Liver Anatomy and Lobes

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Questions and Answers

Which ligament separates the left and caudate lobes of the liver?

  • Ligamentum Venosum (correct)
  • Falciform Ligament
  • Coronary Ligament
  • Ligamentum Teres

What structure is found within the Falciform Ligament?

  • Ligamentum Teres (correct)
  • Hepatic Artery
  • Ligamentum Venosum
  • Portal Vein

Which fissure separates the right lobe into anterior and posterior segments?

  • Main Lobar Fissure
  • Left Intersegmental Fissure
  • Right Intersegmental Fissure (correct)
  • None of the above

Which lobe of the liver is the largest?

<p>Right Lobe (A)</p> Signup and view all the answers

What is the function of the Glisson capsule?

<p>To cover the liver and provide support (D)</p> Signup and view all the answers

Which structure connects the lesser curvature of the stomach to the liver?

<p>Gastrohepatic Ligament (B)</p> Signup and view all the answers

Which of the following is a remnant of the ductus venosum from fetal life?

<p>Ligamentum Venosum (A)</p> Signup and view all the answers

What is the name of the space that the main lobar fissure passes through?

<p>Both A and C (D)</p> Signup and view all the answers

Which of the following statements about hepatic veins is true?

<p>Hepatic veins have a small amount of collagen in their walls. (D)</p> Signup and view all the answers

What percentage of the liver's blood supply comes from the hepatic artery?

<p>30% (C)</p> Signup and view all the answers

In portal venous hypertension, what pressure measurement indicates it is hemodynamically significant?

<p>Hepatic venous gradient &gt;5 mm Hg (A), Portal venous pressure &gt;10 mm Hg (B)</p> Signup and view all the answers

Which structure is responsible for 70% of the liver's blood supply?

<p>Portal veins (D)</p> Signup and view all the answers

What is a secondary cause of portal vein thrombosis?

<p>Cirrhosis (D)</p> Signup and view all the answers

Which space is located anterior to the right kidney and lateral to the right lobe of the liver?

<p>Morison pouch (D)</p> Signup and view all the answers

What is the primary function of the portal veins with respect to blood circulation in the liver?

<p>Carry blood from the bowel to the liver (B)</p> Signup and view all the answers

Which segment of the liver is known as the caudate lobe?

<p>Segment I (A)</p> Signup and view all the answers

Which structure separates the anterior segment of the right lobe from the medial segment of the left lobe?

<p>Main lobar fissure (B)</p> Signup and view all the answers

What is the appearance of the liver structures described as echogenic or hyperechoic indicative of?

<p>Presence of collagen and fat (A)</p> Signup and view all the answers

Which ligament is known to form the most caudal division of the left lobe of the liver?

<p>Ligamentum teres (C)</p> Signup and view all the answers

Which of the following statements about the hepatic arteries is correct?

<p>They supply oxygenated blood to the liver (D)</p> Signup and view all the answers

Which of the following spaces is located between the superior border of the liver and the diaphragm?

<p>Subphrenic space (B)</p> Signup and view all the answers

What is the primary purpose of a Transjugular Intrahepatic Portosystemic Shunt (TIPS)?

<p>To alleviate symptoms from portal hypertension (A)</p> Signup and view all the answers

Which type of liver abscess is most likely associated with travel abroad and ingesting contaminated water?

<p>Ambeic abscess (A)</p> Signup and view all the answers

What appearance is characteristic of a candidiasis infection in the liver?

<p>Bullseye appearance (D)</p> Signup and view all the answers

Which type of hepatitis is primarily spread by the fecal-oral route?

<p>Hepatitis A (B)</p> Signup and view all the answers

What is a common risk factor for fatty infiltration of the liver?

<p>Obesity (D)</p> Signup and view all the answers

Which imaging appearance is associated with chronic hepatitis?

<p>Decreased brightness of portal triads (A)</p> Signup and view all the answers

What term describes the inflammatory and infectious disease of the liver, encompassing several types?

<p>Hepatitis (D)</p> Signup and view all the answers

What ultrasound finding may suggest cirrhosis?

<p>Coarse liver texture (B)</p> Signup and view all the answers

Which benign liver condition is described as a tumor of the glandular epithelium that is more common in women?

<p>Adenoma (A)</p> Signup and view all the answers

What symptom is common among patients with schistosomiasis affecting the liver?

