Lec 3- Liquid Dosage Forms: Overview
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Questions and Answers

Which route of administration is commonly used for liquid dosage forms?

  • Oral
  • Intramuscular (correct)
  • Subcutaneous
  • Intradermal

What is the MAIN advantage of liquid dosage forms for patients who have difficulty swallowing?

  • Increased stability
  • Easier administration (correct)
  • Enhanced taste
  • Reduced cost

What is an important objective related to bioavailability in dosage form design?

  • The drug must be commercially acceptable.
  • The drug must be easy to manufacture.
  • The drug must exert its pharmacologic effect. (correct)
  • The drug must be stable.

Why is patient compliance important when formulating dosage forms?

<p>To increase the stability of the drug (B)</p> Signup and view all the answers

What is the active pharmaceutical ingredient (API) in a dosage form?

<p>The substance that protects the dosage form (C)</p> Signup and view all the answers

What is the function of excipients in a dosage form?

<p>To protect the packaging (C)</p> Signup and view all the answers

What is the purpose of a Certificate of Analysis (CoA) for an API?

<p>To determine the source of the drug (B)</p> Signup and view all the answers

What is one reason why a pharmacist might need to compound a drug?

<p>To increase the drug's cost (B)</p> Signup and view all the answers

Which of the following dosage forms is a clear, homogenous preparation?

<p>Suspension (C)</p> Signup and view all the answers

In a solution, what type of solvent is water?

<p>Acidic (D)</p> Signup and view all the answers

Which of the following is a disadvantage of solutions compared to solid dosage forms?

<p>Less stable (C)</p> Signup and view all the answers

What is the purpose of adding flavoring to oral solutions?

<p>To increase stability (B)</p> Signup and view all the answers

Which of the following should be evaluated when considering compounding a prescription?

<p>Is the packaging environmentally friendly? (B)</p> Signup and view all the answers

What is the first step in compounding preparation after evaluating the prescription?

<p>Calibrating equipment (C)</p> Signup and view all the answers

Why is it important to determine if a drug will dissolve in the desired solvent during compounding?

<p>To determine the packaging requirements (B)</p> Signup and view all the answers

What formulation process helps in achieving the desired particle size?

<p>Dissolve the solute in the solvent (C)</p> Signup and view all the answers

What type of liquid preparation has solid particles dispersed in a liquid phase?

<p>Solution (B)</p> Signup and view all the answers

Which of the following is a reason to make a drug into a suspension?

<p>Mask taste of drugs (C)</p> Signup and view all the answers

What is a key property of an ideal pharmaceutical suspension?

<p>Large Particle size (C)</p> Signup and view all the answers

According to Stokes Law, which particles settle faster in a suspension?

<p>Particles of larger diameter (C)</p> Signup and view all the answers

What is the role of a wetting/levigating agent in a suspension?

<p>To disperse solids in a liquid phase (D)</p> Signup and view all the answers

What is the purpose of using buffers in suspensions?

<p>To enhance the flavor (B)</p> Signup and view all the answers

Which of the following is an example of a suspending agent?

<p>Coloring (A)</p> Signup and view all the answers

What does the viscosity of a liquid measure?

<p>Color (B)</p> Signup and view all the answers

In preparing methylcellulose, what is the first step?

<p>Calculate the amount needed (B)</p> Signup and view all the answers

What is the nature of an emulsion?

<p>Two-phase systems (C)</p> Signup and view all the answers

What's the function of an emulsifying agent?

<p>Reduce interfacial tension (C)</p> Signup and view all the answers

What is the dispersed phase in an emulsion?

<p>Internal phase (B)</p> Signup and view all the answers

What factor is considered reasons for making an emulsion?

<p>Reduce costs (B)</p> Signup and view all the answers

What is a liquid dosage form?

<p>A semi-solid form of a chemical compound. (C)</p> Signup and view all the answers

Which of the following routes of administration is suitable for liquid dosage forms?

<p>All of the above (D)</p> Signup and view all the answers

Why are liquid dosage forms useful for pediatric patients?

<p>They are always cheaper than solid dosage forms. (B)</p> Signup and view all the answers

What is considered an advantage of liquid dosage forms regarding dosing?

