Linkage Analysis in Next-Generation Sequencing

To detect loci with small effect size

To detect co-segregation of alleles with a marker locus in family data (correct)

To identify common alleles in the population

To study the variation of a quantitative trait

They are effective in identifying rare variants

They focus on common alleles in the population

They have high power to detect alleles with a large effect size (correct)

They are designed to detect loci with small effect size

They are not designed for quantitative traits

They have low power to detect rare variants with large effect size (correct)

They focus on family data

They are ineffective in identifying common alleles

<p>Common alleles with small effect size</p> Signup and view all the answers

<p>Likely to harbor rare variants with large effect for simple Mendelian diseases and complex traits</p> Signup and view all the answers