Live Attenuated Vaccines: Advantages and Disadvantages

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Questions and Answers

What is the role of dendritic cells and macrophages after a vaccine is injected?

  • Activate the lymphocytes directly
  • Take up the components of the vaccine with the help of PRRs (correct)
  • Initiate the formation of memory B and T cells
  • Produce antibodies to fight the pathogen

What do Antigen-presenting cells (APCs) do after getting activated?

  • Directly attack the pathogen
  • Move towards lymph nodes in near areas (correct)
  • Release pathogen-associated molecular patterns (PAMPs)
  • Produce antibodies to fight the pathogen

What is the outcome of antigen recognition by lymphocytes?

  • Clonal expansion of antigen-specific B and T-lymphocytes (correct)
  • Activation of dendritic cells and macrophages
  • Formation of memory B and T cells
  • Release of pathogen-associated molecular patterns (PAMPs)

How does long-term protection against the pathogen occur?

<p>When memory B and T cells are formed (C)</p> Signup and view all the answers

Which type of vaccines can induce the expression of antigens that resemble native viral epitopes more closely than standard vaccines?

<p>DNA/mRNA vaccines (A)</p> Signup and view all the answers

What is the major disadvantage of DNA/mRNA vaccines according to the text?

<p>They cannot be the substitute for polysaccharide-based subunit vaccines (A)</p> Signup and view all the answers

What is the advantage of DNA/mRNA vaccines in terms of antigen expression?

<p>They can induce the expression of antigens that resemble native viral epitopes more closely than standard vaccines (A)</p> Signup and view all the answers

Why are DNA/mRNA vaccines considered advantageous for rapid, large-scale production?

<p>Sequences can be produced quickly, and the coding sequence can be manipulated in many ways (A)</p> Signup and view all the answers

What limits the extent of the usage of DNA vaccines according to the text?

<p>Outer capsids made up of polysaccharides in certain microbes (D)</p> Signup and view all the answers

In what way do DNA/mRNA vaccines differ from live attenuated and killed vaccines?

<p>DNA/mRNA vaccines can induce the expression of antigens that resemble native viral epitopes more closely than standard vaccines (C)</p> Signup and view all the answers

Which vaccine-preventable disease had a 100% reduction in morbidities postvaccine?

<p>Smallpox (D)</p> Signup and view all the answers

What was the estimated annual morbidity reduction percentage for measles postvaccine?

<p>99% (D)</p> Signup and view all the answers

Which region experienced the world's second largest Ebola outbreak in 2018-2020?

<p>The Democratic Republic of the Congo (DRC) (A)</p> Signup and view all the answers

What was the case-fatality rate of Ebola virus disease (EVD) mentioned in the text?

<p>90% (B)</p> Signup and view all the answers

What was the outcome post vaccinations for the 2018-2020 Ebola outbreak?

<p>~98% effective in stopping Ebola virus transmission (D)</p> Signup and view all the answers

What is the key feature of live attenuated vaccines according to the text?

<p>They are prepared from attenuated strains almost devoid of pathogenicity (C)</p> Signup and view all the answers

How are live, attenuated vaccines prepared according to the text?

<p>By serial passages through a foreign host for multiple generations (B)</p> Signup and view all the answers

What measure was taken by the DRC's ministry of health in response to the 2018-2020 Ebola outbreak, as mentioned in the text?

<p>Enhanced surveillance and systematic screening of travelers (D)</p> Signup and view all the answers

What was unique about the rVSV-ZEBOV-GP vaccine mentioned in the text?

<p>It was given conditional marketing authorization due to its effectiveness (D)</p> Signup and view all the answers

How many lives are estimated to be saved every year because of vaccines according to the text?

<p>2-3 million lives (C)</p> Signup and view all the answers

Which type of vaccine can often confer lifelong immunity with only one or two doses?

<p>Live, attenuated vaccines (D)</p> Signup and view all the answers

What is a drawback of inactivated whole virus vaccines in areas where people don’t have regular access to health care?

<p>They stimulate a weaker immune response than live vaccines (C)</p> Signup and view all the answers

What is a disadvantage of live, attenuated vaccines for individuals with weakened immune systems?

<p>They can't be given to individuals with weakened immune systems (B)</p> Signup and view all the answers

What is the main advantage of inactivated whole virus vaccines over live, attenuated vaccines?

<p>They are cheaper and easily accessible to people in developing countries (C)</p> Signup and view all the answers

Which type of vaccine is made by purifying the bacterial exotoxin and suppressing or inactivating its toxicity?

<p>Toxoid vaccines (B)</p> Signup and view all the answers

What is the key feature of DNA vaccines in terms of antigen expression?

<p>They directly introduce plasmids into the appropriate tissue (C)</p> Signup and view all the answers

What technology involves sequencing the genome of a pathogen to specifically select a virulence factor responsible for causing disease?

<p>Next generation technologies Reverse vaccinology (C)</p> Signup and view all the answers

Which type of vaccine stimulates a weaker immune response than do live vaccines?

<p>Inactivated/Inert/Killed (antigen) vaccines (B)</p> Signup and view all the answers

Why do conjugate vaccines attach polysaccharides to a stronger protein?

<p>To disguise bacterial antigens so that immature immune systems can't recognize them (C)</p> Signup and view all the answers

What is the main advantage of nucleic acid vaccines compared to traditional vaccines?

<p>They are quick to make and less expensive (D)</p> Signup and view all the answers

What is the main advantage of DNA/mRNA vaccines for rapid, large-scale production?

<p>They are easy and quick to make (D)</p> Signup and view all the answers

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