Liver Anatomy and Functions
45 Questions
3 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which statement accurately describes the function of the main pancreatic duct?

  • It receives secretion from interlobular ducts and joins the bile duct before entering the intestine. (correct)
  • It transports bile from the liver to the digestive tract.
  • It primarily secretes digestive enzymes into the bloodstream.
  • It directly secretes insulin into the bloodstream.
  • What are the characteristics of the islets of Langerhans?

  • They consist of lightly stained polygonal or rounded cells arranged in cords. (correct)
  • They are involved in the secretion of pancreatic digestive enzymes.
  • They are predominantly located in the head of the pancreas.
  • They are mainly responsible for the absorption of nutrients.
  • In the case of acute pancreatitis, which of the following processes does NOT occur?

  • Proteolysis of parenchyma.
  • Enzymatic destruction of adipose cells.
  • Necrosis of blood vessels.
  • Increased production of pancreatic insulin. (correct)
  • What type of cells produce insulin within the islets of Langerhans?

    <p>Beta cells. (D)</p> Signup and view all the answers

    Which condition is characterized by deficient insulin production or defective insulin receptors?

    <p>Diabetes mellitus. (C)</p> Signup and view all the answers

    What is the primary cause of Verner-Morrison syndrome?

    <p>Excessive manufacture and release of VIP due to adenoma of D1 cells. (C)</p> Signup and view all the answers

    Which characteristic distinguishes the endocrine portion of the pancreas from the parotid gland?

    <p>Higher vascularization. (A)</p> Signup and view all the answers

    Which of the following is a common complication of uncontrolled diabetes mellitus?

    <p>Renal failure. (D)</p> Signup and view all the answers

    What causes alcoholic cirrhosis in the liver?

    <p>Hypertrophy of SER and increase in mixed-function oxidases (A)</p> Signup and view all the answers

    What is the role of penicillamine in Wilson's disease?

    <p>Binds to copper and facilitates its elimination from the body (B)</p> Signup and view all the answers

    Which of the following is NOT a feature of gallbladder epithelial cells?

    <p>Presence of well-developed muscularis mucosa (D)</p> Signup and view all the answers

    What type of gland is the exocrine pancreas classified as?

    <p>Compound tubuloacinar gland (A)</p> Signup and view all the answers

    What structural feature is observed in the gallbladder mucosa when distended?

    <p>Smooth appearance with few folds (D)</p> Signup and view all the answers

    Which of the following is true about glycogen in hepatocytes?

    <p>Glycogen is abundant after eating and decreases after fasting (B)</p> Signup and view all the answers

    What triggers the degeneration of hepatocytes in cirrhosis?

    <p>Fibrosis and disintegration of normal liver structure (A)</p> Signup and view all the answers

    Which component of the pancreas is primarily responsible for producing digestive proenzymes?

    <p>Acinar cells (B)</p> Signup and view all the answers

    What is a characteristic feature of Rokitansky-Aschoff sinuses?

    <p>Intercellular spaces involved in fluid transport (D)</p> Signup and view all the answers

    What structure divides the pancreas into distinctive lobules?

    <p>Septae (A)</p> Signup and view all the answers

    Which type of gland is the pancreas classified as?

    <p>Compound tubuloacinar gland (D)</p> Signup and view all the answers

    Which of the following cells are found in the intercalated ducts?

    <p>Cuboidal epithelial cells (C)</p> Signup and view all the answers

    What receptors are located on the basal plasmalemma of centroacinar cells?

    <p>CCK &amp; ACh receptors (A)</p> Signup and view all the answers

    What feature characterizes the cytoplasm of acinar cells?

    <p>Rich supply of polysomes (B)</p> Signup and view all the answers

    What is a distinguishing feature of interlobular ducts?

    <p>Vary considerably in size and sometimes have columnar epithelium (A)</p> Signup and view all the answers

    Which part of the pancreas does the main pancreatic duct lead to?