<p>Flexibility in dosing. (C)</p> Signup and view all the answers

What is the term for the extent a drug is available to exert its pharmacologic effect?

<p>Stability (B)</p> Signup and view all the answers

Which of the following is an objective in dosage form design to ensure the product remains suitable for use?

<p>Compliance (B)</p> Signup and view all the answers

What is the term for how well a patient adheres to taking their medicine as prescribed?

<p>Marketing (C)</p> Signup and view all the answers

What influences dosage form design due to the need of commercial acceptance?

<p>Bioavailability (D)</p> Signup and view all the answers

Which of the following describes the active ingredient (API) in a dosage form?

<p>The reason to take the dosage form. (C)</p> Signup and view all the answers

Excipients primarily function to:

<p>Determine the marketing strategy of the drug. (C)</p> Signup and view all the answers

What is the purpose of packaging in a dosage form?

<p>To enhance the flavor of the medication. (B)</p> Signup and view all the answers

What are materials and equipment needed for dispensing of the medication known as?

<p>Administration Device (C)</p> Signup and view all the answers

What is considered a source of an API?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is an example of a high-quality ingredient standard for APIs?

<p>All of the above (D)</p> Signup and view all the answers

A pharmacy may compound drugs for:

<p>Stockpiling for future use. (C)</p> Signup and view all the answers

Which of the following is a valid reason for compounding a drug?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following describes a solution dosage form?

<p>A preparation that requires filtration before use. (B)</p> Signup and view all the answers

How does a solute dissolve best in a solvent?

<p>It has a different viscosity. (B)</p> Signup and view all the answers

Which of the following is an example of an aqueous solvent?

<p>Ethanol (D)</p> Signup and view all the answers

Which of the following ingredients lacks pharmacological activity and can be tasteless?

<p>Oils (C)</p> Signup and view all the answers

Which type of solution is best suited for water-soluble drugs?

<p>Syrups (A)</p> Signup and view all the answers

Why are lipid soluble drugs best suited for use in oil?

<p>Oil increases the rate of dissolution (C)</p> Signup and view all the answers

What is considered a type of solution?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is an advantage of solutions?

<p>Increase adverse effects in the GI. (B)</p> Signup and view all the answers

In compounding, performing hand hygiene occurs during?

<p>Washing equipment. (C)</p> Signup and view all the answers

Solubility is most important to determine when?

<p>Compounding suspensions (B)</p> Signup and view all the answers

What comes after preparing the ingredients during compounding solutions?

<p>Flavoring (C)</p> Signup and view all the answers

What is a liquid preparation with solid particles dispersed throughout a liquid phase?

<p>Tincture (B)</p> Signup and view all the answers

Which is a kind of suspension?

<p>All of the above (D)</p> Signup and view all the answers

Why is masking taste important when making a suspension?

<p>Suspensions have flavoring agents added (D)</p> Signup and view all the answers

What is the primary role of pharmaceutical liquid products?

<p>To make drugs more expensive (A)</p> Signup and view all the answers

Which of the following best describes a solution in pharmaceutical terms?

<p>A solid dosage form (B)</p> Signup and view all the answers

What is a key characteristic of syrups as a type of solution?

<p>Low sugar concentration (B)</p> Signup and view all the answers

Why do suspensions require shaking before administration?

<p>To increase the temperature of the liquid (B)</p> Signup and view all the answers

What are emulsions in the context of liquid pharmaceuticals?

<p>Homogenous mixtures of solids in liquids (B)</p> Signup and view all the answers

What is the purpose of purified water in pharmaceutical preparations?

<p>As a coloring agent (C)</p> Signup and view all the answers

Which compounding technique involves reducing particle size by grinding?

<p>Levigation (C)</p> Signup and view all the answers

What is a critical factor to consider when formulating liquid products regarding the drug?

<p>Smell of the drug (B)</p> Signup and view all the answers

Why are amber-colored bottles often used for packaging liquid pharmaceuticals?

<p>To improve the taste (B)</p> Signup and view all the answers

What is the purpose of quality control testing for liquid pharmaceutical products?

<p>To ensure products meet quality standards (B)</p> Signup and view all the answers

What is the primary characteristic of a liquid dosage form?

