Lung Cancer Screening and Diagnostic Markers Quiz
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Questions and Answers

What is the full form of CAC in the context of the text?

Circulating genetically abnormal cell

What is the abbreviation for computed tomography used in the text?

CT

Which high-risk populations can benefit from screening with LDCT according to the text?

High-risk populations for lung cancer

What is one limitation mentioned in the text regarding CT examination for pulmonary nodules?

<p>CT can't distinguish between benign and malignant nodules</p> Signup and view all the answers

What has emerged as a promising liquid biopsy marker with improved diagnostic performance compared to other markers?

<p>CAC (Circulating genetically abnormal cell)</p> Signup and view all the answers

In which cluster of patients did the AUC of CACs perform better than the overall patients?

<p>Cluster 1</p> Signup and view all the answers

What were the independent risk factors for malignant lung nodules in Cluster 1?

<p>CACs, female, maximum nodule type, and maximum nodule size</p> Signup and view all the answers

What does the diagnostic model for lung nodules use as predictors?

<p>CACs, sex, maximum nodule type, and maximum nodule size</p> Signup and view all the answers

How is the probability of malignancy calculated in the established diagnostic model?

<p>probability of malignancy = 1 / (1 + e^-Y)</p> Signup and view all the answers

What was the AUC value of the diagnostic model for lung nodules?

<p>0.925</p> Signup and view all the answers

At what Youden index value was the optimal cut-off value determined?

<p>0.752</p> Signup and view all the answers

What was the sensitivity of the diagnostic model at the optimal cut-off value?

<p>0.786</p> Signup and view all the answers

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