Podcast
Questions and Answers
What is the end point of progressive damage to the liver?
What is the end point of progressive damage to the liver?
- Accumulation of toxic metabolites
- Destruction of hepatocytes or parenchymal damage (correct)
- Systemic infections, sepsis - renal failure
- Respiratory failure with pneumonia
What is a life-threatening consequence of hepatic failure?
What is a life-threatening consequence of hepatic failure?
- Coagulopathy - bleeding tendency - GIT hemorrhage - bleeding elsewhere (correct)
- Electrolyte disturbances, heart failure
- Liver transplantation
- Chronic liver diseases
In full-blown hepatic failure, what percentage of patients may recover spontaneously?
In full-blown hepatic failure, what percentage of patients may recover spontaneously?
- 30%
- 0% (correct)
- 10%
- 20%
What is the treatment for acute or chronic liver failure?
What is the treatment for acute or chronic liver failure?
Which category of liver failure involves massive hepatic necrosis?
Which category of liver failure involves massive hepatic necrosis?
Primary liver diseases are caused by heart failure, diabetes, and extrahepatic infections.
Primary liver diseases are caused by heart failure, diabetes, and extrahepatic infections.
Hepatic failure results in the loss of 70% to 80% of hepatic function.
Hepatic failure results in the loss of 70% to 80% of hepatic function.
Full-blown hepatic failure leads to death in 80% of patients within weeks to a few months.
Full-blown hepatic failure leads to death in 80% of patients within weeks to a few months.
Acute liver failure is the most common category of liver failure.
Acute liver failure is the most common category of liver failure.
Liver transplantation is not a treatment option for acute or chronic liver failure.
Liver transplantation is not a treatment option for acute or chronic liver failure.
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Study Notes
Liver Diseases Overview
- The human liver weighs around 1500g and makes up about 2% of total body weight, located under the diaphragm on the right side of the abdomen.
- The liver plays a crucial role in maintaining metabolic homeostasis, including albumin and bile production, blood filtration, amino acid regulation, blood clotting, resistance to infections, vitamin and mineral storage, and glucose processing.
- Surgical removal of 60% of the liver in a normal person results in minimal and transient hepatic impairment, with most of its mass restored through regeneration within 4 to 6 weeks.
- The liver is vulnerable to a wide range of metabolic, toxic, microbial, and circulatory insults, leading to various liver diseases, including primary and secondary diseases related to heart failure, diabetes, and extrahepatic infections.
- Hepatic failure is the end point of progressive liver damage, resulting in the destruction of hepatocytes or parenchymal damage and the loss of 80% to 90% of hepatic function.
- Hepatic failure is life-threatening due to the accumulation of toxic metabolites, respiratory failure, coagulopathy, systemic infections, sepsis, renal failure, and electrolyte disturbances.
- Full-blown hepatic failure leads to 80% death within weeks to a few months, while 40% of patients with acute liver failure may recover spontaneously.
- Liver transplantation is a treatment option in acute or chronic liver failure, which can be categorized into acute liver failure with massive hepatic necrosis, chronic liver diseases, and hepatocellular carcinoma.
- Liver diseases are a significant focus in the Department of Biomedical Sciences' Systemic Pathology course, with course code 3401203, offered in Semester 1 of Year 3 for Batch 22 students, taught by Nada Suliman, BDS, MPH, PHD, with a class date of 14/11/2023 at 1445AH.
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