<p>Solid particles dispersed in a liquid (B)</p> Signup and view all the answers

Which route of administration involves applying a liquid dosage form to the skin?

<p>Parenteral (B)</p> Signup and view all the answers

For patients who find it difficult to swallow solid medications, liquid dosage forms offer what advantage?

<p>Easier administration (B)</p> Signup and view all the answers

What is 'bioavailability' in the context of dosage forms?

<p>The storage temperature requirements (B)</p> Signup and view all the answers

What is a key consideration for patient compliance in dosage form design?

<p>The manufacturing process (B)</p> Signup and view all the answers

What does 'API' stand for in pharmaceutical formulations?

<p>Inactive Pharmaceutical Ingredient (B)</p> Signup and view all the answers

What is the role of 'excipients' in a dosage form?

<p>To provide the main therapeutic effect (B)</p> Signup and view all the answers

What is the purpose of a Certificate of Analysis (CoA)?

<p>To apply for a drug patent (B)</p> Signup and view all the answers

Why might a pharmacist need to compound a drug?

<p>To change the formulation for a specific patient (B)</p> Signup and view all the answers

Which of the following is a characteristic of a 'solution' as a dosage form?

<p>Contains undissolved solid particles (B)</p> Signup and view all the answers

In a pharmaceutical solution, what is water typically used as?

<p>A flavoring agent (B)</p> Signup and view all the answers

What is a disadvantage of solutions compared to solid dosage forms like tablets?

<p>Slower absorption rate (C)</p> Signup and view all the answers

Why is flavoring added to oral solutions, especially for pediatric use?

<p>To increase the drug's solubility (B)</p> Signup and view all the answers

When considering compounding a prescription, what is an essential first step?

<p>Cleaning the equipment (B)</p> Signup and view all the answers

After evaluating a prescription for compounding, what is typically the next step in preparing a solution?

<p>Dissolving the solute (A)</p> Signup and view all the answers

Why is determining drug solubility important in compounding solutions?

<p>To calculate the cost of ingredients (B)</p> Signup and view all the answers

In compounding solutions, reducing particle size of the solute helps primarily in:

<p>Preventing sedimentation (B)</p> Signup and view all the answers

What type of liquid preparation is characterized by solid particles dispersed in a liquid medium?

<p>Elixir (B)</p> Signup and view all the answers

What is a primary reason to formulate a drug as a suspension instead of a solution?

<p>To improve the taste of a bitter drug (B)</p> Signup and view all the answers

Which of these is a desirable property of a pharmaceutical suspension?

<p>Formation of a hard cake upon settling (C)</p> Signup and view all the answers

According to Stokes' Law, which type of particles will settle faster in a suspension?

<p>Low density particles (C)</p> Signup and view all the answers

What is the function of a 'wetting' or 'levigating' agent in preparing a suspension?

<p>To increase the viscosity of the suspension (B)</p> Signup and view all the answers

Why are buffers used in pharmaceutical suspensions?

<p>To improve taste (B)</p> Signup and view all the answers

Which of the following is an example of a suspending agent used to increase viscosity and prevent settling?

<p>Methylcellulose (B)</p> Signup and view all the answers

In the preparation of methylcellulose suspension, what is the first step in methylcellulose preparation itself?

<p>Hydration (D)</p> Signup and view all the answers

What is the fundamental nature of an emulsion?

<p>A homogenous mixture of two liquids (C)</p> Signup and view all the answers

What is the role of an emulsifying agent?

<p>To act as a preservative (B)</p> Signup and view all the answers

In an emulsion, what is the 'dispersed phase'?

<p>The liquid that is broken into small droplets (B)</p> Signup and view all the answers

Which of the following is a reason for formulating a drug as an emulsion?

<p>To make the formulation less viscous (B)</p> Signup and view all the answers

For a patient experiencing dysphagia, which characteristic of liquid dosage forms is MOST beneficial?

<p>Prolonged drug release profiles (B)</p> Signup and view all the answers

Considering dosage form objectives, if a drug product is not adequately stable over its shelf life, which primary objective is MOST directly compromised?