<p>Leukocytosis (C)</p> Signup and view all the answers

In the context of liver pathology, what does the term 'micronodular cirrhosis' denote?

<p>Uniformly small nodules (B)</p> Signup and view all the answers

Which of the following is NOT a likely cause of pyogenic liver abscess?

<p>Chronic alcoholism (A)</p> Signup and view all the answers

What is the echogenicity pattern often seen in a hepatic adenoma?

<p>Hyperechoic with a central hypoechoic area (B)</p> Signup and view all the answers

Which parasitic infection is particularly linked to traveling to underdeveloped countries and presents with distinctive cystic masses?

<p>Echinococcal cyst (D)</p> Signup and view all the answers

Flashcards

What is the liver?

The largest solid organ in the human body, weighing approximately 1600g in males and 1400g in females.

What is the Glisson's capsule?

A thin, fibrous capsule that surrounds the liver, providing structural support and protecting it.

How many lobes does the liver have?

The liver is divided into three main lobes: the left, right, and caudate lobes.

What are the ligaments of the liver?

These are fibrous bands that connect the liver to surrounding structures, providing support and helping anchor it in place.

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What are the fissures of the liver?

These are deep grooves or indentations in the surface of the liver, often housing blood vessels, bile ducts, or other structures.

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Why is the liver considered a vascular organ?

The liver is a highly vascular organ, meaning it's rich in blood vessels. These vessels carry blood to and from the liver.

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What is the biliary tract?

A network of tubes that carries bile, a fluid produced by the liver that aids in digestion, to the gallbladder and then to the small intestine.

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How is the left lobe of the liver divided?

The left lobe of the liver is further subdivided into medial and lateral segments by the left hepatic vein and ligamentum teres, a remnant of the fetal umbilical vein.

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Morison's Pouch

A space located lateral to the right lobe of the liver, anterior to the right kidney, and communicating with the right paracolic space.

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Subhepatic space

Space located between the inferior edge of the right lobe of the liver and the right kidney.

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Subphrenic space

Area between the superior border of the liver and the diaphragm.

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Segment I (Caudate lobe)

The left lobe of the liver, situated posteriorly and superiorly, is known for its unique shape and location.

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Segments II and III (Left Superior and Inferior Lateral Segments)

These segments represent the upper portions of the left lobe and are further divided into superior and inferior lateral sections.

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Segments IVa and IVb (Medial Segments of the Left Lobe)

These segments represent the central part of the left lobe.

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Segments V and VI (Caudal to the Transverse Plane)

These segments are located below the transverse plane of the liver.

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Segments VII and VIII (Cephalad to the Transverse Plane)

These segments are positioned above the transverse plane of the liver.

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What are the hepatic veins?

The hepatic veins are responsible for draining deoxygenated blood from the liver directly into the inferior vena cava (IVC).

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How does the blood flow in the hepatic veins look on Doppler?

The hepatic vein waveform is triphasic, reflecting the pressure changes in the right atrium of the heart. It shows two antegrade waves (diastolic and systolic) and a smaller retrograde wave during atrial contraction (atrial kick).

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What is the role of the hepatic artery in the liver?

The proper hepatic artery enters the liver at the porta hepatis, branching into right, middle, and left hepatic arteries. It provides approximately 30% of the liver's blood supply, carrying oxygenated blood to the liver.

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What is the main function of the portal vein?

The portal vein carries nutrient-rich blood from the digestive system to the liver. It branches into right and left portal veins at the porta hepatis, supplying 70% of the liver’s blood volume. It is characterized by its fibrin-containing walls.

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What is portal venous hypertension?

Portal venous hypertension is a condition where the pressure in the portal vein system is elevated, usually above 10mmHg. It is often caused by liver disease or obstruction of the portal vein. It manifests with ascites, splenomegaly, and bleeding from varices.

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What is TIPS?

A procedure where a stent graft is placed between a hepatic vein and the portal vein to alleviate symptoms from portal hypertension. Effectively bypassing the liver, it redirects portal venous flow to the IVC via the hepatic vein, often from the right portal vein to the right hepatic vein.

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What are some causes of liver inflammation/infection?

Liver inflammation or infection. It can be caused by various factors such as abscesses, candidiasis, echinococcal cysts, hepatitis, and schistosomiasis.

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What are the characteristics of Liver Abscesses?

