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10 Questions

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Lymphocyte Development in Mammals

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Questions and Answers

Where does the greater part of lymphocyte development in mammals occur?

Liver

Bone marrow (correct)

Peripheral lymphoid tissues

Thymus

How are T-cell numbers maintained in mature individuals?

Through migration from the bone marrow

By migration to peripheral lymphoid tissues

Through division of mature T cells outside of the central lymphoid organs (correct)

By continuous production in the thymus

What serves as a signal for a cell to progress to the next stage of development during lymphocyte development?

Appearance of functional features

Successful gene rearrangement leading to protein chain production (correct)

T-cell development

Migration to peripheral lymphoid tissues

Which type of T cells have two distinct lineages with different types of T-cell receptor?

α:β Signup and view all the answers

Where are new B cells continually produced, even in adults?

Bone marrow Signup and view all the answers

In lymphocyte development, what specialized environments play a crucial role in providing signals for successful execution of the intrinsic developmental program?

Bone marrow and thymus Signup and view all the answers

What is the significance of the assembly of V, D, and J gene segments in lymphocyte differentiation?

It encodes the antigen-receptor variable (V) region Signup and view all the answers

What defines the different stages of lymphocyte development?

Expression of protein products Signup and view all the answers

Why is not every gene rearrangement event successful in producing a complete in-frame DNA sequence?

Due to imprecision in the recombination process Signup and view all the answers

What is the role of productive rearrangements in lymphocyte development?

They signal progression to the next stage of development Signup and view all the answers