    <p>Duodenum (A)</p> Signup and view all the answers

    What is the primary function of acinar cells in the pancreas?

    <p>Synthesizing and secreting digestive enzymes (A)</p> Signup and view all the answers

    What is the primary function of the liver's hepatocytes?

    <p>To convert noxious substances into nontoxic materials (B)</p> Signup and view all the answers

    Which of the following is NOT a component of the porta hepatis?

    <p>Central vein (C)</p> Signup and view all the answers

    Which structure separates the limiting plate from the connective tissue of the portal areas in classical lobules?

    <p>Space of Möll (D)</p> Signup and view all the answers

    What shape describes the classical liver lobule?

    <p>Hexagonal (D)</p> Signup and view all the answers

    In the context of liver structure, what does the term 'acinus of Rappaport' specifically relate to?

    <p>Blood flow dynamics and hepatocyte degeneration zones (C)</p> Signup and view all the answers

    What is the role of the portal vein in the liver's vascular supply?

    <p>Carries iron-rich blood from the spleen to the liver (C)</p> Signup and view all the answers

    What changes occur in individuals who have consumed hepatotoxic substances, particularly in relation to liver zones?

    <p>Increased lipid deposits in zone 3 hepatocytes (C)</p> Signup and view all the answers

    Which of the following is the primary anatomical feature of the portal lobule?

    <p>It is characterized by a triangular shape with portal areas at the center. (A)</p> Signup and view all the answers

    Which type of blood vessel provides initial distribution of blood into the liver from the hepatic artery?

    <p>Inlet arterioles (D)</p> Signup and view all the answers

    What type of connective tissue surrounds the liver's Glisson's capsule?

    <p>Dense irregular connective tissue (B)</p> Signup and view all the answers

    Which zone of the liver acinus is most susceptible to necrosis due to low oxygen levels?

    <p>Zone 3 (B)</p> Signup and view all the answers

    What structure facilitates the exchange of materials between blood and hepatocytes?

    <p>Space of Disse (B)</p> Signup and view all the answers

    Which type of collagen fibers are primarily associated with the support of sinusoids?

    <p>Type 3 collagen fibers (B)</p> Signup and view all the answers

    What is the primary function of hepatic stellate cells (Ito cells)?

    <p>Store vitamin A (B)</p> Signup and view all the answers

    What role do Kupffer cells play in the liver?

    <p>Endocytose particulate matter (C)</p> Signup and view all the answers

    Which statement about hepatocytes is true?

    <p>They manufacture primary bile. (C)</p> Signup and view all the answers

    What structure prevents bile leakage in the lateral domains of hepatocytes?

    <p>Tight junctions (A)</p> Signup and view all the answers

    Which feature of hepatocyte plasma membranes increases surface area for material exchange?

    <p>Microvilli (D)</p> Signup and view all the answers

    What is a consequence of long-term usage of barbiturates on hepatocytes?

    <p>Decreased drug effectiveness (D)</p> Signup and view all the answers

    Which cells are known as natural killer cells in the liver?

    <p>Pit cells (A)</p> Signup and view all the answers

    Flashcards

    Liver Size

    The liver weighs approximately 1500 grams.

    Liver Function

    The liver is both an endocrine and exocrine gland, converting harmful substances into harmless ones.

    Glisson's Capsule

    Dense irregular connective tissue surrounding the liver, loosely attached at the porta hepatis.

    Porta Hepatis

    Region where the hepatic artery, portal vein, and bile duct enter the liver.

    Signup and view all the flashcards

    Hepatic Artery

    Blood vessel supplying oxygenated blood to the liver.

    Signup and view all the flashcards

    Portal Vein

    Blood vessel carrying nutrient-rich blood from the digestive system to the liver.

    Signup and view all the flashcards

    Hepatic Sinusoids

    Capillary-like spaces between hepatocytes, enabling blood filtration and exchange by hepatocytes.

