Liquid Dosage Forms: Solutions and Solubility
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Questions and Answers

Which component dissolves in the solvent to form a solution?

  • Solute (correct)
  • Isotonic agent
  • Excipient
  • Solvent

What is the main reason solutions are considered a suitable dosage form for geriatrics and pediatrics?

  • They have higher potency
  • They can easily be swallowed (correct)
  • They are easier to prepare
  • They have longer shelf life

What type of system/mixture consists of solute dissolved in a suitable solvent?

  • Hydrophobic system
  • Osmotic system
  • Homogenous system (correct)
  • Heterogeneous system

Which type of solutions may be applied topically to the skin or instilled to body cavities?

<p>Oily solutions (B)</p> Signup and view all the answers

In a solution, what is the component that dissolves the solute?

<p>Solvent (B)</p> Signup and view all the answers

What is the term for a solution that has uniformity of medicament throughout?

<p>Homogenous solution (B)</p> Signup and view all the answers

What is a disadvantage of solution dosage forms compared to solid dosage forms?

<p>Prone to microbial growth (C)</p> Signup and view all the answers

Which type of water is suitable for formulation of parenteral solutions?

<p>Water for injection (A)</p> Signup and view all the answers

Why is potable water freshly boiled and cooled immediately before use?

<p>To make it sterile (A)</p> Signup and view all the answers

Which type of compounds can water dissolve, making it a widely used solvent for pharmaceutical products?

<p>A wide range of compounds (C)</p> Signup and view all the answers

What is the main reason for using water for injection in the formulation of parenteral solutions?

<p>It is sterile and pyrogen-free (D)</p> Signup and view all the answers

Why are liquids considered a suitable dosage form for geriatrics and pediatrics?

<p>They can easily be adjusted according to the patient's need (B)</p> Signup and view all the answers

What is the primary disadvantage of liquid dosage forms in terms of chemical stability?

<p>They are more prone to chemical degradation (A)</p> Signup and view all the answers

Why are preservatives added to certain liquid solutions?

<p>To protect them from microbial attack (C)</p> Signup and view all the answers

Flashcards

Component dissolved in a solvent

The substance that dissolves in a solvent to form a solution.

Suitable dosage form for geriatrics/pediatrics: reason

Easy to swallow.

Solution system type

A homogenous mixture of a solute dissolved in a solvent.

Topical/cavity solutions

Solutions applied topically to the skin or instilled into body cavities.

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Solution's dissolving component

The component that dissolves the solute to form a solution.

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Homogenous solution

A solution with uniform medicament throughout

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Liquid dosage forms: disadvantage

More susceptible to microbial growth.

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Suitable water for parenteral solutions

Water for injection, sterile and pyrogen-free.

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Purifying potable water

Boiled and cooled freshly to make it sterile before use.

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Water's dissolving capacity

Water dissolves a wide range of compounds, making it a common solvent in pharmaceuticals.

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Reason for Water for Injection

Sterile and pyrogen-free, vital for parenteral solutions.

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Liquid dosage forms: advantage for patients

Easily adjustable to individual needs.

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Chemical instability of liquids

Liquid dosage forms more prone to chemical degradation than solids.

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Preservatives in liquid solutions

Added to prevent microbial attack.

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Study Notes

Solutions and Dosage Forms

  • Solute dissolves in the solvent to form a solution.
  • Solutions are suitable for geriatrics and pediatrics due to easy administration and precise dosing.
  • A system with solute dissolved in a suitable solvent is referred to as a solution or mixture.
  • Topical applications for skin or body cavities typically involve aqueous or non-aqueous solutions.
  • The solvent is the component that dissolves the solute in a solution.
  • A solution with uniform distribution of the medicament is called a homogeneous solution.

Disadvantages and Considerations

  • A disadvantage of solution dosage forms compared to solid forms is generally lower stability and potential for a shorter shelf-life.
  • Sterile water for injection is suitable for formulating parenteral solutions.
  • Potable water is freshly boiled and cooled before use to eliminate microbial contamination.
  • Water can dissolve ionic and polar compounds, making it an effective solvent in pharmaceuticals.
  • Water for injection is primarily used due to its sterility and lack of additives, ensuring safety in parenteral formulations.

Special Populations and Stability

  • Liquids provide a suitable dosage form for geriatrics and pediatrics because they are easier to swallow and adjust in dosage.
  • The primary disadvantage of liquid dosage forms is their chemical instability, which can lead to degradation or reduced effectiveness.
  • Preservatives are added to certain liquid solutions to prevent microbial growth and extend shelf-life.

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Test your knowledge of liquid dosage forms, with a focus on solutions and solubility. Explore the definition, types, advantages, and disadvantages of solutions, as well as the factors affecting solubility and methods of increasing solubility.

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