12 Questions
What is the primary site of action for loop diuretics like Furosemide?
Thick part of the ascending limb of loop of Henle
What is the primary mechanism of action of loop diuretics?
Inhibition of Na+/K+/2Cl- cotransport
What is the primary reason for the high efficacy of loop diuretics?
Large capacity of the loop of Henle to reabsorb NaCl
What is a common side effect of loop diuretics?
Hypokalemia
What is the primary site of action for thiazide diuretics?
Early segment of distal tubules
What is the primary mechanism of action of thiazide diuretics?
Inhibition of Na+/Cl- cotransport
What is the bioavailability of Chlorothiazide when taken orally?
10%
What is the route of administration of nitroglycerine in acute attack of angina pectoris?
Sublingual
What is the mechanism of action of beta adrenergic blockers in preventing angina?
Reduction of heart rate, myocardial contractility and to lesser extent blood pressure
What is the site of action of opioid analgesics in producing analgesia?
Central nervous system
What is the effect of opioid analgesics on the opening of voltage-gated Ca2+ channels?
Decrease in the opening of voltage-gated Ca2+ channels
What is the effect of opioid receptor activation on adenylyl cyclase activity?
Decrease in adenylyl cyclase activity
Learn about loop diuretics, their mechanism of action, and pharmacokinetics. Understand how they work, their site of action, and their effects on sodium and chloride excretion. Test your knowledge on Furosemide (Lasix) and its uses.
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