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Loop Diuretics and Pharmacokinetics

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Questions and Answers

What is the primary site of action for loop diuretics like Furosemide?

Collecting ducts

Early segment of distal tubules

Proximal convoluted tubules

Thick part of the ascending limb of loop of Henle (correct)

What is the primary mechanism of action of loop diuretics?

Inhibition of Na+/K+/2Cl- cotransport (correct)

Inhibition of Ca++/Na+ exchange

Inhibition of K+/Cl- cotransport

Inhibition of Na+/Cl- cotransport

What is the primary reason for the high efficacy of loop diuretics?

Rapid absorption of the drug

Large capacity of proximal convoluted tubules to reabsorb NaCl

High potency of the drug

Large capacity of the loop of Henle to reabsorb NaCl (correct)

What is a common side effect of loop diuretics?

Hypokalemia Signup and view all the answers

What is the primary site of action for thiazide diuretics?

Early segment of distal tubules Signup and view all the answers

What is the primary mechanism of action of thiazide diuretics?

Inhibition of Na+/Cl- cotransport Signup and view all the answers

What is the bioavailability of Chlorothiazide when taken orally?

10% Signup and view all the answers

What is the route of administration of nitroglycerine in acute attack of angina pectoris?

Sublingual Signup and view all the answers

What is the mechanism of action of beta adrenergic blockers in preventing angina?

Reduction of heart rate, myocardial contractility and to lesser extent blood pressure Signup and view all the answers

What is the site of action of opioid analgesics in producing analgesia?

Central nervous system Signup and view all the answers

What is the effect of opioid analgesics on the opening of voltage-gated Ca2+ channels?

Decrease in the opening of voltage-gated Ca2+ channels Signup and view all the answers

What is the effect of opioid receptor activation on adenylyl cyclase activity?

Decrease in adenylyl cyclase activity Signup and view all the answers