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Questions and Answers
What is the primary purpose of linkage analysis?
What is the primary purpose of linkage analysis?
- To detect loci with small effect size
- To detect co-segregation of alleles with a marker locus in family data (correct)
- To identify common alleles in the population
- To study the variation of a quantitative trait
Why are linkage studies powerful in detecting loci with large effect size?
Why are linkage studies powerful in detecting loci with large effect size?
- They are effective in identifying rare variants
- They focus on common alleles in the population
- They have high power to detect alleles with a large effect size (correct)
- They are designed to detect loci with small effect size
What is a limitation of association studies compared to linkage studies?
What is a limitation of association studies compared to linkage studies?
- They are not designed for quantitative traits
- They have low power to detect rare variants with large effect size (correct)
- They focus on family data
- They are ineffective in identifying common alleles
What type of variants do genome-wide association studies focus on?
What type of variants do genome-wide association studies focus on?
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In what cases were linkage studies successful in detecting regions of the genome?
In what cases were linkage studies successful in detecting regions of the genome?
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