Lipopeptides and Daptomycin Quiz

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Questions and Answers

Which type of infections are lipopeptides like daptomycin indicated for?

  • Complicated skin and skin structure infections (correct)
  • Complicated urinary tract infections
  • Complicated respiratory tract infections
  • Complicated gastrointestinal infections

What is the spectrum of activity of lipopeptides like daptomycin?

  • Active only against Gram-negative bacteria
  • Active only against Gram-positive bacteria (correct)
  • Active against both Gram-positive and Gram-negative bacteria
  • Active against both Gram-positive and Gram-negative bacteria, including drug-resistant strains

What is the mechanism of action of lipopeptides like daptomycin?

  • Inhibiting DNA replication
  • Inhibiting protein synthesis
  • Disrupting cell wall synthesis
  • Disrupting plasma membrane function without penetrating into the cytoplasm (correct)

How does the acyl tail portion of lipopeptides like daptomycin act?

<p>It binds and inserts itself into the cytoplasmic membrane (D)</p> Signup and view all the answers

What happens when the acyl tail portion of lipopeptides like daptomycin inserts itself into the cytoplasmic membrane?

<p>It forms a channel that causes depolarization of the membrane (A)</p> Signup and view all the answers

What is the route of administration for lipopeptides like daptomycin?

<p>Intravenous (IV) (B)</p> Signup and view all the answers

How often is lipopeptide daptomycin administered intravenously?

<p>Once daily (D)</p> Signup and view all the answers

Which type of bacteria are lipopeptides like daptomycin active against?

<p>Gram-positive bacteria (B)</p> Signup and view all the answers

What is the mechanism of action of lipopeptides like daptomycin?

<p>Disrupt plasma membrane function without penetrating into the cytoplasm (A)</p> Signup and view all the answers

What is the spectrum of activity of lipopeptides like daptomycin?

<p>Active against Gram-positive bacteria only (A)</p> Signup and view all the answers

Which bacteria are resistant to lipopeptides like daptomycin?

<p>Vancomycin-resistant E. faecium (D)</p> Signup and view all the answers

What are the adverse effects of lipopeptides like daptomycin?

<p>Nephrotoxicity and neurotoxicity (A)</p> Signup and view all the answers

Which adverse effects are associated with systemic administration of lipopeptides like daptomycin?

<p>Liver and kidney toxicity (A)</p> Signup and view all the answers

What is the mechanism of action of lipopeptides like daptomycin?

<p>They interact strongly with phospholipids and disrupt the structure of cell membranes (A)</p> Signup and view all the answers

Which type of bacteria are lipopeptides like daptomycin most active against?

<p>Gram-positive bacteria (B)</p> Signup and view all the answers

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