<p>Marketing (D)</p> Signup and view all the answers

In a pharmaceutical formulation, what is the PRIMARY role of the Active Pharmaceutical Ingredient (API)?

<p>To enhance the dosage form's palatability (B)</p> Signup and view all the answers

Which document assures the quality and purity of an Active Pharmaceutical Ingredient (API) and is essential during pharmaceutical compounding?

<p>Material Safety Data Sheet (MSDS) (B)</p> Signup and view all the answers

A pharmacist needs to compound an oral solution of a medication that is commercially available as tablets but not in liquid form. Which of the following is the MOST likely reason for compounding in this scenario?

<p>To improve the drug's stability (D)</p> Signup and view all the answers

In pharmaceutical solutions, why is 'like dissolves like' a critical principle when selecting a solvent?

<p>To maximize the solubility of the solute (B)</p> Signup and view all the answers

Which of the following solvents is classified as an aqueous solvent commonly used in pharmaceutical solutions?

<p>Glycerol (C)</p> Signup and view all the answers

Syrups, as a type of solution, are characterized by a high concentration of which ingredient?

<p>Alcohol (C)</p> Signup and view all the answers

What is a key disadvantage of liquid solutions compared to solid dosage forms like tablets or capsules regarding drug product stability?

<p>Lower bioavailability (C)</p> Signup and view all the answers

In compounding a solution, hand hygiene is a critical step. At which stage of the compounding process is hand hygiene MOST appropriately performed?

<p>Before beginning any compounding activity (B)</p> Signup and view all the answers

When compounding a solution, determining the solubility of the drug substance in the intended solvent is crucial. At which point in the compounding process is solubility determination MOST important?

<p>During the particle size reduction step (B)</p> Signup and view all the answers

In the preparation of a pharmaceutical solution by compounding, what is the purpose of reducing the particle size of the solute?

<p>To enhance the aesthetic appeal of the solution (C)</p> Signup and view all the answers

Which type of liquid pharmaceutical preparation is characterized by solid drug particles that are NOT dissolved but are dispersed throughout a liquid vehicle?

<p>Syrup (C)</p> Signup and view all the answers

For which of the following reasons is a drug substance MOST likely formulated as a suspension rather than a solution?

<p>To improve drug homogeneity (C)</p> Signup and view all the answers

According to Stokes' Law, which of the following particle characteristics will lead to a FASTER settling rate in a pharmaceutical suspension?

<p>Decreased particle density (D)</p> Signup and view all the answers

What is the primary function of a wetting or levigating agent in the compounding of a pharmaceutical suspension?

<p>To facilitate the dispersion of solid particles in the liquid vehicle (C)</p> Signup and view all the answers

Buffers are commonly used in pharmaceutical suspensions. What is the MAIN purpose of incorporating buffers into these formulations?

<p>To maintain the suspension's viscosity (C)</p> Signup and view all the answers

Methylcellulose is used in pharmaceutical suspensions primarily for which of the following roles?

<p>Preservative (C)</p> Signup and view all the answers

In the context of liquid pharmaceuticals, what does the term 'viscosity' primarily measure?

<p>The color intensity of the liquid (C)</p> Signup and view all the answers

When preparing a methylcellulose suspension, what is the INITIAL step in the methylcellulose preparation process to ensure proper hydration and dispersion?

<p>Levigating with glycerin (D)</p> Signup and view all the answers

What is the fundamental nature of a pharmaceutical emulsion as a dosage form?

<p>A dispersion of two immiscible liquids (D)</p> Signup and view all the answers

What is the CRITICAL function of an emulsifying agent in an emulsion formulation?

<p>To increase the viscosity of the emulsion (B)</p> Signup and view all the answers

In an oil-in-water (o/w) emulsion, which component constitutes the dispersed phase?

<p>Oil (B)</p> Signup and view all the answers

Which of the following is a PRIMARY reason for formulating a drug as an emulsion?

<p>To improve the taste of an unpleasant-tasting drug (B)</p> Signup and view all the answers

When preparing an emulsion using the dry gum method (Continental method), what is the ratio of oil, water, and gum (emulsifier) typically used?

<p>1:1:1 (B)</p> Signup and view all the answers

What is a key characteristic of flocculation in emulsions, which distinguishes it from coalescence?

