Lipopeptides and Daptomycin Quiz
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Questions and Answers

Which type of infections are lipopeptides like daptomycin indicated for?

  • Complicated skin and skin structure infections (correct)
  • Complicated urinary tract infections
  • Complicated respiratory tract infections
  • Complicated gastrointestinal infections

    • What is the spectrum of activity of lipopeptides like daptomycin?

  • Active only against Gram-negative bacteria
  • Active only against Gram-positive bacteria (correct)
  • Active against both Gram-positive and Gram-negative bacteria
  • Active against both Gram-positive and Gram-negative bacteria, including drug-resistant strains

    • What is the mechanism of action of lipopeptides like daptomycin?

  • Inhibiting DNA replication
  • Inhibiting protein synthesis
  • Disrupting cell wall synthesis
  • Disrupting plasma membrane function without penetrating into the cytoplasm (correct)

    • How does the acyl tail portion of lipopeptides like daptomycin act?

    <p>It binds and inserts itself into the cytoplasmic membrane</p> Signup and view all the answers

    What happens when the acyl tail portion of lipopeptides like daptomycin inserts itself into the cytoplasmic membrane?

    <p>It forms a channel that causes depolarization of the membrane</p> Signup and view all the answers

    What is the route of administration for lipopeptides like daptomycin?

    <p>Intravenous (IV)</p> Signup and view all the answers

    How often is lipopeptide daptomycin administered intravenously?

    <p>Once daily</p> Signup and view all the answers

    Which type of bacteria are lipopeptides like daptomycin active against?

    <p>Gram-positive bacteria</p> Signup and view all the answers

    What is the mechanism of action of lipopeptides like daptomycin?

    <p>Disrupt plasma membrane function without penetrating into the cytoplasm</p> Signup and view all the answers

    What is the spectrum of activity of lipopeptides like daptomycin?

    <p>Active against Gram-positive bacteria only</p> Signup and view all the answers

    Which bacteria are resistant to lipopeptides like daptomycin?

    <p>Vancomycin-resistant E. faecium</p> Signup and view all the answers

    What are the adverse effects of lipopeptides like daptomycin?

    <p>Nephrotoxicity and neurotoxicity</p> Signup and view all the answers

    Which adverse effects are associated with systemic administration of lipopeptides like daptomycin?

    <p>Liver and kidney toxicity</p> Signup and view all the answers

    What is the mechanism of action of lipopeptides like daptomycin?

    <p>They interact strongly with phospholipids and disrupt the structure of cell membranes</p> Signup and view all the answers

    Which type of bacteria are lipopeptides like daptomycin most active against?

    <p>Gram-positive bacteria</p> Signup and view all the answers

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