Occur in both ambeic and pyogenic forms. Symptoms include fever, chills, hepatomegaly, elevated Alk Phos, jaundice, abdominal pain. Often linked to travel abroad and linked to contamination of water or food.

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What is Candidiasis?

Caused by the Candida species, commonly in immunocompromised individuals. Multiples small, hypoechoic masses appear on ultrasound with echogenic central cores, making a "wheel with a wheel" or "bullseye" appearance.

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What is an Echinococcal cyst?

Infections from parasitic tapeworms. Often found in people with a history of traveling to underdeveloped countries. Two different appearances on ultrasounds: septated cystic mass or collapsed cyst within a cyst.

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What is Hepatitis?

A general category of inflammatory and infectious disease of the liver. Types include A, B, and C, with symptoms like fever, fatigue, pain in the upper right area of your abdomen, joint pain, nausea or vomiting, diarrhea, loss of appetite, jaundice, dark urine, and pale/clay-colored stool.

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How is Hepatitis A spread?

Spread by fecal contamination, often through an infective person's stool. A vaccine is available if given within two weeks of exposure.

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How is Hepatitis B spread?

Spread via blood and other bodily fluids or contaminated needles. A vaccine is given in infancy, with treatment available with antiviral drugs for the 800,000 people in the US living with chronic Hep B.

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How is Hepatitis C spread?

Spread through blood and bodily fluids via contaminated needles. Afflicts 2.4 million people, with treatment via antiviral drugs.

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What is Fatty Infiltration?

An acquired disorder causing the accumulation of triglycerides (lipids) within hepatocytes. It is often reversible and associated with risk factors like obesity, alcohol abuse, hyperlipidemia, diabetes, hepatitis, metabolic disorder, ulcerative colitis.

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What is Cirrhosis?

A chronic degenerative disease resulting in disorganization of the liver's lobular architecture. Lobes are covered with fibrous tissue, parenchyma degenerates, and lobules are infiltrated with fat. Alcoholism, biliary obstruction, hepatitis, Budd-Chaiari syndrome, nutrient deficiency, and cardiac disease are common causes.

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What is a Hepatic Adenoma?

A tumor of glandular epithelium, more common in women, often related to oral contraceptive use. It is often asymptomatic or causes right upper quadrant pain. Increased incidence is often related to type I glycogen storage disease or von Gierke disease.

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What is Focal Nodular Hyperplasia?

The second most common benign liver mass (after hemangiomas). It is often asymptomatic, but can cause right upper quadrant pain. It can be hyperechoic, hypoechoic, isoechoic, or mixed on ultrasound, often displaying a central hypoechoic area due to hemorrhage.

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What is Schistosomiasis?

An infectious parasite that travels to the lungs and then the liver, causing increased echogenicity of the portal walls, atrophy in the right and left lobes of the liver, thickened gallbladder walls, and portosystemic collaterals.

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Study Notes

Liver Anatomy

  • The liver is the largest solid organ in the body
  • It weighs 1600g in males and 1400g in females
  • Covered by Glisson capsule
  • 3 lobes (left, right, and caudate)
  • Ligaments, fissures, and spaces
  • Vascular (hepatic arteries, hepatic veins, portal veins)
  • Biliary Tract

Lobes of the Liver

  • Left lobe is divided into medial and lateral segments by the left hepatic vein and ligamentum teres
  • Separated from the caudate lobe by the ligamentum venosum
  • Separated from the right lobe by the middle hepatic vein superiorly and the main lobar fissure inferiorly
  • Right lobe is divided into anterior and posterior segments by the right hepatic vein
  • 6x's larger than the left lobe
  • Three posterior fossae (gallbladder, porta hepatis, IVC)
  • Caudate lobe is the smallest lobe of the liver
  • Separated from the left lobe by the ligamentum venosum

Ligaments of the Liver

  • The liver is attached to the diaphragm, anterior abdominal wall, stomach and retroperitoneum by ligaments
  • Coronary ligament connects the liver to the body wall (upper and lower layers)
  • Falciform ligament connects the liver to the anterior abdominal wall and extends from the diaphragm to the umbilics. Separates the right and left subphrenic spaces
  • Gastrohepatic ligament attaches the lesser curvature of the stomach to the liver
  • Hepatoduodenal ligament connects the liver to the proximal duodenum
  • Ligamentum Teres (round ligament) lies within the falciform ligament
  • Previous fetal umbilical vein
  • Triangular ligament is the most lateral portion of the coronary ligament and connects the liver to the body wall
  • Ligamentum Venosum separates the left lobe from the caudate lobe and is the obliterated ductus venosum (fetal life)
  • Lesser omentum attaches to the ligamentum venosum

Fissures of the Liver

  • Main lobar fissure separates the right lobe from the left lobe of the liver and passes through the gallbladder fossa to the inferior vena cava.
  • Right intersegmental fissure divides the right lobe of the liver into anterior and posterior segments.
  • Left intersegmental fissure divides the left lobe into medial and lateral segments.

