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Lipid Synthesis Pathways Overview

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Questions and Answers

What is the precursor for both triacylglycerol and phospholipids?

CoA

Dihydroxyacetone phosphate

Phosphatidate (correct)

Glycerol-3-P

Which complex is used in the ER lumen for the synthesis of triacylglycerol from Phosphatidate?

Phospholipase complex

Triacylglycerol synthetase complex (correct)

Glycolysis complex

Acetyl-CoA complex

How is CDP-diacylglycerol synthesized in yeast and bacteria?

By linking dihydroxyacetone phosphate

By linking glycerol-3-P

By linking CTP molecules (correct)

By linking CoA

What drives the reaction forward during the formation of CDP-diacylglycerol?

Release of pyrophosphate Signup and view all the answers

Which molecule links with CDP to activate diacylglycerol in mammals?

Ethanolamine Signup and view all the answers

What is the most abundant phospholipid in animals?

Phosphatidylcholine Signup and view all the answers

What is the precursor for cholesterol synthesis?

Acetyl CoA Signup and view all the answers

Which enzyme is responsible for synthesizing phosphatidylcholine from phosphatidylethanolamine?

Phosphatidylethanolamine methyltransferase Signup and view all the answers

What is the main factor regulating cholesterol synthesis?

Cholesterol levels Signup and view all the answers

Which molecule is used as the methyl donor in methylating the amino group of phosphatidylcholine?

S-adenosylmethionine Signup and view all the answers

Where does the last step of cholesterol synthesis occur?

Endoplasmic reticulum (ER) Signup and view all the answers

Which enzyme catalyzes the conversion of mevalonate to isoprene molecules in cholesterol synthesis?

HMG-CoA reductase Signup and view all the answers