Loop Diuretics and Pharmacokinetics

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Questions and Answers

What is the primary site of action for loop diuretics like Furosemide?

  • Collecting ducts
  • Early segment of distal tubules
  • Proximal convoluted tubules
  • Thick part of the ascending limb of loop of Henle (correct)

What is the primary mechanism of action of loop diuretics?

  • Inhibition of Na+/K+/2Cl- cotransport (correct)
  • Inhibition of Ca++/Na+ exchange
  • Inhibition of K+/Cl- cotransport
  • Inhibition of Na+/Cl- cotransport

What is the primary reason for the high efficacy of loop diuretics?

  • Rapid absorption of the drug
  • Large capacity of proximal convoluted tubules to reabsorb NaCl
  • High potency of the drug
  • Large capacity of the loop of Henle to reabsorb NaCl (correct)

What is a common side effect of loop diuretics?

<p>Hypokalemia (A)</p> Signup and view all the answers

What is the primary site of action for thiazide diuretics?

<p>Early segment of distal tubules (C)</p> Signup and view all the answers

What is the primary mechanism of action of thiazide diuretics?

<p>Inhibition of Na+/Cl- cotransport (C)</p> Signup and view all the answers

What is the bioavailability of Chlorothiazide when taken orally?

<p>10% (A)</p> Signup and view all the answers

What is the route of administration of nitroglycerine in acute attack of angina pectoris?

<p>Sublingual (D)</p> Signup and view all the answers

What is the mechanism of action of beta adrenergic blockers in preventing angina?

<p>Reduction of heart rate, myocardial contractility and to lesser extent blood pressure (D)</p> Signup and view all the answers

What is the site of action of opioid analgesics in producing analgesia?

<p>Central nervous system (C)</p> Signup and view all the answers

What is the effect of opioid analgesics on the opening of voltage-gated Ca2+ channels?

<p>Decrease in the opening of voltage-gated Ca2+ channels (C)</p> Signup and view all the answers

What is the effect of opioid receptor activation on adenylyl cyclase activity?

<p>Decrease in adenylyl cyclase activity (C)</p> Signup and view all the answers

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