<p>Increase in droplet size due to merging (C)</p> Signup and view all the answers

Which of the following is considered an UNDESIRABLE property of a liquid emulsion, indicating instability?

<p>Ease of redispersion (D)</p> Signup and view all the answers

In emulsion terminology, what does 'creaming' refer to?

<p>Merging of small droplets into larger ones (C)</p> Signup and view all the answers

Considering the Hydrophilic-Lipophilic Balance (HLB) system, an emulsifier with a HIGH HLB value (>10) is BEST suited for which type of emulsion?

<p>Water-in-oil (w/o) emulsions (B)</p> Signup and view all the answers

During the compounding of a liquid dosage form, if the order of mixing is not properly followed and an excessive amount of the internal phase is added too quickly, what potential issue might occur in an emulsion?

<p>Increased viscosity (B)</p> Signup and view all the answers

In the formulation of liquid dosage forms, why is incorporating the drug substance into an oil or water phase a common method?

<p>To bypass the need for solubility enhancement. (C)</p> Signup and view all the answers

Considering the dosage form objective of stability, which factor would MOST significantly challenge the stability of a liquid dosage form?

<p>Maintaining a consistent manufacturing process to ensure uniformity. (C)</p> Signup and view all the answers

What is the MOST critical reason for using high-quality ingredients, such as those listed in the USP-NF, when compounding liquid dosage forms?

<p>To comply with marketing regulations and trademark requirements. (C)</p> Signup and view all the answers

A pharmacist needs to compound a liquid formulation because the commercially available product contains an excipient to which the patient is allergic. Which of the following describes this scenario?

<p>Avoiding an excipient (B)</p> Signup and view all the answers

When compounding a solution, the pharmacist finds that the active pharmaceutical ingredient (API) is slow to dissolve in the solvent. What is the MOST appropriate next step to improve the dissolution rate?

<p>Increase the viscosity of the solvent. (B)</p> Signup and view all the answers

If a compounded oral suspension is intended to mask the extremely bitter taste of an active drug, what formulation approach would be MOST effective?

<p>Increasing drug solubility (D)</p> Signup and view all the answers

A pharmacist is formulating a suspension and observes rapid settling of the dispersed particles. According to Stokes' Law, what adjustment would MOST effectively reduce the settling rate?

<p>Increasing the density of the continuous phase. (C)</p> Signup and view all the answers

What is the PRIMARY reason for incorporating buffers into a pharmaceutical suspension?

<p>To prevent microbial growth. (D)</p> Signup and view all the answers

In the preparation of a methylcellulose suspension, what is the MOST important reason for initially hydrating the methylcellulose with purified water?

<p>To accelerate drug dissolution (C)</p> Signup and view all the answers

In an unstable emulsion, what is the phenomenon of 'coalescence' characterized by?

<p>The formation of a structured network of particles held together by weak forces. (C)</p> Signup and view all the answers

What primary issue arises from adding an excessive amount of the internal phase too quickly during the preparation of an emulsion?

<p>Increased viscosity of the external phase. (C)</p> Signup and view all the answers

Which route of administration is MOST suitable for liquid dosage forms needing rapid drug absorption and a bypass of first-pass metabolism?

<p>Inhalation (D)</p> Signup and view all the answers

Which of the following BEST balances patient compliance alongside taste-masking when formulating oral liquid medications for pediatric patients?

<p>Utilizing the most potent, but potentially aversive, flavoring agents to ensure complete taste masking. (C)</p> Signup and view all the answers

What is the MOST essential consideration regarding the API when initially evaluating a prescription for a compounded liquid medication?

<p>The API’s cost to minimize financial burden on the patient. (C)</p> Signup and view all the answers

What primary role do inactive excipients serve in liquid dosage form manufacturing?

<p>Guarantee therapeutic efficacy. (D)</p> Signup and view all the answers

What characteristic is unique solely to solutions when compared to other liquid dosage forms?

<p>They contain undissolved particles. (C)</p> Signup and view all the answers

What is the intended use of a aromatic water when formulating it with an API?

<p>To adjust the pH of the solution. (C)</p> Signup and view all the answers

Which factor MOST limits the use of oils in liquid dosage formulations?

