Podcast
Questions and Answers
Which of the following is NOT a cause of cirrhosis?
Which of the following is NOT a cause of cirrhosis?
- Hepatitis C virus (HCV)
- Autoimmune hepatitis
- Nonalcoholic fatty liver disease (correct)
- Hepatitis B virus (HBV)
What is the primary pathological feature of cirrhosis?
What is the primary pathological feature of cirrhosis?
- Necrosis of liver cells
- Fibrosis and nodule formation (correct)
- Impairment of liver cell function
- Portal vein hypertension
Which of the following is NOT a clinical feature of cirrhosis?
Which of the following is NOT a clinical feature of cirrhosis?
- Loss of body hair
- Jaundice
- Hepatomegaly (enlarged liver) (correct)
- Fever
What is the difference between compensated and decompensated cirrhosis?
What is the difference between compensated and decompensated cirrhosis?
Which of the following is a complication of cirrhosis?
Which of the following is a complication of cirrhosis?
What is the primary reason for the gross distortion of liver architecture in cirrhosis?
What is the primary reason for the gross distortion of liver architecture in cirrhosis?
What is the most common malignant liver tumor known for its association with viral hepatitis?
What is the most common malignant liver tumor known for its association with viral hepatitis?
Which feature is characteristic of a well-differentiated hepatocellular carcinoma?
Which feature is characteristic of a well-differentiated hepatocellular carcinoma?
How is hepatocellular carcinoma typically diagnosed in patients with cirrhosis and asymptomatic presentation?
How is hepatocellular carcinoma typically diagnosed in patients with cirrhosis and asymptomatic presentation?
What is the management approach for hepatocellular carcinoma in patients with a liver mass larger than 2cm and cirrhosis?
What is the management approach for hepatocellular carcinoma in patients with a liver mass larger than 2cm and cirrhosis?
Which liver disease is characterized by clinical features such as weight loss, fever, anorexia, ascites, and abdominal pain?
Which liver disease is characterized by clinical features such as weight loss, fever, anorexia, ascites, and abdominal pain?
Which demographic group is more commonly affected by alcoholic liver disease in the West?
Which demographic group is more commonly affected by alcoholic liver disease in the West?
What is the most common biopsy finding in alcoholic individuals?
What is the most common biopsy finding in alcoholic individuals?
Which of the following is NOT a characteristic feature of alcoholic hepatitis?
Which of the following is NOT a characteristic feature of alcoholic hepatitis?
Which of the following statements about alcoholic cirrhosis is NOT correct?
Which of the following statements about alcoholic cirrhosis is NOT correct?
Which of the following is NOT a common complication associated with cirrhosis?
Which of the following is NOT a common complication associated with cirrhosis?
In the context of alcoholic liver disease, what is the function of Mallory bodies?
In the context of alcoholic liver disease, what is the function of Mallory bodies?
Which of the following statements about the treatment of alcoholic hepatitis is correct?
Which of the following statements about the treatment of alcoholic hepatitis is correct?
Cirrhosis is always reversible with proper treatment.
Cirrhosis is always reversible with proper treatment.
The primary cause of cirrhosis in the West is viral infections.
The primary cause of cirrhosis in the West is viral infections.
Cirrhosis can lead to portal vein hypertension.
Cirrhosis can lead to portal vein hypertension.
Compensated cirrhosis is associated with severe liver dysfunction and complications.
Compensated cirrhosis is associated with severe liver dysfunction and complications.
Spider angioma is not a clinical feature of cirrhosis.
Spider angioma is not a clinical feature of cirrhosis.
Alcoholic liver disease does not include non-alcohol fatty liver disease as a cause.
Alcoholic liver disease does not include non-alcohol fatty liver disease as a cause.
Alcoholic cirrhosis is always symptomatic and presents with clear signs of chronic liver disease.
Alcoholic cirrhosis is always symptomatic and presents with clear signs of chronic liver disease.
Cirrhotic liver is characterized by a smooth external surface without any regenerating nodules.
Cirrhotic liver is characterized by a smooth external surface without any regenerating nodules.
The primary management approach for cirrhosis is aimed at treating the underlying cause of the disease.
The primary management approach for cirrhosis is aimed at treating the underlying cause of the disease.
Alcoholic fatty liver is usually associated with significant symptoms and abnormal lab tests.
Alcoholic fatty liver is usually associated with significant symptoms and abnormal lab tests.
The microscopic hallmark of alcoholic hepatitis is the presence of Mallory bodies in hepatocytes surrounded by fibrous tissue.
The microscopic hallmark of alcoholic hepatitis is the presence of Mallory bodies in hepatocytes surrounded by fibrous tissue.
Abstinence from alcohol can significantly improve the 5-year survival rate in patients with cirrhosis.
Abstinence from alcohol can significantly improve the 5-year survival rate in patients with cirrhosis.
Hepatocellular carcinoma (HCC) is the most common benign liver tumour.
Hepatocellular carcinoma (HCC) is the most common benign liver tumour.
Primary liver tumors can only be malignant and never benign.
Primary liver tumors can only be malignant and never benign.
Cirrhosis is not a risk factor for developing Hepatocellular carcinoma (HCC).
Cirrhosis is not a risk factor for developing Hepatocellular carcinoma (HCC).
Contraceptive pills have a strong association with the development of Hepatocellular carcinoma (HCC).
Contraceptive pills have a strong association with the development of Hepatocellular carcinoma (HCC).
Liver cells in well-differentiated liver tumors show features of normal hepatocytes.
Liver cells in well-differentiated liver tumors show features of normal hepatocytes.
Chemoembolization is often the most effective treatment for Hepatocellular carcinoma (HCC).
Chemoembolization is often the most effective treatment for Hepatocellular carcinoma (HCC).
Study Notes
- Liver tumours can be either benign or malignant, with hepatocellular carcinoma (HCC) being the most common malignant liver tumour.
- HCC is associated with risk factors such as cirrhosis, particularly due to viral hepatitis, as well as HBV and HCV carriers who are at extremely high risk of developing HCC.
- The pathology of HCC involves a stepwise progression from cirrhosis to dysplastic nodules to tumours, with histological features including liver cell cords lined by endothelial cells.
- Clinical features of HCC include weight loss, fever, anorexia, ascites, and abdominal pain, with rapid development of these features in cirrhosis patients likely indicating HCC.
- Diagnostic investigations for HCC include serum AFP levels, ultrasound or CT scanning, MRI or angiography, and biopsy in cases of diagnostic doubt.
- Management options for HCC may include surgical resection or liver transplantation, with chemoembolisation considered for selected patients while chemotherapy and radiotherapy are generally unhelpful.
- Alcoholic liver disease is the most common cause of chronic liver disease in the West, with major pathological lesions including alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis.
- Alcoholic fatty liver is characterized by fat accumulation in hepatocytes due to alcohol consumption, often presenting with hepatomegaly and elevated MCV, with fat disappearing upon alcohol cessation but continued drinking leading to fibrosis and cirrhosis.
- Alcoholic hepatitis is characterized by liver cell necrosis and inflammation, with varying presentations from asymptomatic to severe hepatic failure, and treatment may involve corticosteroids in severe cases.
- Alcoholic cirrhosis is the final stage of liver disease from alcohol abuse, with destruction and fibrosis leading to micronodular cirrhosis, and management focuses on addressing complications of cirrhosis and advising lifelong abstinence from alcohol.
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Description
Test your knowledge on cirrhosis, liver tumour, and alcoholic liver disease. Learn about the pathogenesis, pathology, and outcomes associated with these liver conditions.
