Podcast
Questions and Answers
What is the primary reason why Hepatitis C virus cannot integrate into our genome?
What is the primary reason why Hepatitis C virus cannot integrate into our genome?
- It is a DNA virus
- It lacks the necessary enzymes for integration
- It replicates extracellularly only
- It has a single strand of RNA (correct)
Which component of the Hepatitis C virus is cleaved to form structural components like core and envelope proteins?
Which component of the Hepatitis C virus is cleaved to form structural components like core and envelope proteins?
- Amino acid protein chain (correct)
- RNA genome
- Viral envelope
- Non-structural proteins
What is the significance of genotypes in Hepatitis C virology?
What is the significance of genotypes in Hepatitis C virology?
- They determine the host immune response
- They affect the rate of viral replication
- They influence the choice of antiviral therapy (correct)
- They determine viral shedding duration
What symptoms might an individual with acute HCV infection present with?
What symptoms might an individual with acute HCV infection present with?
At approximately what time after exposure to HCV do liver enzyme elevations typically occur?
At approximately what time after exposure to HCV do liver enzyme elevations typically occur?
What percentage of patients exposed to HCV develop chronic infection?
What percentage of patients exposed to HCV develop chronic infection?
How many years of infection does it take for about 16-20% of individuals with chronic HCV infection to develop cirrhosis?
How many years of infection does it take for about 16-20% of individuals with chronic HCV infection to develop cirrhosis?
What is the average yearly risk of hepatic decompensation after cirrhosis in patients with HCV infection?
What is the average yearly risk of hepatic decompensation after cirrhosis in patients with HCV infection?
In which geographic area do genotypes 1a and 1b predominate according to common subtype testing?
In which geographic area do genotypes 1a and 1b predominate according to common subtype testing?
Which diagnostic test is used as a marker of immune response to the hepatitis B virus?
Which diagnostic test is used as a marker of immune response to the hepatitis B virus?
What does the presence of HBV e Antigen indicate in a patient?
What does the presence of HBV e Antigen indicate in a patient?
What does a high HBV DNA viral load indicate?
What does a high HBV DNA viral load indicate?
In individuals undergoing immune suppression, what may put them at risk for rapid progression of liver disease?
In individuals undergoing immune suppression, what may put them at risk for rapid progression of liver disease?
Which antibody is typically seen in the recovery phase of natural hepatitis B infection?
Which antibody is typically seen in the recovery phase of natural hepatitis B infection?
What does the presence of Core IgM suggest in terms of hepatitis B infection?
What does the presence of Core IgM suggest in terms of hepatitis B infection?
Which test is used to monitor the state of hepatitis B infection and determine the need for therapy based on liver enzyme levels?
Which test is used to monitor the state of hepatitis B infection and determine the need for therapy based on liver enzyme levels?
"Not everyone living with HBV requires therapy immediately" - Which criteria are typically used to determine the need for immediate therapy in HBV patients?
"Not everyone living with HBV requires therapy immediately" - Which criteria are typically used to determine the need for immediate therapy in HBV patients?
In adults, what percentage may have symptomatic acute infection?
In adults, what percentage may have symptomatic acute infection?
What does HBV Surface Antigen (HBS Ag) signify?
What does HBV Surface Antigen (HBS Ag) signify?
What is the percentage of individuals exposed to HCV who will develop antibodies by 6 months after exposure?
What is the percentage of individuals exposed to HCV who will develop antibodies by 6 months after exposure?
Which group of individuals may experience false negatives in HCV antibody testing?
Which group of individuals may experience false negatives in HCV antibody testing?
What is the lower limit of quantification for detecting the HCV virus using RNA PCR?
What is the lower limit of quantification for detecting the HCV virus using RNA PCR?
Which test should be ordered for individuals with detectable HCV RNA?
Which test should be ordered for individuals with detectable HCV RNA?
What does SVR stand for in the context of HCV therapy?
What does SVR stand for in the context of HCV therapy?
Which factor is NOT considered when determining eligibility for HCV therapy?
Which factor is NOT considered when determining eligibility for HCV therapy?
What does APRI > 2 indicate in terms of liver disease?
What does APRI > 2 indicate in terms of liver disease?
Which class of DAA agents targets the NS5B polymerase?
Which class of DAA agents targets the NS5B polymerase?
'Hepatitis B can form a minichromosome within the nucleus' - Which structure enables this process?
'Hepatitis B can form a minichromosome within the nucleus' - Which structure enables this process?
What is the goal of HBV therapy?
What is the goal of HBV therapy?
Which of the following is a first-line therapy for HBV due to its high potency?
Which of the following is a first-line therapy for HBV due to its high potency?
What percentage of individuals develop resistance to Lamivudine by 5 years of treatment?
What percentage of individuals develop resistance to Lamivudine by 5 years of treatment?
Which HBV therapy can overcome some Lamivudine resistance?
Which HBV therapy can overcome some Lamivudine resistance?
How is the success of antiviral therapy in HBV treatment typically monitored?
How is the success of antiviral therapy in HBV treatment typically monitored?
Which viral marker indicates seroconversion in HBV treatment?
Which viral marker indicates seroconversion in HBV treatment?
What is the mainstay for global HBV prevention?
What is the mainstay for global HBV prevention?
In which vaccine is synthetic hepatitis B surface antigen used?
In which vaccine is synthetic hepatitis B surface antigen used?
'Immunity defined as HBSAb titre > 10 IU/mL' implies what regarding HBV vaccination?
'Immunity defined as HBSAb titre > 10 IU/mL' implies what regarding HBV vaccination?
'Those with immune compromise may need higher dose vaccine or more frequent dosing.' This statement applies to individuals with which conditions?
'Those with immune compromise may need higher dose vaccine or more frequent dosing.' This statement applies to individuals with which conditions?
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