    Signup and view all the flashcards

    Classical Lobule

    Hexagon-shaped structures in the liver, with blood flow from the periphery to the center (central vein).

    Signup and view all the flashcards

    Portal Lobule

    Hepatocytes that deliver bile to a specific bile duct.

    Signup and view all the flashcards

    Hepatic Acinus

    Diamond-shaped region of hepatocytes based on blood flow and how they respond to damage.

    Signup and view all the flashcards

    Zone 3 Hepatocytes

    Hepatocytes located in the zone with the lowest oxygen levels, making them most vulnerable to damage.

    Signup and view all the flashcards

    Perisinusoidal Space of Disse

    Narrow space between hepatocytes and sinusoidal lining cells, facilitating exchange of materials between blood and hepatocytes.

    Signup and view all the flashcards

    Hepatic Stellate Cells (Ito cells)

    Cells in the Space of Disse that store vitamin A, produce collagen, and contribute to liver fibrosis.

    Signup and view all the flashcards

    Bile Canaliculi

    Tiny channels between hepatocytes that collect bile, eventually leading to the bile duct.

    Signup and view all the flashcards

    Liver Acinus

    Diamond-shaped region of hepatocytes organized based on blood flow and susceptibility to damage.

    Signup and view all the flashcards

    Hepatocyte Lateral Domains

    Sides of hepatocytes forming bile canaliculi, preventing leakage with tight junctions, and involved in bile production.

    Signup and view all the flashcards

    Hepatocyte Sinusoidal Domains

    Part of hepatocytes facing the Space of Disse with microvilli for increased surface area for exchange with blood.

    Signup and view all the flashcards

    Hepatocyte Organelles

    Hepatocytes are rich in organelles like ribosomes, RER, Golgi, mitochondria, endosomes, lysosomes and peroxisomes involved in bile production.

    Signup and view all the flashcards

    SER Increase in Barbiturate Users

    Long-term use of certain drugs, such as barbiturates, leads to an increase in Smooth Endoplasmic Reticulum (SER) in hepatocytes.

    Signup and view all the flashcards

    Barbiturates and Liver Injury

    Barbiturate users have increased SER content in Zone 3 hepatocytes, making them more vulnerable to liver damage.

    Signup and view all the flashcards

    Drug Tolerance & Liver

    Repeated drug exposure leads to an increase in the smooth endoplasmic reticulum (SER) and mixed-function oxidases in hepatocytes. This adaptation helps the liver process the drug more efficiently, resulting in drug tolerance.

    Signup and view all the flashcards

    Liver's Role in Fat Storage

    The liver stores lipids primarily in the form of very low-density lipoproteins (VLDLs). These lipid droplets are visible within hepatocytes.

    Signup and view all the flashcards

    Glycogen Granules

    Glycogen, the storage form of glucose, appears as electron-dense granules in hepatocytes. These granules are about 20-30 nm in size and are more abundant after a meal and fewer after fasting.

    Signup and view all the flashcards

    Cirrhosis: Liver Scarring

    Cirrhosis is a serious liver condition characterized by fibrosis (scarring) due to degeneration of hepatocytes and disruption of the liver's normal organization. This can be triggered by alcoholism, biliary tract obstruction, or chronic poisoning.

    Signup and view all the flashcards

    Wilson's Disease: Copper Overload

    A genetic disorder where the liver cannot eliminate copper efficiently, leading to its accumulation in the eyes, brain, and liver. This copper buildup can cause cirrhosis and be fatal if untreated. Penicillamine, a chelating agent, can help remove excess copper.

    Signup and view all the flashcards

    Gallbladder Epithelium

    The inner lining of the gallbladder is made of simple columnar epithelium containing mucinogen-producing cells and short microvilli. This epithelium folds into tall parallel ridges that flatten as the gallbladder fills.

