18 Questions
Which type of obstruction is associated with elevated B2 levels and elevated ALP & B2?
Extrahepatic Biliary Obstruction
In which condition is AST greater than ALT, and ALP is very high?
Laennec’s cirrhosis
Which disease is specifically associated with Anti Mitochondrial Ab (AMA) and attacks the biliary tract?
Biliary cirrhosis
Which condition results in high lipase & amylase levels in liver function tests?
Pancreatitis
In which condition is ALT greater than AST and declines with steroids?
Chronic Active Hepatitis
Which condition leads to a decrease in synthetic function and portal hypertension?
Laennec’s cirrhosis
Why does the ALT level have minimal increase during Chronic Hep C?
Because ALTs are confined inside the vacuoles of the cells and there is no leakage of cell components
What condition can lead to minimal increase in ALT levels in the liver?
Fatty liver
Which liver condition is characterized by normal AST & ALT levels and fibrosis instead of necrosis?
Cirrhosis
In which situation is ALT considered to be a good marker for liver cell necrosis?
Toxic/Ischemic injury
What is a distinguishing feature of liver function tests in Severe Alcoholic Hepatitis?
Elevated AST levels higher than ALT levels
What is a common cause of elevated transaminases in asymptomatic patients with no jaundice?
Iron, Cu, or A1AT deficiency
What scenario stimulates an immediate increase in AST and ALT levels in liver function tests?
Acute hepatitis causing immediate elevation in enzyme levels
Which condition is associated with normal AST & ALT levels and apoptosis rather than necrosis?
Chronic Hepatitis C
What does a De Ritis Ratio value of 2, 4, 5 indicate in liver function tests?
Alcoholic hepatitis or other conditions with elevated AST compared to ALT
What happens to the production of transaminases as the liver becomes more fibrotic?
Decreases
Why do ALT levels remain relatively stable in Chronic Hepatitis C compared to necrosis?
'Peklat' helps keep ALT confined inside the cell vacuoles
In which group of patients would you expect ALT values to not conform to the normal reference range?
Renal dialysis patients
Learn about Chronic Active Hepatitis, Extrahepatic Biliary Obstruction, Intrahepatic Biliary Obstruction, and Reye's Syndrome including their characteristics and diagnostic features.
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