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Questions and Answers
What is the primary function of apoC-II in chylomicrons?
What is the primary function of apoC-II in chylomicrons?
- To inhibit the release of free fatty acids
- To activate lipoprotein lipase in capillaries (correct)
- To synthesize triacylglycerols in the ER
- To target lipoproteins to the liver
Where are chylomicrons synthesized?
Where are chylomicrons synthesized?
- In adipose tissue
- In the ER of epithelial cells lining the small intestine (correct)
- In the lymphatic system
- In the liver
What is the main lipid component of chylomicrons?
What is the main lipid component of chylomicrons?
- Phospholipids
- Triacylglycerols (correct)
- Cholesterol
- Glycolipids
Where do chylomicron remnants ultimately end up?
Where do chylomicron remnants ultimately end up?
What is unique to chylomicrons among lipoproteins?
What is unique to chylomicrons among lipoproteins?
What is the primary destination of dietary triacylglycerols carried by chylomicrons?
What is the primary destination of dietary triacylglycerols carried by chylomicrons?
How do chylomicrons enter the bloodstream?
How do chylomicrons enter the bloodstream?
What is the function of apolipoproteins in lipoproteins?
What is the function of apolipoproteins in lipoproteins?
What is the characteristic of chylomicrons that makes them the largest of the lipoproteins?
What is the characteristic of chylomicrons that makes them the largest of the lipoproteins?
What is the fate of chylomicron remnants after they reach the liver?
What is the fate of chylomicron remnants after they reach the liver?
What is the role of lipoprotein lipase in chylomicron metabolism?
What is the role of lipoprotein lipase in chylomicron metabolism?
Flashcards
Lipoprotein function
Lipoprotein function
Lipoproteins transport lipids in the bloodstream, including cholesterol and triglycerides.
Chylomicron role
Chylomicron role
Chylomicrons transport dietary fats, mostly triglycerides, from the intestines to other parts of the body.
VLDL function
VLDL function
VLDL carries triglycerides from the liver to the tissues.
IDL function
IDL function
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LDL function
LDL function
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HDL function
HDL function
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Ketone body formation
Ketone body formation
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Lipid digestion
Lipid digestion
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Bile salts role
Bile salts role
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Cholesterol & Transport
Cholesterol & Transport
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Study Notes
Lipoproteins
- Lipoproteins transport lipids in the bloodstream; major classes include chylomicrons, VLDL, IDL, LDL, and HDL.
- Chylomicrons are formed in the intestine, primarily transport triacylglycerols, and contain apolipoproteins A-I, A-II, A-IV, B-48, C-I, C-II, C-III, and E.
- Chylomicron remnants, produced after lipolysis, are rich in cholesterol and apolipoproteins B-48 and E, and are transported to the liver.
- VLDL is synthesized in the liver and intestine, primarily carries triacylglycerols, and contains apolipoproteins B-100, C-I, C-II, and C-III.
- As VLDL is metabolized, it transforms into IDL, which contains both triacylglycerols and cholesterol and has apolipoproteins B-100 and E.
- LDL is derived from VLDL and is primarily composed of cholesterol, with apolipoprotein B-100; high levels are linked to cardiovascular diseases.
- HDL, produced in the liver and intestine, transports phospholipids and cholesterol and contains multiple apolipoproteins, promoting cholesterol efflux from tissues.
Ketone Bodies
- Ketone bodies (acetoacetate, β-hydroxybutyrate, and acetone) are produced in the liver during prolonged fat metabolism to freely supply CoA for β-oxidation.
- Their formation enhances fat metabolism by preventing CoA depletion and enabling acetyl-CoA utilization.
- Increased fat oxidation occurs during fasting, prompting liver enzyme induction for ketogenesis, while brain cells upregulate metabolism of ketone bodies.
Lipid Digestion and Absorption
- Major dietary lipids include triacylglycerols and phospholipids, requiring hydrolysis and emulsification into micelles for absorption.
- Fat-soluble vitamins (A, D, E, K) and various lipids like cholesterol are absorbed within lipid micelles.
- Bile salts, secreted from the liver, facilitate lipid emulsification and micelle formation, aiding lipid digestion and absorption in the intestines.
Impact of Cholesterol
- Cholesterol, being insoluble in blood, binds to lipoproteins HDL and LDL for transport; high blood cholesterol levels are associated with arterial plaque, heart disease, and stroke.
- Specific apolipoproteins in lipoproteins play essential roles in targeting, metabolism, and activation of enzymes that act on lipoproteins.
- Chylomicrons transport dietary triacylglycerols from the intestine to peripheral tissues, where they are utilized or stored as energy.
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