    Signup and view all the flashcards

    Gallbladder Epithelial Cells: Energy Production

    The basal region of gallbladder epithelial cells is rich in mitochondria. These mitochondria provide energy for the sodium-potassium pump (Na-K ATPase) located in the basolateral membrane, vital for fluid transport.

    Signup and view all the flashcards

    Rokitansky-Aschoff Sinuses

    These are deep diverticula (outpouchings) found in the gallbladder epithelium. They contribute to fluid movement across the epithelium.

    Signup and view all the flashcards

    Intercellular Spaces in Gallbladder

    The intercellular spaces at the basal part of gallbladder epithelial cells are associated with the transport of fluid across this epithelium. These spaces are also common in intestinal absorptive cells.

    Signup and view all the flashcards

    Gallbladder Lamina Propria

    The layer beneath the gallbladder epithelium contains loose connective tissue, elastic and collagen fibers. In the neck region, it houses simple tubuloalveolar glands that secrete mucus.

    Signup and view all the flashcards

    What is the structural organization of the pancreas?

    The pancreas is a compound tubuloacinar gland, with acini, intercalated ducts, intralobular ducts, interlobular ducts, and a main pancreatic duct. It has septae that divide it into lobules.

    Signup and view all the flashcards

    What is the role of centroacinar (CA) cells?

    CA cells are pale, low cuboidal cells found at the terminus of intercalated ducts within the acini. They receive secretions from acini and contribute to the pancreatic duct system.

    Signup and view all the flashcards

    What are acini and their role?

    Acinar cells in the pancreas are responsible for synthesizing and secreting digestive enzymes. These cells are clustered together in grape-like structures called acini.

    Signup and view all the flashcards

    What is the role of CCK and ACh in pancreatic secretion?

    CCK (Cholecystokinin) and ACh (Acetylcholine) stimulate the release of digestive enzymes from acinar cells by binding to their receptors on the basal cell membrane.

    Signup and view all the flashcards

    What is the function of intercalated ducts?

    Intercalated ducts receive secretions from acini and are lined with flat to cuboidal epithelium. They extend into the acinus to form centroacinar cells.

    Signup and view all the flashcards

    What is the difference between intralobular and interlobular ducts?

    Intralobular ducts receive secretions from intercalated ducts and are lined with cuboidal epithelium, within the lobules. Interlobular ducts are found between lobules and have varying epithelium, from cuboidal to columnar, depending on size.

    Signup and view all the flashcards

    What is the role of the main pancreatic duct?

    The main pancreatic duct receives secretions from interlobular ducts and joins the common bile duct to form the ampulla of Vater, where it releases pancreatic juice into the duodenum.

    Signup and view all the flashcards

    What is the function of secretin?

    Secretin is a hormone that stimulates the secretion of bicarbonate ions from the pancreatic duct cells, helping to neutralize the acidic chyme from the stomach.

    Signup and view all the flashcards

    Main Pancreatic Duct

    The main duct that collects pancreatic secretions from smaller ducts, eventually joining the bile duct before emptying into the duodenum.

    Signup and view all the flashcards

    Interlobular Ducts

    Smaller ducts within the pancreas that collect secretions from acinar cells and deliver them to the main pancreatic duct.

    Signup and view all the flashcards

    Centroacinar Cells

    Specialized epithelial cells located within the lumens of pancreatic acini, contributing to the formation of initial portions of interlobular ducts.

    Signup and view all the flashcards

    Acute Pancreatitis

    A serious inflammation of the pancreas characterized by the activation of digestive enzymes within the pancreatic cells, leading to tissue damage and potential life-threatening complications.

    Signup and view all the flashcards

    Islets of Langerhans

    Specialized clusters of hormone-producing cells scattered throughout the pancreas, responsible for regulating blood sugar levels.

    Signup and view all the flashcards

    Beta Cells

    Cells within the islets of Langerhans that produce insulin, a hormone that lowers blood sugar.

