18 Questions
What is the main advantage of the β-oxidation of fats compared to the oxidation of sugars?
Fatty acids produce more metabolic water
What additional enzymes are required for the β-oxidation of fatty acids with an odd number of carbons?
A cis-trans isomerase and a dehydrogenase
What cofactor is involved in the conversion of methylmalonyl-CoA to succinyl-CoA?
Vitamin B12
How do the cis double bonds of naturally-occurring fatty acids react with the hydratase enzyme?
The cis double bonds do not react well with the hydratase enzyme
What is the orientation of the unsaturated fatty acids that are intermediates in the β-oxidation cycle?
The trans orientation
How does the yield of ATP from the oxidation of an unsaturated fatty acid compare to the yield from the oxidation of a saturated fatty acid with the same number of carbon atoms?
Less
What are the products of β-oxidation of oleic acid (18:1Δ9)?
Acetyl-CoA, propionyl-CoA, and succinyl-CoA
How many ATP equivalents are required for the activation of oleic acid (18:1Δ9) prior to β-oxidation?
4 ATP
What is the ultimate fate of the propionyl-CoA produced during β-oxidation of odd-chain fatty acids?
It is converted to succinyl-CoA and enters the TCA cycle
Which of the following is NOT a possible use of the acetyl-CoA produced during β-oxidation?
Synthesis of glucose
How many NAD+ are reduced during the β-oxidation of stearoyl-CoA (18:0) to form nine molecules of acetyl-CoA?
16
What is the correct sequence for the transport of fatty acyl groups from the cytosol to the mitochondrial matrix?
Activation to acyl-CoA, carnitine shuttle, β-oxidation
Which of the following is a product of the complete β-oxidation of oleic acid (C18:1)?
8 acetyl-CoA and 1 propionyl-CoA
How is propionyl-CoA converted to a metabolite that can enter the TCA cycle?
It is carboxylated to form succinyl-CoA, which then enters the TCA cycle.
Which of the following is a major fate of acetyl-CoA produced from β-oxidation?
All of the above
Which of the following statements about β-oxidation of fatty acids is true?
It involves the hydration of a double bond as the first step.
How many $FADH_2$ and $NADH$ molecules are produced during the complete β-oxidation of palmitic acid (C16:0)?
7 $FADH_2$, 8 $NADH$
Which of the following statements about the energetics of β-oxidation is false?
The first step of β-oxidation, catalyzed by acyl-CoA dehydrogenase, is an energy-requiring reaction.
Test your knowledge on lipid metabolism with this quiz focusing on the advantages of β-oxidation of fats compared to oxidation of sugars, energy production, and the oxidation of unsaturated fatty acids.
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