Lipid Metabolism: Module 4.2

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Questions and Answers

Excess energy from carbohydrates and proteins is stored in ______ molecules, which are later mobilized and used as needed.

lipid

The primary change that triacylglycerols (TAGs) undergo in the mouth is ______, as chewing breaks down food into smaller particles.

physical

The release of bile from the gallbladder is triggered by ______, leading to the emulsification of TAGs into smaller particles.

chyme

[Blank] help in the formation of micelles, tiny spherical droplets that enhance the absorption of fatty acids and monoacylglycerols through intestinal cell membranes.

<p>bile</p> Signup and view all the answers

Inside intestinal cells, fatty acid and monoacylglycerol components are reassembled into ______, which combine with membrane lipids and proteins to form chylomicrons.

<p>TAGs</p> Signup and view all the answers

[Blank] transport triacylglycerols (TAGs) from intestinal cells to the bloodstream through the lymphatic system.

<p>chylomicrons</p> Signup and view all the answers

In the bloodstream, lipoprotein lipases hydrolyze triacylglycerols (TAGs) carried by chylomicrons into ______ and free fatty acids.

<p>glycerol</p> Signup and view all the answers

[Blank] are specialized cells found in adipose tissue that are responsible for the storage of triacylglycerols (TAGs).

<p>adipocytes</p> Signup and view all the answers

Hormones like epinephrine and ______ trigger the mobilization of triacylglycerols (TAGs) stored in adipose tissue for energy production.

<p>glucagon</p> Signup and view all the answers

Hormone-sensitive lipase (HSL) is activated via ______, which is necessary for the hydrolysis of triacylglycerols (TAGs) into fatty acids and glycerol.

<p>phosphorylation</p> Signup and view all the answers

During triacylglycerol mobilization, one molecule of ______ is produced for each triacylglycerol completely hydrolyzed.

<p>glycerol</p> Signup and view all the answers

Before fatty acids can be oxidized, they must be activated by bonding to ______.

<p>coenzyme A</p> Signup and view all the answers

The activated fatty acid molecule, acyl CoA, cannot directly pass through the mitochondrial membrane and requires ______ for transport into the mitochondrial matrix.

<p>carnitine</p> Signup and view all the answers

The process by which fatty acids are degraded, that involves the repetitive removal of two-carbon units from an acyl CoA molecule is called ______.

<p>β-oxidation pathway</p> Signup and view all the answers

In each cycle of the β-oxidation pathway, the fatty acid carbon chain is broken between the alpha and beta carbons by reaction with a coenzyme A molecule in a process called ______.

<p>thiolysis</p> Signup and view all the answers

The presence of two additional enzymes is required to allow the oxidation of unsaturated acids by the β-oxidation pathway; one is that they are cis double bonds rather than trans, therefore they need a ______ that transforms D configuration acids to L configuration acids.

<p>epimerase</p> Signup and view all the answers

In the fatty acid oxidation and glucose oxidation comparison, the amount of ATP, it is shown a C18 stearic acid molecule produced ______ times as much ATP as a glucose molecule.

<p>4</p> Signup and view all the answers

The metabolic pathway by which ketone bodies are synthesized from acetyl CoA is known as ______.

<p>ketogenesis</p> Signup and view all the answers

In fatty acid synthesis, fatty acids are built up two carbons at a time during synthesis and are broken down two carbons at a time during degradation, in this process a ______ derivative is involved.

<p>CoA</p> Signup and view all the answers

[Blank] may undergo further processing via the citric acid cycle (CAC), the electron transport chain (ETC), and oxidative phosphorylation in order to produce adenosine triphosphate (ATP) for cellular demands.

<p>acetyl-CoA</p> Signup and view all the answers

Flashcards

Lipids

Energy-rich molecules stored in adipose tissue; used as fuel for cellular metabolism.

Triacylglycerols (TAGs)

The main type of dietary lipid, composed of glycerol and three fatty acids.

Initial Digestion in the Mouth

Physical breakdown via chewing aids in reducing food size; no chemical change involved.

Digestion in the Stomach

Churning further breaks down TAGs; gastric lipase initiates their hydrolysis.

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Digestion in the Small Intestine

The gallbladder releases bile to emulsify TAGs; pancreatic lipases hydrolyze TAGs into fatty acids and monoacylglycerols.

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Micelles

Tiny spherical droplets formed with the help of bile that enhance absorption of fatty acids and monoacylglycerols.

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Hydrolysis in the Bloodstream

Process where lipoprotein lipases hydrolyze TAGs into glycerol and free fatty acids for energy.

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Adipocytes

Specialized cells in adipose tissue that store TAGs.

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Mobilization of TAGs

Hormones trigger the mobilization of TAGs into fatty acids and glycerol for energy use.

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Hormone-Sensitive Lipase (HSL)

Enzyme activated by cAMP, necessary for the hydrolysis of TAGs.

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TAG Energy Reserves

TAGs are the body's major energy reserve, far exceeding reserves from protein, glycogen, and glucose.

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Glycerol Metabolism

Conversion of glycerol to dihydroxyacetone phosphate, an intermediate in glycolysis and gluconeogenesis.

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Oxidation of Fatty Acids

Process by which fatty acids are broken down to obtain energy.

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Fatty Acid Activation

Fatty acid bonding to coenzyme A for activation; transported into mitochondria.

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β-Oxidation Pathway

Pathway where fatty acids degrade to acetyl CoA, producing FADH2 and NADH.

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Ketone Bodies

Condition where excess acetyl CoA forms ketone bodies due to imbalances.

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Ketogenesis

Metabolic pathway synthesizing ketone bodies from acetyl CoA, primarily in liver mitochondria.

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Lipogenesis

Metabolic pathway for fatty acid synthesis from acetyl CoA, occurring in the cell cytosol.

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Citrate-Malate Shuttle

A system involving citrate ions to transport acetyl CoA from the mitochondria to the cytosol.

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Unsaturated Fatty Acid Biosynthesis

Requires molecular oxygen; introduces double bonds; produces essential fatty acids.

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