    Signup and view all the flashcards

    Type 1 Diabetes

    An autoimmune disease where the body's immune system destroys beta cells in the pancreas, leading to insufficient insulin production and high blood sugar levels.

    Signup and view all the flashcards

    Verner-Morrison Syndrome

    A rare condition caused by a tumor in the pancreas that produces excessive amounts of vasoactive intestinal peptide (VIP), leading to watery diarrhea, low potassium levels, and low stomach acid.

    Signup and view all the flashcards

    Study Notes

    Liver

    • Approximately 1500g
    • Largest gland
    • Endocrine and exocrine (bile) functions in the same cell (hepatocyte)
    • Converts noxious substances into nontoxic materials

    General Hepatic Structure

    • Covered by Glisson's capsule (dense irregular connective tissue)
    • Loosely attached except at porta hepatis (blood & lymph vessels & bile ducts)
    • Sparse connective tissue within Glisson's capsule

    General Hepatic Structure & Vascular Supply

    • Porta hepatis
    • Left & right hepatic artery
    • Portal vein (nutrients, iron-rich blood from spleen)
    • Right and left hepatic ducts
    • Hepatic veins

    Blood Supply

    • Hepatic artery → distributing arterioles → inlet arterioles
    • Peribiliary capillary plexus around interlobular bile ducts
    • Portal vein → larger distributing veins → smaller inlet venules
    • Central vein: initial branch of hepatic vein
    • Hepatocytes radiate from central vein & separated by hepatic sinusoids

    Types of Liver Lobules

    • Classical lobule
    • Portal lobule
    • Hepatic acinus (acinus of Rappaport)

    Classical Lobule

    • Closely packed classical lobules (hexagon-shaped)
    • Boundaries can only be approximated
    • 3 lobules contact portal areas (triads)
    • Hepatic artery, portal vein, and bile duct

    Portal Lobule

    • All hepatocytes that deliver their bile to a particular bile duct constitute a portal lobule
    • Triangular region
    • Portal area at the center
    • Imaginary straight lines connecting 3 central veins

    Hepatic Acinus (Acinus of Rappaport)

    • Based on blood flow from distributing arteriole
    • Hepatocytes degenerate subsequent to toxic or hypoxic insults
    • Ovoid to diamond-shaped lobule
    • Zone 1, Zone 2, Zone 3

    Hepatic Sinusoids & Hepatocyte Plates

    • Plates of hepatocytes radiate from central vein toward periphery of classical lobule
    • Spaces between plates: sinusoids
    • Sinusoidal lining cells
    • Gaps between lining cells
    • Fenestrae in clusters: sieve plates

    Kupffer cells in Sinusoids

    • Endocytose particulate matter and cellular debris, defunct erythrocytes

    Perisinusoidal Space of Disse

    • Narrow space between a plate of hepatocytes and sinusoidal lining cells
    • Microvilli of hepatocytes, exchange of materials between blood & hepatocytes

    Perisinusoidal Space of Disse

    • Type 3 collagen (reticular) fibers, supporting sinusoids
    • Type 1 & 4 collagen fibers
    • No basal lamina
    • Nonmyelinated nerve fibers

    Space of Disse

    • Hepatic stellate cells (Ito cells): fat storing cells
    • Store vitamin A
    • Manufacture & release type 3 collagen
    • Secrete growth factors
    • Form fibrous connective tissue to replace damaged hepatocytes
    • Pit cells
    • Natural killer cells

    Hepatic Ducts

    • Bile canaliculi
    • Canals of Hering (Cholangioles)
    • Interlobular bile ducts
    • Right & left hepatic ducts

    Hepatocytes

    • 5-12 sided polygonal cells
    • 20-30 µm diameter
    • Closely packed to form one or two cell-thick plates
    • Show variations in their structural, histochemical & biochemical properties depending on their location within lobules

