24 Questions
What is the primary purpose of using diuretics in animals?
To remove extra water volume in animals with edema or volume overload
Which diuretic class inhibits the reabsorption of sodium and chloride in the thick, ascending loop of Henle?
Loop diuretics
What is the potential consequence of combining diuretics from different classes?
Additive and potentially synergistic effects
What is the role of renal vasodilation induced by furosemide?
Dependent on the local synthesis of prostaglandins
What is the duration of diuretic action of furosemide after IV administration?
2 hours
What is the percentage of protein binding for furosemide?
91%–97%
What is the clearance route of furosemide from the body?
Renal tubular secretion
What is the bioavailability of oral furosemide in small animals?
50%
In which patients might higher-than-normal doses of furosemide be required?
Patients with renal disease
What is the major adverse effect from acute administration of large doses of furosemide?
Acute decrease in intravascular volume
Which type of diuretic is torsemide?
Loop diuretic
What happens to the efficacy of furosemide after 14 days of repeated administration?
It decreases
Which diuretics act on the proximal portion of the distal convoluted tubule to inhibit sodium reabsorption?
Thiazide diuretics
Which diuretics decrease the renal excretion of calcium?
Thiazide diuretics
Which drug interaction is a concern when administering furosemide?
NSAIDs
Which potassium-sparing diuretic is most frequently used in veterinary medicine?
Spironolactone
What is the primary function of aldosterone in the renal tubules?
Increase potassium and calcium reabsorption
Why is spironolactone not recommended as monotherapy for heart failure?
It causes hyperkalemia
What is the primary mode of action of carbonic anhydrase inhibitors?
Inhibit the formation of carbonic acid
What is the preferred route of administration for DMSO in large animals?
Intravenous
What is a potential consequence of administering repeated doses of mannitol?
Edema
Which system is activated in response to hyponatremia, hyperkalemia, and decreases in blood pressure or cardiac output?
Renin-angiotensin-aldosterone system (RAAS)
What is the primary function of spironolactone at its receptor site?
Result in mild diuresis and potassium retention
Why should spironolactone not be administered concurrently with potassium supplements?
It causes hyperkalemia
Test your knowledge of diuretics and their classification based on mechanism of action and efficacy. Learn about the different classes of diuretics and their uses in treating edema, ion imbalances, and hypertension.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
