10 Questions
Where does the greater part of lymphocyte development in mammals occur?
Bone marrow
How are T-cell numbers maintained in mature individuals?
Through division of mature T cells outside of the central lymphoid organs
What serves as a signal for a cell to progress to the next stage of development during lymphocyte development?
Successful gene rearrangement leading to protein chain production
Which type of T cells have two distinct lineages with different types of T-cell receptor?
α:β
Where are new B cells continually produced, even in adults?
Bone marrow
In lymphocyte development, what specialized environments play a crucial role in providing signals for successful execution of the intrinsic developmental program?
Bone marrow and thymus
What is the significance of the assembly of V, D, and J gene segments in lymphocyte differentiation?
It encodes the antigen-receptor variable (V) region
What defines the different stages of lymphocyte development?
Expression of protein products
Why is not every gene rearrangement event successful in producing a complete in-frame DNA sequence?
Due to imprecision in the recombination process
What is the role of productive rearrangements in lymphocyte development?
They signal progression to the next stage of development
Explore the process of lymphocyte development in mammals, focusing on the specialized environments of the central lymphoid organs such as the bone marrow and thymus. Learn about the migration of new lymphocytes to peripheral lymphoid tissues and the maintenance of T-cell numbers in mature individuals.
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