Liver and Bile Duct Disorders
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Questions and Answers

What is a common cause of large bile duct obstruction?

  • Cholangiopathies
  • Gallstones and head of the pancreas malignancies (correct)
  • Neonatal hepatitis
  • Autoimmune disease

What is primary biliary cholangitis characterized by?

  • Progressive inflammatory and sclerosing destruction of intrahepatic and extrahepatic bile ducts
  • Impaired blood inflow and defects in intrahepatic blood flow
  • Autoimmune disease with progressive, inflammatory, granulomatous destruction of small to medium intrahepatic bile ducts (correct)
  • Progressive inflammatory destruction of small to medium intrahepatic and extrahepatic bile ducts

What is the most common cause of impaired intrahepatic blood flow?

  • Portal vein thrombosis
  • Cirrhosis (correct)
  • Sinusoidal obstruction syndrome
  • Hepatic vein thrombosis

What is a complication of portal vein obstruction?

<p>Portal hypertension, esophageal varices, and ascites (B)</p> Signup and view all the answers

What is the term for a benign tumor of hepatocytes?

<p>Hepatocellular adenoma (A)</p> Signup and view all the answers

Which of the following is a common site of metastatic cancers?

<p>Liver (A)</p> Signup and view all the answers

What is the primary cause of postrenal azotemia?

<p>Urine flow obstruction (D)</p> Signup and view all the answers

What is the term for the daily protein loss in the urine of 3.5g and more?

<p>Proteinuria (B)</p> Signup and view all the answers

What is the most common form of glomerulonephritis caused by the formation of immune complexes?

<p>Granular pattern of deposition (C)</p> Signup and view all the answers

What is the term for the elevation of blood urea nitrogen and creatinine levels?

<p>Azotemia (B)</p> Signup and view all the answers

What is the term for the derangement in capillary walls of the glomeruli that results in increased permeability to plasma proteins?

<p>Nephrotic syndrome (A)</p> Signup and view all the answers

What is the term for the clinical manifestations that arise from azotemia?

<p>Uremia (A)</p> Signup and view all the answers

What is the main cause of Acute Kidney Injury?

<p>Acute Tubular Injury (D)</p> Signup and view all the answers

What is the result of loss-of-function mutations in the metal ion transporter ATP7B?

<p>Copper accumulation in the liver, brain, and eyes (C)</p> Signup and view all the answers

What is the result of obstruction of the flow of bile?

<p>Jaundice and bile pigment accumulation in parenchyma (D)</p> Signup and view all the answers

What is characterized by scarring of the pelvicalyceal system and the kidney interstitium?

<p>Chronic Pyelonephritis (C)</p> Signup and view all the answers

What is caused by an IgE- or T cell–mediated immune reaction to a drug?

<p>Drug-induced interstitial nephritis (C)</p> Signup and view all the answers

What is the result of mutation in α1AT?

<p>Alpha 1 anti-trypsin deficiency (C)</p> Signup and view all the answers

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