Local Anesthetics Overview

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Questions and Answers

What is the primary reason local anesthetics are effective at numbing an area?

They increase neurotransmitter release.
They enhance blood flow to the area.
They reduce inflammation in the tissue.
They block sodium channels, preventing pain signals. (correct)

Which characteristic of local anesthetics aids in their ability to cross cell membranes?

High water solubility only.
Presence of additives that increase stability.
Chemical structure that repels fats.
Lipid-soluble alkaloids that are lipophilic. (correct)

What is a potential consequence of local anesthetic systemic toxicity?

Improved heart rate stability.
Enhanced cognitive functions.
Interruption of cardiac conduction. (correct)
Decreased excitability of nerve connections.

Which of the following factors may influence the risk of toxicity from local anesthetics?

<p>The lipid solubility of the drug used. (D)</p> Signup and view all the answers

What role does sodium play in the body relevant to local anesthetics?

<p>Contributing to muscle contraction and nerve signal transmission. (D)</p> Signup and view all the answers

Flashcards

What is Local Anaesthetic Systemic Toxicity?

A serious complication that can occur after administering local anesthetic medications.

What makes local anesthetics lipophilic?

Local anesthetics are composed of water-soluble salts and lipid-soluble alkaloids, allowing them to dissolve in both water and fat, making them 'lipophilic'.

How do local anesthetics work?

Local anesthetics block sodium channels, preventing pain signals from reaching the brain.

What is the relationship between lipid solubility and local anesthetic toxicity?

Different local anesthetics have varying abilities to dissolve in lipids. More lipid-soluble anesthetics (like bupivacaine) can cause toxicity faster.

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