    Domains of Hepatocyte Plasmalemma

    • Lateral domains
    • Formation of bile canaliculi
    • Bile leakage prevented by tight junctions
    • High levels of Na, K-ATPase activity & adenylate cyclase
    • Gap junctions

    Domains of Hepatocyte Plasmalemma

    • Sinusoidal domains
    • Microvilli projecting into space of Disse
    • Increase surface area, facilitating exchange between hepatocyte and plasma in perisinusoidal space
    • Mannose-6-phosphate receptors
    • Na, K-ATPASE
    • Adenylate cyclase
    • Endocrine secretions of hepatocytes released & enter sinusoidal blood
    • Material from blood transported into hepatocyte cytoplasm

    Hepatocyte Organelles and Inclusions

    • Manufacture primary bile
    • Abundant free ribosomes, RER, Golgi
    • 2000 mitochondria
    • Rich in endosome, lysosome & peroxisome
    • SER
    • Certain drugs & toxins increase SER

    Hepatocyte

    • Lipid droplets (mostly VLDLs)
    • Glycogen
    • Electron-dense granules (20-30 nm in size)
    • Abundant after eating, fewer after fasting

    Acute Pancreatitis

    • Pancreatic digestive enzymes become active within cytoplasm of acinar cells
    • Often fatal
    • Inflammatory reaction, necrosis of blood vessels, proteolysis of parenchyma, enzymatic destruction of adipose cells

    Islets of Langerhans

    • Scattered among acini
    • Richly vascularized
    • Spherical conglomeration of 3000 cells
    • 1 million islets
    • Greater number in tail
    • Surrounded by reticular fibers

    Cells of Islets

    • 5 types:
    • Beta
    • Alpha
    • Delta (D&D1)
    • PP (pancreatic polypeptide-producing)
    • G (gastrin-producing)

    Differences from Parotid Gland

    • Exocrine part similar in structure to parotid gland
    • Absence of striated ducts
    • Presence of islets of Langerhans
    • Initial parts of ICDs penetrate lumens of acini
    • Centroacinar cells (nuclei surrounded by pale cytoplasm)

    Diabetes Mellitus

    • Hyperglycemic metabolic disorder
    • Lack of insulin production from B cells or defective insulin receptors
    • If uncontrolled: circulatory disorders, renal failure, blindness, gangrene, stroke, myocardial infarct

    Type 1 Diabetes

    • Usually affects persons <20 years of age
    • Polydipsia (constant thirst)
    • Polyphagia (undiminished hunger)
    • Polyuria (excessive urination)

    Type 2 Diabetes

    • Non-insulin-dependent diabetes
    • The most common type
    • Affects persons >40 years of age

    Verner-Morrison Syndrome

    • Explosive, watery diarrhea
    • Hypokalemia
    • Caused by excessive manufacture and release of VIP due to adenoma of D1 cells
    • Frequently, tumors of D1 cells are malignant

    Gallbladder

    • Simple columnar epithelium
    • Mucinogen
    • Short microvilli
    • Lamina propria
    • Smooth muscle
    • Serosa/adventitia

    Gallbladder Epithelial Cells

    • Basally positioned oval nuclei
    • Short microvilli coated by glycocalyx (carb rich coat → acid barrier)
    • Basal region rich in mitochondria, providing abundant energy for Na-K ATPase pump in basolateral membrane
    • Deep diverticula called Rokitansky-Aschoff sinuses

    Gallbladder Intercellular Spaces

    • Feature associated with transport of fluid across epithelium
    • Commonly seen in intestinal absorptive cells

    Gallbladder Lamina Propria

    • Loose connective tissue
    • Elastic & collagen fibers
    • Neck: simple tubuloalveolar glands (mucus)

    Gallbladder Smooth Muscle Layer

    • Mostly obliquely oriented fibers
    • Others longitudinally oriented
    • Adventitia attached to Glisson's capsule
    • Nonattached surface invested by peritoneum

