10 Questions
What is liquefactive necrosis and in what situations is it commonly seen?
Liquefactive necrosis is a type of necrosis where dead cells are completely digested, resulting in transformation of the affected tissue into a liquid viscous mass enclosed within a cystic cavity. It is commonly seen in situations of focal bacterial infection (or occasionally fungal infections) and ischemic destruction of brain tissue.
What is the process that leads to liquefactive necrosis in cases of bacterial infection?
In cases of bacterial infection, microbes stimulate the accumulation of inflammatory cells and the enzymes of the leukocytes digest (liquefy) the tissue, leading to liquefactive necrosis.
What is the term used to describe a limb, generally the lower leg, that has lost its blood supply?
Gangrenous necrosis is the term used to describe a limb, generally the lower leg, that has lost its blood supply.
Is gangrenous necrosis a distinctive pattern of cell death?
No, gangrenous necrosis is not a distinctive pattern of cell death, but the term is still commonly used in clinical practice.
What is the appearance of liquefied material in cases of pyogenic bacterial infection?
In cases of pyogenic bacterial infection, the liquefied material is frequently creamy yellow and is called pus.
What are the morphological characteristics of coagulative necrosis?
Preservation of cell outlines, homogenous eosinophilic appearance, loss of cytoplasmic RNA and glycogen, and presence of pyknosis, karyorrhexis, or karyolysis in the nucleus.
Which type of necrosis is most commonly observed?
Coagulative necrosis.
What is the typical appearance of caseous necrosis?
Amorphous, granular eosinophilic material surrounded by a rim of inflammatory cells.
Which type of necrosis is characterized by the hydrolytic action of lipases on fat?
Enzymatic fat necrosis.
What happens to fatty acids released via hydrolysis in enzymatic fat necrosis?
They react with Ca++ to form chalky white areas called 'saponification'.
Test your knowledge on Liquefactive Necrosis and its association with bacterial and fungal infections. Learn about the transformation of affected tissues into a liquid viscous mass and the role of inflammatory cells.
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