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Questions and Answers
What is the primary functional unit of the liver?
What is the primary functional unit of the liver?
The classic hepatic lobule is a circular structure that drains via the portal vein.
The classic hepatic lobule is a circular structure that drains via the portal vein.
False
What surrounds the liver and is made up of a thin CT layer?
What surrounds the liver and is made up of a thin CT layer?
Glisson's capsule
The __________ area contains branches of the portal vein, hepatic artery, and bile duct.
The __________ area contains branches of the portal vein, hepatic artery, and bile duct.
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Match the components of the Space of Disse with their descriptions:
Match the components of the Space of Disse with their descriptions:
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Which type of connective tissue is mentioned as a component of the liver's stroma?
Which type of connective tissue is mentioned as a component of the liver's stroma?
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In humans, the lobulation of the liver is clear due to thick connective tissue septa.
In humans, the lobulation of the liver is clear due to thick connective tissue septa.
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What type of blood vessels are located in the portal area of the classic hepatic lobule?
What type of blood vessels are located in the portal area of the classic hepatic lobule?
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Hepatocytes are arranged in radial cords or __________ radiating from the central vein.
Hepatocytes are arranged in radial cords or __________ radiating from the central vein.
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Which of the following structures is NOT part of the classic hepatic lobule?
Which of the following structures is NOT part of the classic hepatic lobule?
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Study Notes
Liver Histology
- The liver is composed of stroma and parenchyma
- Stroma consists of:
- Capsule (Glisson's capsule): a thin connective tissue layer surrounding the liver.
- Trabeculae: connective tissue septa originating from the capsule, dividing the liver into lobules. Lobulation is clear in animal species (e.g., camel, pig) due to thicker connective tissue septa, but not as clear in humans.
- Reticular connective tissue: forms the background framework of the organ.
- Parenchyma, the functional component, consists of hepatocytes arranged in a well-organized manner in hexagonal lobules
- Hepatocytes (liver cells): the structural and functional units of the liver.
- Arranged in radial cords/plates (1-2 cells thick) radiating from the central vein
- Contained within the hexagonal mass of the hepatic lobule, drained centrally by the central vein
- Located around portal triads at the corners of the lobule
- The portal triad contains:
- Portal vein
- Hepatic artery
- Bile duct
- Lymphatic vessels
- Hepatocytes (liver cells): the structural and functional units of the liver.
- Hepatic lobules: hexagonal units of liver tissue, drained centrally via the central vein. Portal triads are located at the corners of the lobule.
- Bile canaliculi: spaces between hepatocytes where bile is secreted.
- Liver sinusoids: spaces lined by endothelial cells and Kupffer cells, situated between hepatocytes cords.
- Space of Disse: space between endothelial lining of the blood sinusoid and surface of hepatocytes; contains:
- Long microvilli projecting from liver cells
- Ito's cells (stellate cells)
- Fat cells
- Plasma
- Nerve fibers
- Hepatocytes are large cells with a round, pale nucleus and prominent nucleoli. Many are binucleated.
- The cytoplasm of hepatocytes contains numerous mitochondria, abundant rough endoplasmic reticulum (rER) and smooth endoplasmic reticulum (SER), a well-developed Golgi complex, lysosomes, and vacuoles containing various enzymes. Numerous free ribosomes are present.
- Stored glycogen, lipids, and iron are present in hepatocytes.
- The image of the liver with H&E stain displays central vein, sinusoids, and hepatocytes sheets with branches of central vessels (bile duct, hepatic artery , portal veins)
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Description
Explore the intricate structure of the liver's histology, focusing on the stroma and parenchyma. This quiz covers the components such as Glisson's capsule, hepatocytes, and the organization of liver lobules. Perfect for students studying anatomy or histology!