Liver Spaces

  • Morison pouch (Hepatorenal pouch) is lateral to the right lobe of the liver, anterior to the right kidney, and communicates with the right paracolic space
  • Subhepatic space is inferior to the right lobe of the liver and anterior to the right kidney
  • Subphrenic space is between the superior border of the liver and diaphragm

Vascular Supply

  • Hepatic venous system: portal veins carry blood from the bowel to the liver, hepatic veins drain blood from the liver to inferior vena cava (IVC)
  • Hepatic arteries carry oxygenated blood to the liver
  • Bile ducts transport bile to the duodenum

Hepatic Veins

  • Right middle and left hepatic veins course interlobar and drain directly into the IVC
  • Minimum amount of collagen in the walls
  • Straight and longitudinal course
  • Increase in size closer to the diaphragm
  • Hepatic vein velocity waveform reflects the hemodynamics of the right atrium
  • Triphasic pattern with two large antegrade diastolic and systolic waves, and a small retrograde wave that corresponds to the atrial kick

Hepatic Arteries

  • Proper hepatic artery enters the liver at the porta hepatis, dividing into right, middle, and left hepatic arteries
  • 30% of the liver's blood supply comes through the hepatic artery

Portal Venous System

  • Main right and left portal veins enter at the porta hepatis.
  • Bifurcate into right and left branches
  • 70% of the liver's blood supply
  • Nutrient-rich blood from the digestive tract
  • Walls contain fibrin
  • Normal diameter <13mm

Right Portal Vein

  • Larger of the two portal vein branches
  • Requires a more posterior and more caudal transducer approach.
  • Divides into anterior and posterior divisions

Primary Liver Functions

  • Hepatic metabolic functions: converts sugars into glucose, converts glucose to glycogen and stores it, metabolizes fats into lipoproteins
  • Role in digestion: secretes bile for digestion of fats, breaks down red blood cells into bilirubin
  • Storage function: stores iron and vitamins, detoxifies many drugs and poisons, and waste products of the body's metabolic processes

Indications for Sonographic Evaluation

  • Abnormal liver function tests (LFTs)
  • Hepatocellular disease
  • Biliary disease
  • Abdominal pain
  • Post-prandial pain
  • Gallbladder disease
  • Palpable liver or spleen (PV HTN)
  • Pancreatitis

Liver Segments

  • Key segments include: Segment I (Caudate lobe), Segments II and III (Left superior and inferior lateral segments), Segments IVa and IVb, Segments V and VI (Medial segments of the left lobe, caudal to the transverse plane), Segments VII and VIII (Cephalad to the transverse plane). These segments are determined relative to the hepatic veins (right, middle, and left).

Liver Anomalies

  • Developmental anomalies (agenesis, hypertrophy, anomalies of position – such as Riedel lobe, situs inversus, heterotaxy, and congenital diaphragmatic hernia (CDH).)
  • Inflammation/infections (abscesses, candidiasis, echinococcal cyst, hepatitis, schistosomiasis)
  • Malignant neoplasms (hepatoblastoma, hepatocellular carcinoma, metastases)
  • Vascular-related anomalies (Budd-Chiari syndrome, portal hypertension, portal vein thrombosis)

Benign Hepatic Conditions

  • Fatty infiltration, cirrhosis, focal nodular hypoplasia, adenoma, cavernous hemangioma, glycogen storage disease, hemochromatosis

Liver Trauma

  • The liver is the third most commonly injured abdominal organ after the spleen and kidney.
  • Laceration, hematoma severity determines need for surgery. Right lobe is affected more often than the left.

Liver Transplant

  • Living or deceased donor transplants
  • Section (40-70%) of right lobe of donor liver is transplanted for living donors
  • Orthotopic transplant removes all native liver prior to transplant for deceased donors
  • Check anastomotic sites, and signs of rejection (based on LFTs and biopsy).

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