gene product in follicular lymphoma?
t(14:18)
In which immunodeficiency state can lymphoma be a late manifestation?
HIV infection
What is the percentage of B-cell origin in Non-Hodgkin lymphoma (NHL)?
70%
What is the median age for Non-Hodgkin lymphoma (NHL) incidence?
65-70 years
Which of the following is NOT a feature of Non-Hodgkin lymphoma?
Associated with Helicobacter pylori infection
What is the main causative abnormality described for lymphomas?
't(14:18)' translocation
What does the t(14:18) translocation do in follicular lymphoma?
Inhibits apoptotic cell death
What is NOT associated with specific chromosome lesions in some lymphomas?
t(9:22) translocation in t(14:18) translocation results in the dysregulated expression of the BCL-2 gene product which inhibits apoptotic cell death
Learn about the challenges in histological classification of Non-Hodgkin's Lymphoma (NHL) and the significance of grade in determining proliferation rate. Explore the WHO classification system based on cell lineage.
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