<p>Their limited usecase for water soluble drugs (D)</p> Signup and view all the answers

Why do liquid dosage forms typically have a shorter expiration date compared to solid dosage forms?

<p>There is a rapid drug absorption. (D)</p> Signup and view all the answers

Which of the following considerations is LEAST relevant when evaluating a prescription for compounding?

<p>The patient appropriateness (C)</p> Signup and view all the answers

In the context of compounding, what is the significance of a drug's 'stability' in a solution?

<p>How well the drug interacts with flavoring agents. (B)</p> Signup and view all the answers

During the preparation of a suspension, what does the term’ levigation' MOST accurately describe?

<p>The process of dissolving a solid in a liquid. (D)</p> Signup and view all the answers

In preparing suspensions, why is using a structured vehicle more advantageous than using an unstructured vehicle such as purified water alone?

<p>It improves flavor and color. (D)</p> Signup and view all the answers

How does viscosity impact the performance and stability of pharmaceutical suspensions MOST directly?

<p>Prevents particle aggregation (C)</p> Signup and view all the answers

In the context of emulsions, what does the term 'phase inversion' refer to?

<p>The switch of the dispersed phase becoming the continuous and vice versa. (D)</p> Signup and view all the answers

If an emulsion shows signs of 'creaming', what does this indicate about the formulation's physical stability?

<p>The viscosity is too high. (D)</p> Signup and view all the answers

What ratio of oil, water, and emulsifier (gum) is traditionally employed when preparing an emulsion using the Dry Gum Method (Continental Method)?

<p>4:1:2 (D)</p> Signup and view all the answers

According to the Hydrophilic-Lipophilic Balance (HLB) system, which range of HLB values is generally MOST suitable for creating a water-in-oil (w/o) emulsion?

<p>1-3 (B)</p> Signup and view all the answers

During the compounding process, if it is necessary to combine methylcellulose with an API, what technique is MOST crucial for ensuring a homogenous suspension and preventing clumping?

<p>Heating the methylcellulose-API mixture to enhance solubility. (B)</p> Signup and view all the answers

Flashcards

Liquid Dosage Forms

Liquid form of a chemical compound used as a drug for administration.

Liquid Dosage Preparation

Dissolving drug in solvent, suspending drug, or incorporating the drug into oil or water.

Routes of Liquid Administration

Oral, topical, inhalation, and parenteral.

Dosage Form Objectives

Bioavailability, stability, compliance, and marketing.

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API

Active Pharmaceutical Ingredient.

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Reasons for Compounding

Change formulation, avoid excipient, commercially unavailable, add flavoring.

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Solutions

Clear homogenous preparations. Components don't separate. Active ingredients dissolved.

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Solution Advantages

Quicker absorption, versatile routes, easy adjustments, minimizes GI effects.

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Desired solution qualities

Efficacy, palatability, stability, appearance.

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Evaluate prescriptions?

Is it appropriate? Is the formulation reasonable?

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Compounding solutions?

Drug dissolve? Quantity? Dissolution time? Stay in solution? Stability? Preservative?

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Suspensions

Solid particles dispersed, not dissolved, in liquid phase.

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Reasons for suspensions?

Limited drug solubility, improved stability, easy administration, mask taste, dosing flexibility

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Suspension Ingredients

Wetting/levigating agent, suspending agent/vehicle, buffers, preservatives, flavoring, coloring.

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Emulsion

Liquid dispersed in another liquid, as tiny droplets.

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Emulsifying Agent

Surfactant – reduces surface tension between liquids.

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Emulsion Prep Methods

Dry gum, Wet Gum and Forbes Bottle method.

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Ideal Emulsion Qualities

Fine droplets, slow aggregation, easy redispersion.

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Undesirable emulsion?

Coalescence and Breaking

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Why use liquid dosage forms?

Medication route for patients who have a hard time swallowing solid dosage forms like pediatric patients, elderly, disease states, and oral surgery.

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Administration device

Materials & equipment to administer medication.

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Compounded drugs

A pharmacy may only dispense these drugs when a valid patient-specific prescription is available.