    Extrahepatic Ducts

    • Right hepatic duct
    • Left hepatic duct
    • Common hepatic duct
    • Cystic duct
    • Common bile duct
    • Pancreatic duct
    • Ampulla of Vater

    Pancreas

    • Posterior body wall deep to the peritoneum
    •  Four regions: Uncinate process, Head, Body, Tail
    • 25 cm long, 5 cm wide, 1-2 cm thick, 150 g

    Exocrine Pancreas

    • Compound tubuloacinar gland
    • Produces bicarbonate-rich fluid & digestive proenzymes (1200 ml/day)
    • 40-50 acinar cells form a round to oval acinus
    • Lumen occupied by 3-4 centroacinar cells (distinguishing characteristic, beginning of duct system)
    • Surrounded by BL supported by reticular fibers

    Acinar Cell

    • Like a truncated pyramid
    • Base positioned on BL, separating cell from CT
    • Basally located round nucleus, surrounded by basophilic cytoplasm
    • Apex faces the lumen
    • Apex filled with zymogen granules, eosinophilic
    • Number diminishes after meal
    • Golgi region between nucleus and zymogen granules varies in size in inverse relation to zymogen granule concentration
    • Base contains many parallel cisternae of GER (basophilic staining in LM)
    • Golgi apparatus fluctuates in size (smaller when zymogen granules numerous, larger after granules release their content)
    • Microvilli from apical surface
    • Z. occludentes (tight junction) at an apicolparcian

    Islets of Langerhans

    • Lightly stained polygonal or rounded cells arranged in cords separated by a network of fenestrated capillaries.
    • Both parenchymal cells & blood vessels are innervated by ANS.

    Pancreatic Duct

    • ICD (Intralobular ducts)
    • Interlobular duct
    • Main pancreatic duct
    •  Common bile duct
    • Papilla of Vater

    Intercalated Ducts

    • Receive secretions from acini
    • Flattened to cuboidal epithelium that extends up into the lumen of the acinus to form centroacinar cells

    Intralobular Ducts

    • Cuboidal epithelium
    • Within lobules
    • Receive secretions from intercalated ducts

    Interlobular Ducts

    • Between lobules, within the connective tissue septae
    • Vary considerably in size
    • Smaller forms have cuboidal epithelium
    • Larger ducts have columnar epithelium
    • Transmit secretions from intralobular ducts to major pancreatic duct

    The Main Pancreatic Duct

    • Receives secretion from interlobular ducts
    • Penetrates through the wall of duodenum
    • Joins the bile duct prior to entering the intestine

    Pancreas H&E

    • Acinar cells
    • Centroacinar cells
    • Connective tissue
    • Exocrine secretory tissue

    Secretory Portion

    • Basal cell membranes of acinar cells have receptors for CCK & ACh
    • Abundance of basally located RER
    • Rich supply of polysomes
    • Numerous mitochondria
    • Golgi well developed

    Duct System

    • Begins within center of acinus with terminus of intercalated ducts (ICD)
    • Pale, low cuboidal centroacinar (CA) cells
    • CA cells & ICDs have receptors on basal plasmalemma for secretin & possibly for ACh

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Liver Anatomy PDF

    Description

    Explore the intricate structure and vital functions of the liver in this quiz. From its role as the largest gland in the body to its unique vascular supply system, you'll test your knowledge on various liver lobules and their significance. Understand how hepatocytes work to detoxify substances within the liver.

    More Like This

    Liver Anatomy and Function Quiz
    46 questions

    Liver Anatomy and Function Quiz

    ThankfulAntigorite6503 avatar
    ThankfulAntigorite6503
    Hepatic Circulation and Liver Structure
    34 questions
    Liver Anatomy and Function Quiz
    43 questions
    Human Anatomy Chapter on Liver and Vascular System
    61 questions
    Use Quizgecko on...
    Browser
    Browser