16 Questions
What is the main characteristic of lymphoma?
It affects the lymphatic system
What are the two main types of lymphoma?
Hodgkin lymphoma and nonHodgkin lymphoma
What are proto-oncogenes responsible for in normal cells?
Regulating cell growth and division
What is the annual incidence of Hodgkin lymphoma in the western world?
3 cases per 100000 person
What is the contagious spread characteristic of Hodgkin lymphoma?
It spreads through the peripheral lymph nodes
What is the key mechanism for cell death mentioned in the text?
Mitochondrial permeability transition-driven necrosis
What is the most common type of Hodgkin lymphoma?
Nodular sclerosis
Which virus is found to infect B-cells and contribute to the pathogenesis of Hodgkin lymphoma?
Epstein-Barr virus (EBV)
What contributes to the conversion of normal B-cells to malignant HRS cells in Hodgkin lymphoma?
Expression of hematopoietic stem cells (HSCs) key transcription factors
What is the key mechanism in the survival of HRS cells in Hodgkin lymphoma?
Ability to secrete different cytokines and chemokines
What percentage of tumors associated with Hodgkin lymphoma is made up of activated normal immune cells?
99%
Which type of lymphoma is characterized by the absence of HRS cells and is considered less common and more dangerous than Hodgkin lymphoma?
B-cell derived non-Hodgkin lymphoma (NHL)
What are the signs and symptoms commonly associated with lymphoma?
Unexplained fever and swollen abdomen
What advanced test can determine if lymphoma cells are present and what types of cells are involved?
Positron emission tomography (PET) scan
In which type of biopsy procedure, all or part of a lymph node is removed for laboratory testing?
Excisional biopsy
What should your doctor check for during a physical exam for diagnosing lymphoma?
Swollen lymph nodes and swollen spleen or liver
This quiz covers the fundamental concepts of lymphoma and immunology, including the mechanisms of cell death, such as apoptosis, necroptosis, and autophagy, as well as an introduction to cancer and proto-oncogenes.
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