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Solute-solvent polarity

A solute will dissolve best in a solvent that has a similar polarity to itself.

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Water in solutions

Water is tasteless and lacks pharmacological activity used as a vehicle and a solvent.

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High Quality Ingredients

High quality ingredients used in this process are USP National Formulary (USP-NF), Food Chemicals Codex (FCC) substances list and Certificate of Analysis.

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Aqueous Solutions

Clear homogeneous preparations of water or aromatic water

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Non-Aqueous Solutions

Clear homogeneous preparations made from ethanol, glycerol, propylene glycol, certain oils

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Suspension types

Liquid preparations Oral, Topical and Injectable.

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Ideal Suspension Properties?

When making suspensions you want a fine particle size and uniform dispersion.

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Settling

This occurs when dispersed solid falls to the bottom of the container upon standing.

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Common Suspension Ingredients?

These are the API (active drug), wetting/levigating agent, suspending agent/vehicle, buffers/pH adjusting agents, preservatives flavoring and coloring.

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Stokes Law

Rate of solid descent in a liquid, factors include particle size, densities, and medium viscosity.

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Wetting/levigating agent

Is Added to disperse solids in a continuous liquid phase.

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Suspending agents

Acacia, Bentonite, Carbomer resins, Carboxymethylcellulose Sodium and Colloidal Silicon Dioxide.

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Creaming

Migration, due to difference in density, of the droplets of the internal phase to the top or bottom of the emulsion.

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Emulsion ingredients

These include API, Emulsifying agent (Surface active agent, Wetting agent), Internal phase, External phase and Additives.

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reasons for making an emulsion

This can improve taste, increase solubility and Increase stability.

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Methylcellulose

This synthetic substitute for natural gums is white, fibrous powder which swells in water to produce a clear, viscous colloidal solution

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Viscosity

Measurement to express a liquids resistance to flow or its thickness”, viscosity is determined with centipoise (cps) units.

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Compounding

Preparations made by a pharmacist to meet specific patient needs, altering strength, dosage, or combining drugs.

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Solutions (Pharmaceutical)

Liquid preparations with dissolved solutes in a solvent (typically water, alcohol, or glycerin).

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Syrups

Solutions containing a high sugar concentration, contributing to sweetness and viscosity.

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Elixirs

Clear, sweetened hydroalcoholic solutions, suitable for drugs with limited water solubility.

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Tinctures

Alcoholic or hydroalcoholic solutions from vegetable materials or chemical substances.

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Spirits (Pharmaceutical)

Alcoholic or hydroalcoholic solutions of volatile substances, used for flavoring or inhalation.

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Suspensions (Pharmaceutical)

Liquid preparations with insoluble solid particles dispersed in a liquid vehicle, requiring shaking before use.

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Emulsions (Pharmaceutical)

Mixtures of two immiscible liquids, stabilized by emulsifying agents.

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Purified Water

Pharmaceutical water purified to meet pharmacopeial standards, used as a solvent.

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Trituration

Reducing solid particle size via grinding with a mortar and pestle.

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Excipients

Ingredients besides the active drug, aiding absorption, stability, or manufacturing.

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Packaging

Protect dosage form integrity from instability or adverse effects.

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Settling in suspensions

Solid settles when a suspension stands.

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Agent for dispersion

Wetting/levigating Agent

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Flocculation

Globules form weak-bonded clusters, break easily when shaken.

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Methylcellulose Preparation

Measure amount; triturate; levigate with glycerin; geometric dilution; hydrate.

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Dry Gum Method

Continental Method, uses a 4:2:1 ratio.

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Internal Phase

The phase that becomes dispersed as droplets.

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External phase

The continuous liquid phase in which droplets are dispersed.

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Marketing (Dosage Forms)

Commercial considerations for dosage form design.

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Compliance (Dosage Forms)

Aids patient compliance with medication.

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Bioavailability

The rate and extent a drug becomes available at the site of action.

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Stability

Product must be reasonably stable for use.

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Liquid Dosage advantages

Reasons to use?

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HLB (emulsions)

Hydrophilic-Lipophilic Balance, is a range that indicates relative solubility.

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Dosage Form Marketing

Commercial considerations influence dosage form design, patent, trademark, etc.

