Lipid Metabolism Chapter 21 Quiz
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Questions and Answers

What is the main advantage of the β-oxidation of fats compared to the oxidation of sugars?

  • For every cycle of oxidation of a fatty acid, one NADH and one FADH2 are produced
  • Fatty acids produce more metabolic water (correct)
  • The oxidation of fats produces more energy per carbon than the oxidation of carbohydrates
  • Fat yields more energy than carbohydrates because it is more oxidized

    • What additional enzymes are required for the β-oxidation of fatty acids with an odd number of carbons?

  • A dehydrogenase and a reductase
  • A dehydrogenase and a hydrase
  • A cis-trans isomerase and a dehydrogenase (correct)
  • A cis-trans isomerase and a reductase

    • What cofactor is involved in the conversion of methylmalonyl-CoA to succinyl-CoA?

  • Thiamine pyrophosphate
  • Biotin
  • Vitamin B12 (correct)
  • NAD

    • How do the cis double bonds of naturally-occurring fatty acids react with the hydratase enzyme?

    <p>The cis double bonds do not react well with the hydratase enzyme</p> Signup and view all the answers

    What is the orientation of the unsaturated fatty acids that are intermediates in the β-oxidation cycle?

    <p>The trans orientation</p> Signup and view all the answers

    How does the yield of ATP from the oxidation of an unsaturated fatty acid compare to the yield from the oxidation of a saturated fatty acid with the same number of carbon atoms?

    <p>Less</p> Signup and view all the answers

    What are the products of β-oxidation of oleic acid (18:1Δ9)?

    <p>Acetyl-CoA, propionyl-CoA, and succinyl-CoA</p> Signup and view all the answers

    How many ATP equivalents are required for the activation of oleic acid (18:1Δ9) prior to β-oxidation?

    <p>4 ATP</p> Signup and view all the answers

    What is the ultimate fate of the propionyl-CoA produced during β-oxidation of odd-chain fatty acids?

    <p>It is converted to succinyl-CoA and enters the TCA cycle</p> Signup and view all the answers

    Which of the following is NOT a possible use of the acetyl-CoA produced during β-oxidation?

    <p>Synthesis of glucose</p> Signup and view all the answers

    How many NAD+ are reduced during the β-oxidation of stearoyl-CoA (18:0) to form nine molecules of acetyl-CoA?

    <p>16</p> Signup and view all the answers

    What is the correct sequence for the transport of fatty acyl groups from the cytosol to the mitochondrial matrix?

    <p>Activation to acyl-CoA, carnitine shuttle, β-oxidation</p> Signup and view all the answers

    Which of the following is a product of the complete β-oxidation of oleic acid (C18:1)?

    <p>8 acetyl-CoA and 1 propionyl-CoA</p> Signup and view all the answers

    How is propionyl-CoA converted to a metabolite that can enter the TCA cycle?

    <p>It is carboxylated to form succinyl-CoA, which then enters the TCA cycle.</p> Signup and view all the answers

    Which of the following is a major fate of acetyl-CoA produced from β-oxidation?

    <p>All of the above</p> Signup and view all the answers

    Which of the following statements about β-oxidation of fatty acids is true?

    <p>It involves the hydration of a double bond as the first step.</p> Signup and view all the answers

    How many $FADH_2$ and $NADH$ molecules are produced during the complete β-oxidation of palmitic acid (C16:0)?

    <p>7 $FADH_2$, 8 $NADH$</p> Signup and view all the answers

    Which of the following statements about the energetics of β-oxidation is false?

    <p>The first step of β-oxidation, catalyzed by acyl-CoA dehydrogenase, is an energy-requiring reaction.</p> Signup and view all the answers

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