Lymphoma Classification and Grading

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Questions and Answers

Which infection is associated with the development of gastric lymphoma?

  • Human herpes virus 8 (HHV8)
  • Epstein-Barr virus (EBV)
  • Helicobacter pylori (correct)
  • HTLV infection

Which chromosome translocation is associated with dysregulated expression of the BCL-2 gene product in follicular lymphoma?

  • t(11:14)
  • t(14:18) (correct)
  • t(9:22)
  • t(8:14)

In which immunodeficiency state can lymphoma be a late manifestation?

  • HIV infection (correct)
  • Malaria infection
  • Influenza infection
  • Hepatitis B infection

What is the percentage of B-cell origin in Non-Hodgkin lymphoma (NHL)?

<p>70% (D)</p> Signup and view all the answers

What is the median age for Non-Hodgkin lymphoma (NHL) incidence?

<p>65-70 years (C)</p> Signup and view all the answers

Which of the following is NOT a feature of Non-Hodgkin lymphoma?

<p>Associated with Helicobacter pylori infection (A)</p> Signup and view all the answers

What is the main causative abnormality described for lymphomas?

<p>'t(14:18)' translocation (D)</p> Signup and view all the answers

What does the t(14:18) translocation do in follicular lymphoma?

<p>Inhibits apoptotic cell death (A)</p> Signup and view all the answers

What is NOT associated with specific chromosome lesions in some lymphomas?

<p>t(9:22) translocation in t(14:18) translocation results in the dysregulated expression of the BCL-2 gene product which inhibits apoptotic cell death (B)</p> Signup and view all the answers

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