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Excipients Role

Inactive ingredients supporting drug absorption or stability.

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Bioavailability goal

Drug must be bioavailable to exert its effect.

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Dosage stability

Product must be stable for use and shelf life.

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Dosage compliance

Product must be formulated for patient compliance.

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Liquid dosage forms, adminstration routes?

Oral, Topical, Inhalation and Parenteral

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API Source

Pure drug or modified versions like salts

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Commercial API

Capsules or extended release formulas.

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Solution Disadvantages

Bulky, difficulty transporting, storing and handling

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Water as Vehicle

Taste, lack of activity, used as a solvent

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Syrups vehicles

For water-soluble drugs, may be flavored

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Oils as vehicles

Corn, cottonseed, peanut oils for lipid soluble drugs

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Solution Types Include?

Syrups, Elixirs, Tinctures, Spirits

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MethylPrep first step?

Calculate amount; then measure; then triturate.

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Creaming Details

Density difference drives migration in emulsions.

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Desired stability?

Slows droplet aggregation and creaming.

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What is a Pharmaceutical Solution?

Any liquid in which one or more ingredients are completely and uniformly dissolved.

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What are Pharmaceutical Suspensions?

Liquid preparations consisting of solid particles dispersed throughout a liquid vehicle.

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What is a Pharmaceutical Emulsion?

A two-phase system where one liquid is dispersed as droplets within another immiscible liquid.

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What is a Solute?

The component of a solution present in a lesser amount and dissolves in the solvent.

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What is a Solvent?

The component of a solution present in a greater amount, in which the solute dissolves.

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What are Pharmaceutical Additives/Excipients?

Ingredients used in pharmaceutical formulations to enhance the stability, efficacy, or aesthetic appeal of the product.

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Parenteral Route

Dosage forms administered by injection, bypassing the digestive system.

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Why Favor Liquid Dosage Forms?

Reasons include pediatric use, difficulty swallowing, specific site targeting and flavoring.

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What Includes Clean Workspace and Hand Washing?

This involves compounding ingredients for a medication.

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What is Trituration?

Process of reducing a solid’s particle size by grinding it, typically with a mortar

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What is Geometric Dilution?

A method of mixing small amounts of a potent drug with a large amount of diluent to ensure even distribution.

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What is Viscosity?

The property of a liquid’s resistance to flow.

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What is a Thickening Agent?

A substance that increases the viscosity of a liquid.

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What is Sedimentation?

The process by which solid particles in a suspension settle over time.

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What are Pharmaceutical Preservatives?

Substances added to pharmaceutical preparations to preserve them from microbial growth.

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What are Wetting Agents?

Surfactants that promote wetting, allowing liquids to spread more easily on a solid surface.

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What is Levigation?

The process of combining a powder drug with a levigating agent to form a paste before incorporation into a suspension.

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What is a Levigating Agent?

Liquid used to aid reduction of particle size when grinding.

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What is Solubility?

Describes the degree to which a substance can dissolve in a solvent.

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What controls an O/W or W/O Emulsion?

The ratio of oil to water phases determines this emulsion type.

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What is a Surfactant?

Agent that lowers the surface tension between two liquids allowing them to mix.

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What is Coalescence of Emulsions?

The clumping together of droplets in an emulsion.

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What is Breaking of Emulsions?

Separation of an emulsion into distinct layers.

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What is an Oil-in-Water Emulsion?

An emulsion where oil is dispersed in water.

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What is a Water-in-Oil Emulsion?

An emulsion where water is dispersed in oil.

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What is the Hydrophilic-Lipophilic Balance (HLB)?

The ratio of hydrophilic to lipophilic portions of a surfactant.

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What is the Continental Method?

A method for preparing emulsions using oil, water and gum in a 4:2:1 ratio.

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What is Flavoring?

Reasons include to mask the taste of bitter drugs.

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Study Notes

  • No new information was provided, so the existing study notes remain unchanged.

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Description

Explore liquid dosage forms, where medications are administered as drugs. These forms offer advantages like ease of swallowing, making them suitable for elderly, pediatric, and surgery patients. Learn about their administration routes, stability, and the importance of bioavailability.

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